Complete Regression of Primary Cardiac Lymphoma With Dose-Attenuated R-CVP Chemotherapeutic Regimen

Mandal, Amit K J; Selby, Faye L.; Deoraj, Stuart; Metaxa, Sofia; Missouris, Constantinos G

doi:10.1016/j.jaccas.2019.06.033

Cited by 2 publications

(2 citation statements)

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“…Anthracyclines are cardiotoxic and may lead to left ventricular dysfunction or heart failure ( 19 ). Mandal et al believed that drug-related cardiotoxicity may be reduced by omitting the anthracycline agent, doxorubicin ( 20 ). The first cycle of chemotherapy should be administered with caution because of the high risk of cardiac rupture during rapid tumor regression ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Complete atrio-ventricular block successfully reversed in newly diagnosed primary cardiac B-cell lymphoma

Mao

Xu²,

Zhu³

et al. 2023

Front. Med.

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Primary cardiac tumors are extremely uncommon and primary cardiac lymphoma (PCL) is an even rarer subset. A definite diagnosis can be delayed, which increases the likelihood of a poor prognosis. We report a case involving a 64-year-old male who presented with dyspnea, palpitation, and third-degree atrioventricular block (AVB) secondary to primary cardiac B-cell lymphoma that was diagnosed via endomyocardial biopsy (EMB) and multimodality imaging. Chemotherapy was initiated using rituximab, cyclophosphamide, vindesine, and prednisone (R-COP) followed by implantation of an artificial capsule pacemaker. Third-degree AVB vanished, and the subsequent cycle of treatment was adjusted as R-CDOP (rituximab, cyclophosphamide, doxorubicin liposome, vindesine, and prednisone), with aspirin and rosavastatin to prevent ischemic events. So far, the patient had a good clinical course and normal electrocardiogram. This case underscores the importance of EMB in the diagnosis of heart neoplasms. It is worth noting that anthracycline is not contraindicated in PCL.

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Section: Discussionmentioning

confidence: 99%

Case report: Complete atrio-ventricular block successfully reversed in newly diagnosed primary cardiac B-cell lymphoma

Mao

Xu²,

Zhu³

et al. 2023

Front. Med.

View full text Add to dashboard Cite

show abstract

“…In this issue of JACC: Case Reports, Mandal et al. (11) describe a successful diagnosis and treatment of a cardiac lymphoma using tailored dose-attenuated chemotherapy, showing the importance both of multimodality imaging and multidisciplinary team work within cardio-oncology. Cardiac tumors represent arguably the most traditional part of cardio-oncology; however, the complexity of diagnosis and management highlights the evolution of both specialties and even more so the importance of collaboration.…”

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confidence: 99%