Complete Remission of a Diffuse Pontine Glioma

Lenard, H. C.; Engelbrecht, V.; Janßen, Gisela; Wechsler, W.; Tautz, Ch.

doi:10.1055/s-2007-973589

Cited by 38 publications

(29 citation statements)

References 2 publications

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“…12 Lenard et al have described 1 patient with diffuse pontine glioma diagnosed at age 23 months who experienced complete resolution of his tumor at age 6.6 years. 19 This patient presented with signs and symptoms for 12 months. Stereotactic biopsy of the tumor yielded a diagnosis of fibrillary astrocytoma (World Health Organization grade 2).…”

Section: Discussionmentioning

confidence: 98%

Young age may predict a better outcome for children with diffuse pontine glioma

Broniscer

Laningham

Sanders

et al. 2008

Cancer

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BACKGROUND.Because diffuse pontine glioma (DPG) is rare among young children, the outcome of affected patients is unknown.METHODS.The authors reviewed clinical and radiologic characteristics of all children aged <3 years with DPG who were evaluated at their institution. Inclusion followed standard magnetic resonance imaging criteria for the diagnosis of DPG.RESULTS.The median age at diagnosis in 10 patients was 2.2 years (range, 0.8–2.7 years). The median interval between the onset of symptoms and diagnosis was 2.5 months. All patients presented with cranial nerve palsy with (n = 7) or without (n = 3) other neurologic deficits attributable to brainstem involvement. All patients had pons‐based tumors involving >50% of this brainstem segment. Histologic confirmation was attempted in 2 patients who had atypical radiologic features at diagnosis. Four patients initially were observed only. All patients received therapy, which consisted of radiation therapy (RT) (n = 2), RT and chemotherapy (n = 6), or chemotherapy only (n = 2). Four patients died of tumor progression after a median of 0.7 years (range, 0.5–3.7 years). Six patients have survived for a median of 2.3 years (range, 0.9–8 years). The 3‐year progression‐free and overall survival rates were 45% ± 19% and 69% ± 19%, respectively.CONCLUSIONS.Children aged <3 years with DPG potentially may fare better than older patients with the same diagnosis despite the use of similar therapy. The current results suggested that DPG in younger children may be distinct biologically from similar tumors in older age groups. Cancer 2008. © 2008 American Cancer Society.

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Section: Discussionmentioning

confidence: 98%

Young age may predict a better outcome for children with diffuse pontine glioma

Broniscer

Laningham

Sanders

et al. 2008

Cancer

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“…Brain tumors that show spontaneous regression include low grade tumors of the hypothalamicchiasmatic region and diffuse brainstem gliomas. Lenard et al and Thompson et al have reported rare cases of spontaneous remission of diffuse brainstem lesions [10,11]. Schmandt et al reviewed 22 patients in whom regression of astrocytomas had occurred.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of a Suspected Temporal lobe Glioblastoma Multiforme and its Re-appearance at a Different Site

Gandhoke¹,

Ansari²,

Syal³

et al. 2017

JCR

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Background: Spontaneous regression of cancer is rarely seen in brain tumors. We report a spontaneous regression of a suspected temporal lobe glioblastoma multiforme (GBM) and its re-appearance at a different site within a period of six months. Case Report: A 45 year old male presented with complaint of headache since four months and nausea, vomiting and blurring of vision since last one month. Radiological imaging was suggestive of a right temporal lobe lesion most probably high grade glioma. The patient did not undergo surgery due to personal reasons. He presented again, six months later, with exaggeration of previous symptoms. Fresh radiological imaging revealed a right parietal lobe lesion with no lesion in the previous site. Patient underwent surgery and histopathological examination was suggestive of grade IV glioblastoma. Conclusion: Spontaneous regression of a glioblastoma, to our knowledge, has never been reported in the world literature. This case report highlights the need to look for newer aspects of tumor biology in GBM.

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“…Most tumors occurred in the visual pathway system with extension into the hypothalamus; some were restricted to the hypothalamus or were located in the thalamus and brainstem. Ten cases were examined pathologically with a diagnosis of juvenile pilocytic astrocytoma in 7 [4, 8, 10], grade I astrocytoma in 1 [11]and grade II astrocytoma in 2 [7, 12]. In the remaining 12 cases, the diagnosis of glioma was presumptive or not further specified.…”

Section: Discussionmentioning

confidence: 99%

“…Prior to the regression, 7 of the 22 patients underwent a biopsy of their tumor [4, 10, 11, 12], 4 patients underwent partial tumor resection [7, 8, 13], 1 had a resection of an unrelated cerebral astrocytoma [5]and 3 received ventriculoperitoneal shunts at the time of their biopsy or surgery [8, 11, 12]. However, our case and others showed regression quite some time after surgery, suggesting that involution may not be directly related to the surgery.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous Regression of Low-Grade Astrocytomas in Childhood

et al. 2000

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An 8-year-old boy with neurofibromatosis type 1 (NF1) and a biopsy-proven juvenile pilocytic astrocytoma of the hypothalamic/chiasmatic region was followed with serial MRIs over 4 years. Spontaneous tumor regression was followed by progression and biopsy; 6 months later, the tumor regressed again. This bimodal regression is rare, but highlights the variable natural history of low-grade gliomas in children with NF1 and the difficulty in evaluating response of such tumors to therapy.

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Complete Remission of a Diffuse Pontine Glioma

Cited by 38 publications

References 2 publications

Young age may predict a better outcome for children with diffuse pontine glioma

Young age may predict a better outcome for children with diffuse pontine glioma

Spontaneous Regression of a Suspected Temporal lobe Glioblastoma Multiforme and its Re-appearance at a Different Site

Spontaneous Regression of Low-Grade Astrocytomas in Childhood

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