Complete remission of gastric Burkitt’s lymphoma aftereradication of Helicobacter pylori

Abstract

Burkitt's lymphoma is a highly aggressive nonHodgkin lymphoma, often presenting in extra-nodal sites. It generally has a poor spontaneous outcome and needs aggressive treatment with systemic and intrathecal chemotherapy. Occurrence at the gastric site is rare. We report the case of a 39-year old woman who presented with a prominent ulcerated lesion of the antrum corresponding histologically to a Burkitt's lymphoma associated with Helicobacter pylori (H Ulcer healing and tumour regression with a complete histological response were obtained 8 wk after H pylori eradication. In spite of this complete remission, taking into account the high risk of recurrence, the patient received systemic and intrathecal chemotherapy. Two years later, the patient remained in complete remission. This is the first report of a gastric Burkitt's lymphoma responding to H pylori eradication. These findings raise the question of the potential role of H pylori in the pathogenesis of some gastric Burkitt's lymphomas, and show the importance of searching for and eradicating the bacteria in combination with conventional chemotherapy regimens.

Complete Remission of Burkitt Lymphoma After Surgical Excision: A Case Report

“…There is only six publications can be found in the literature [3][4][5][6][7][8]. Our case however is different than those reports because of the sporadic type of the disease.…”

Gastrointestinal non-Hodgkin lymphomas

“…24,25 There are casuistic reports on H. pylori eradication efficacy in gastric BL (gBL) therapy. 26 Lymphomatoid granulomatosis (LG) typically involves the lungs and is rarely found in GI tract. It is an angiodestructive EBV(+) lymphoma with aggressive course and poor prognosis (OS below 2 years).…”

Pulmonary mucosa-associated lymphoid tissue lymphoma revisited

“…In the original observation of gastric MALT lymphoma, the malignant B-cell clone process initially required the presence of the H. pylori antigen in order to proliferate, with H. pylori being detected in almost 90% of gastric biopsies from patients with gastric MALT lymphoma [14,15], and its eradication leading to complete and prolonged disease remission in 60-80% of early-stage gastric MALT lymphoma cases. H. pylori eradication has also been reported to be effective in localised gastric DLBCL [12,14,16]. However, some recent studies show an increasing rate of H. pylori-negative patients of up to 30-50% of gastric MALT lymphoma cases [17].…”