Complete remission of palmoplantar psoriasis through Helicobacter pylori eradication: a case report

Hübner, Martin; Tenbaum, Stephan P.

doi:10.1111/j.1365-2230.2007.02634.x

Cited by 25 publications

(19 citation statements)

References 4 publications

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“…Notably, psoriasis was also improved in patients receiving only eradication treatment [75] . This study confirmed anecdotal reports or case studies showing that eradication therapy improves psoriasis [73,76] .…”

Section: Psoriasissupporting

confidence: 93%

Helicobacter pyloriand autoimmune disease: Cause or bystander

Smyk¹,

Κουτσουμπασ²,

Mytilinaiou³

et al. 2014

WJG

153

108

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Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of autoimmune gastritis. However, a considerable number of reports have attempted to link H. pylori infection with the development of extra-gastrointestinal autoimmune disorders, affecting organs not immediately relevant to the stomach. This review discusses the current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases. We discuss epidemiological, serological, immunological and experimental evidence associating this pathogen with autoimmune diseases. Although over one hundred autoimmune diseases have been investigated in relation to H. pylori, we discuss a select number of papers with a larger literature base, and include Sjögrens syndrome, rheumatoid arthritis, systemic lupus erythematosus, vasculitides, autoimmune skin conditions, idiopathic thrombocytopenic purpura, autoimmune thyroid disease, multiple sclerosis, neuromyelitis optica and autoimmune liver diseases. Specific mention is given to those studies reporting an association of anti-H. pylori antibodies with the presence of autoimmune disease-specific clinical parameters, as well as those failing to find such associations. We also provide helpful hints for future research.

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Section: Psoriasissupporting

confidence: 93%

Helicobacter pyloriand autoimmune disease: Cause or bystander

Smyk¹,

Κουτσουμπασ²,

Mytilinaiou³

et al. 2014

WJG

153

108

View full text Add to dashboard Cite

show abstract

“…Some authors described marked improvement and/or remission of the refractory disease following proven bacteria eradication [19,20], whereas others consider the approach to be of no benefit to psoriatic individuals [21]. For example, Dauden et al [21] observed no improvement of psoriatic lesions, despite successful H. pylori eradication.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis vulgaris and digestive system disorders: is there a linkage?

Pietrzak

Jastrzębska²,

Chodorowska³

et al. 2010

Folia Histochem Cytobiol.

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Psoriasis is well-known immune-mediated skin disease often associated with co-morbidities, including dyslipidaemia and obesity. Few reports imply that the disease might be also related to pathology of mucosal surfaces, especially that of the digestive system. The authors present a case of psoriasis and concurrent digestive system abnormalities, and review the literature regarding the topic. A 40-year-old man suffered from an exacerbation of exudative psoriasis for about 6 months. Topical antipsoriatics proved ineffective and the disease gradually progressed to a severe disseminated form. Subsequent detailed examinations revealed persistent gastroduodenitis due to H. pylori infection, pancreatic dysfunction and fatty change of the liver, although the patient denied any gastrointestinal symptoms. As a result appropriate treatment of the diagnosed digestive system disorders was added to topical antipsoriatic therapy. Within 2 weeks of treatment clinical symptoms and laboratory signs showed a marked trend to normalisation. The presented medical history seems to suggest that there may be some kind of interplay between psoriasis and digestive system disorders.

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“…1 Helicobacter pylori (H. pylori) is a microaerophilic gram negative bacteria colonized in the stomach 3 leading to contamination of 50% of worldwide population. 4 Currently it has been shown that H. pylori may be related to various non-gastrointestinal disorders including chronic urticaria 5-7 , roseace 5-8 , psoriasis 8,9 , Schönlein-Henoch purpura 10 , Behçet disease 11,12 , chronic itching 13 , progressive systemic sclerosis 14,15 , Sjögren syndrome 16,17 , and sweet syndrome . 18 Most of these diseases have shown partial or complete improvement after H. pylori eradication.…”

Section: Introductionmentioning

confidence: 99%

“…18 Most of these diseases have shown partial or complete improvement after H. pylori eradication. 7,9,19-21 Different mechanisms have been proposed including; formation of antigen-antibody complexes and cross-reactive antibodies with molecular behavior pattern. 21-23 H. pylori would promote local inflammatory and chronic immune responses 24-26 leading to release of inflammatory mediators including interleukin-1, tumor necrosis factor alpha (TNF-α), interferon (INF) gamma, leukotriene (LT) C4, and platelet-activating factors (PAF).…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter Pylori Infection and Alopecia Areata: A Study in Iranian Population

Behrangi

Mansouri

Agah

et al. 2017

Middle East J Dig Dis

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BACKGROUND Alopecia areata is an immune mediated inflammatory hair loss, which occurs in all ethnic and age groups, and both sexes. However no significant etiology has been known for this disease. Helicobacter pylori (H. pylori) , is an organism colonized in gastric mucosa. This bacterium has been associated with certain extra-digestive dermatological conditions. The causal relationship between alopecia areata and H. pylori infection has been discussed in literature. Therefore, we conducted this study to evaluate the prevalence of H. pylori infection in patients with alopecia areata and assess the risk of this infection in patients with this disease in order to determine its potential roles in the physiopathology of this disease. METHODS Between 2014 and 2015, we prospectively studied 81 patients with alopecia areata and 81 healthy volunteers with similar age and sex. Patients without any history of H. pylori infection were included in the study and underwent urease breath test. All results were analyzed using SPSS software (version 21.0) and p value<0.05 was considered as statistically significant. RESULTS 81 patients and 81 controls with the mean age of 34.9±11.6 and 38.2±13.4 years were studied (p=0.097). 48 (59.3%) and 45 (55.6%) individuals were male, in cases and control groups respectively (p =0.634). The result of urea breath test (UBT) was positive in 43 (53.1%) patients in cases and 27 (33.3%) individuals in control group, which was significantly different (p =0.011). The risk of H. pylori infection in alopecia areata was 2.263 (95% CI: 1.199-4.273). CONCLUSION The results of our study showed significant difference between H. pylori infection in individuals with and without alopecia areata, which shows that H. pylori contamination may be effective in physiopathology of alopecia areata. Therefore these results should be tested in large multivariable cohorts and controlled trials to reach more accurate evidence in the future and to generalize this idea to larger population.

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Complete remission of palmoplantar psoriasis through Helicobacter pylori eradication: a case report

Cited by 25 publications

References 4 publications

Helicobacter pyloriand autoimmune disease: Cause or bystander

Helicobacter pyloriand autoimmune disease: Cause or bystander

Psoriasis vulgaris and digestive system disorders: is there a linkage?

Association between Helicobacter Pylori Infection and Alopecia Areata: A Study in Iranian Population

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