Complete remission of Hodgkin Lymphoma after a concurrent infection with COVID-19: systematic review and meta-analysis

Yousif, Nasser Ghaly

doi:10.52113/1/1/2022-57-67

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…Additionally, the inflammasome NLRP3, a multiprotein complex crucial to the host defense, is highly activated in COVID-19 patients. Inflammasome-induced cytokines IL-1β and IL-18 also contribute to cytokine storm, and sustained NLRP3 inflammasome activation is directly associated with the disease's severity [25].…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin and C-Reactive protein levels among COVID-19 patients in Sulaymaniyah

2023

MMJ

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COVID-19 is a viral disease that affects multiple body organs. The objective of this study is Investigating the role of PCT and CRP in predicting the outcome of patients with COVID-19. Cross-sectional prospective study including 135 patients with SARS-CoV-2 confirmed by RT-PCR. Serum level of PCT and CRP are measured at admission and on day 10 post-admission. Patients are followed up for one month. The mean level of PCT on day 1 was 0.1±0.28 ng/ml compared with 0.3±1.27 ng/ml on day 10. Respectively, the mean serum level of CRP on day 1 and day 10 was 113.57±89.88mg/L and 44.76±43.29 mg/L. At admission, the mean serum level of PCT and CRP in dead patients was 0.22±0.6 ng/ml and 164.0±105.59 mg/L, respectively compared with 0.07±0.08 ng/ml and 101.42±82.03 mg/L, respectively in the survived group. After 10 days of admission, the median serum level of PCT and CRP in dead patients was 1.5±2.74 ng/ml and 70.9±57.87 mg/L. respectively compared with 0.13±0.23 ng/ml and 37.7±34.87 mg/L, respectively in the survived patients. In conclusion, the serum level of PCT and CRP increases from admission to day 10 post-admission, and they are considered as indicators of severe inflammatory response and could increase mortality risk.

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Section: Introductionmentioning

confidence: 99%

Procalcitonin and C-Reactive protein levels among COVID-19 patients in Sulaymaniyah

2023

MMJ

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“…Studies have also revealed a potential benefit after the implantation of bone marrow containing osteogenic precursors into the necrotic lesions [ 9 ]. Bone marrow-derived mesenchymal stem cells (BMSCs) differentiate into various cell lineages of mesodermal origins, such as bone, cartilage, muscle, and adipocytes [ 10 – 13 ]. Red bone marrow includes not just hematopoietic elements but also stem cells containing osteogenic bone cell precursors.…”

Section: Introductionmentioning

confidence: 99%

Autologous hematopoietic bone marrow and concentrated growth factor transplantation combined with core decompression in patients with avascular necrosis of the femoral head

Yousif

Kilabi

Hatem³

et al. 2023

JMedLife

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The study aimed to assess the effectiveness of autologous hematopoietic bone marrow and concentrated growth factor (CGF) transplantation and core decompression in patients with avascular necrosis of the femoral head (ANFH). We performed a single-center prospective study on 31 patients with non-traumatic early-stage (stage I to III) ANFH based on the 1994 classification of the Association Research Circulation Osseous (ARCO). The patients were subjected to bone marrow aspiration from the posterior iliac crest, separation, and concentration of growth factors from the bone marrow aspirate, core decompression of the femoral head, and injection of hematopoietic bone marrow and CGFs into the necrotic lesion. Patients were evaluated using the visual analogue scale, the WOMAC questionnaire, and X-ray and MRI examinations of the hip joints before, at 2, 4, and 6 months after the intervention. Patients had a mean age of 33 years (range 20–44 years), 19 (61%) of them being male and 12 (39%) females. The presentation of the disease was bilateral in 21 patients and unilateral in 10 patients. The main cause of ANFH was steroid treatment. The mean VAS and WOMAC scores were 48.37 (SD: 14.67) out of 100, and the mean VAS pain score was 50.83 out of 100 (SD: 20.46), respectively, before transplant. This value significantly improved to 22.31 (SD 12.12) of 100, and the mean VAS pain score was 21.31 of 100 (SD: 20.46) (P=0.04). MRI showed a significant improvement (P=0.012). Our results suggest that autologous hematopoietic bone marrow and CGFs transplantation with core decompression have a beneficial effect in early-stage ANFH.

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COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches

Kakavandi,

Hajikhani,

Azizi

et al. 2024

Cell Commun Signal

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Extensive research in countries with high sociodemographic indices (SDIs) to date has shown that coronavirus disease 2019 (COVID-19) may be directly associated with more severe outcomes among patients living with haematological disorders and malignancies (HDMs). Because individuals with moderate to severe immunodeficiency are likely to undergo persistent infections, shed virus particles for prolonged periods, and lack an inflammatory or abortive phase, this represents an overall risk of morbidity and mortality from COVID-19. In cases suffering from HDMs, further investigation is needed to achieve a better understanding of triviruses and a group of related variants in patients with anemia and HDMs, as well as their treatment through vaccines, drugs, and other methods. Against this background, the present study aimed to delineate the relationship between HDMs and the novel COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Besides, effective treatment options for HDM cases were further explored to address this epidemic and its variants. Therefore, learning about how COVID-19 manifests in these patients, along with exploiting the most appropriate treatments, may lead to the development of treatment and care strategies by clinicians and researchers to help patients recover faster.

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Complete remission of Hodgkin Lymphoma after a concurrent infection with COVID-19: systematic review and meta-analysis

Cited by 7 publications

References 29 publications

Procalcitonin and C-Reactive protein levels among COVID-19 patients in Sulaymaniyah

Procalcitonin and C-Reactive protein levels among COVID-19 patients in Sulaymaniyah

Autologous hematopoietic bone marrow and concentrated growth factor transplantation combined with core decompression in patients with avascular necrosis of the femoral head

COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches

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