Complete Regression of Melanocytic Nevi: Correlation Between Clinical, Dermoscopic, and Histopathologic Findings in 13 Patients

Martín, J.M.; Rubio, Miguel López; Bella, Rebeca; Jordá, Esperanza; Monteagudo, Carlos

doi:10.1016/j.adengl.2012.06.017

Cited by 9 publications

(14 citation statements)

References 42 publications

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“…As far as we know, in the only previous histological study about fading nevi, delicate fibrosis with subepidermal location was observed in 61.5% of the cases. 8 We also noticed that vessel increase was statistically more frequent in cases than in controls. This result would agree with the global SIAScopic study since the presence of vascular structures was the most frequent regression feature found in our series.…”

Section: Discussionmentioning

confidence: 50%

“…But, in the last years, depigmentation of melanocytic nevi and melanoma without the halo phenomenon was documented and shading or fading nevi have been described mainly in patients with atypical naevus syndrome digitally followed. [7][8][9] Different ways of naevus involution according to dermoscopic changes have been proposed. 1 The first pattern is the halo phenomenon, an immune-mediated process primarily involving Tcell lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][9][10][11][12] From the first case published in 1960, literature about serial photographic or dermoscopic pictures of fading melanocytic nevi is very sparse 9,[13][14][15][16][17] and histopathological studies are still scarcer. 8 The aim of our study was to describe the frequency and morphology of naevus involution in a series of patients with atypical naevus syndrome under digital follow-up with a SIAscopy program and, in a small sample of fading-type involutive nevi, to analyse histological features and immunohistochemical biomarkers in order to increase our knowledge about this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

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Descriptive study of naevus involution in a series of 74 patients with atypical naevus syndrome under SIAscopy digital follow‐up

Moreno

Maiques

Gatius

et al. 2020

Acad Dermatol Venereol

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Background Characterization of nevi involution could help to understand the biological behaviour of melanocytic neoplasms. Objective To describe the frequency and morphology of naevus involution in a series of patients with atypical naevus syndrome under digital follow-up with a SIAscopy program and, in a small sample of fading nevi, to analyse histopathological features and immunohistochemical biomarkers. Methods Seventy-four patients registered from April 2007 to July 2014 in the SIAscopy system of the Department of Dermatology of Hospital Arnau de Vilanova of Lleida, Spain, were reviewed. Fourteen naevus cases with fading features were prospectively excised during follow-up. Eleven already excised naevus controls were randomly selected from our archive. Results We observed that 81% of patients showed, at least, one involutive naevus and 25% of recorded nevi presented this phenomenon; the mean time of involution was 46.7 months. The predominant structural pattern was reticular (>70%), and the most frequently observed regression structures were vascular (33.8%). Histopathological significant higher intensity of inflammatory infiltrate in controls and higher presence of laminar and compact fibrosis and increase of vessels in cases were demonstrated. Regarding immunohistochemical biomarkers, only higher expression of cytoplasmic activated caspase 3 in controls was significant. Conclusions Naevus involution is a common phenomenon in patients with dysplastic naevus syndrome. It is usually a slow process, more frequent in naevus with reticular pattern. SIAscopy regression structures are uncommon, with the exception of vascular ones. Histologically, fading involutive pattern is characterized by scarce inflammatory infiltrate and melanophages, delicate fibrosis and increase of vessels.

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Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Descriptive study of naevus involution in a series of 74 patients with atypical naevus syndrome under SIAscopy digital follow‐up

Moreno

Maiques

Gatius

et al. 2020

Acad Dermatol Venereol

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“…Nevus is an unusual benign mole with distinct boundary that may resemble melanoma [30]. In the OCT angiogram, the vascular pattern of nevus was identified having irregular linear vessels that barely branch, which gives a favorable agreement to a result by classical dermascopy [31]. …”

Section: Resultsmentioning

confidence: 99%

Potential use of OCT‐based microangiography in clinical dermatology

Baran

Choi

Wang

2015

Skin Research and Technology

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Background and Objective Optical coherence tomography (OCT) is a revolutionary imaging technique used commonly in ophthalmology, and on the way to become clinically viable alternative in dermatology due to its capability of acquiring histopathology level details of in vivo tissue, noninvasively. In this study, we demonstrate the capabilities of OCT-based microangiography in detecting high-resolution, three-dimensional structural and microvascular features of in vivo human skin with various conditions. Materials and Methods A swept source OCT system that operates on a central wavelength of 1310 nm with an A-line rate of 100 kHz is used in this study. We apply optical microangiography (OMAG) technique to visualize the structural and microvascular changes in tissue. Results OMAG images provide detailed visualization of functional microvasculature of healthy human skin from cheek and forehead areas, abnormal skin conditions from face, chest and belly. Moreover, OMAG is capable of monitoring the progress of wound healing on human skin from arm, delivering unprecedented detail of microstructural and microvascular information during longitudinal wound healing process. Conclusion The presented results promise the clinical use of OCT angiography, aiming to treat prevalent cutaneous diseases, by detecting blood perfusion, and structural changes within human skin, in vivo.

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“…There are rare reports of completely regressed melanoma admixed with melanocytic naevus that shows no features of regression 36. The histophenotypical features of regressed naevus and melanoma may be different, suggesting separate molecular mechanisms.…”

Section: Differential Diagnosismentioning

confidence: 99%

Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach

et al. 2015

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The differential diagnosis of heavily pigmented melanocytic neoplasms includes melanoma (especially animal type), melanosis of partially or completely regressed melanoma, blue naevus (BN), pigmented Spitzoid lesions, recurrent naevus, combined naevus, pigmented spindle cell naevus, epithelioid blue naevus of the Carney complex/pigmented epithelioid melanocytoma, deep penetrating naevus, hyperpigmented scar after surgery of melanoma in which there are also melanophages and hyperpigmentation due to the minocycline, a tattoo or a hyperpigmented scar. Pathologists face challenges when evaluating a pigmented lesion, especially in a small superficial biopsy, because it is difficult to access important histopathological features to differentiate benign versus malignant melanocytic lesions. The histological features that favour a diagnosis of melanoma include dimension (>6 mm), asymmetry, poor circumscription, irregular confluent nests, confluent lentiginous junctional melanocytic proliferation, lack of maturation with descent in the dermis, suprabasal pagetoid melanocytes, asymmetrical distribution of melanin pigment, cytological atypia, dermal mitotic figures, asymmetrical dermal lymphocytic infiltrate and necrosis.

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Complete Regression of Melanocytic Nevi: Correlation Between Clinical, Dermoscopic, and Histopathologic Findings in 13 Patients

Cited by 9 publications

References 42 publications

Descriptive study of naevus involution in a series of 74 patients with atypical naevus syndrome under SIAscopy digital follow‐up

Descriptive study of naevus involution in a series of 74 patients with atypical naevus syndrome under SIAscopy digital follow‐up

Potential use of OCT‐based microangiography in clinical dermatology

Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach

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