Complete resolution of facial molluscum contagiosum in a HIV‐infected patient by antiretroviral therapy

Motegi, Sei‐ichiro; Sekiguchi, Akiko; Ishikawa, Osamu

doi:10.1111/1346-8138.14090

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…However, this process requires administration of immunosuppressive drugs that prevent the hyperactive immune system in patient's body. Similarly, other multipotent stem cells such as mesenchymal stem cells (MSCs), [56] adipose stem cells (ASCs), [57] and human umbilical cord blood (hUCBs) [58] have revealed remarkable regenerative potential for the treatment of chronic wounds. In view of this, Bliley et al [59] found an improved messenger RNA (mRNA) expression ratio of type III to type I collagen, vascularity and collagen deposition, after ASCs transplantation in burn wounds.…”

Section: Cell Deliverymentioning

confidence: 99%

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

2021

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With all the advances in tissue engineering for construction of fully functional skin tissue, complete regeneration of chronic wounds is still challenging. Since immune reaction to the tissue damage is critical in regulating both the quality and duration of chronic wound healing cascade, strategies to modulate the immune system are of importance. Generally, in response to an injury, macrophages switch from pro‐inflammatory to an anti‐inflammatory phenotype. Therefore, controlling macrophages’ polarization has become an appealing approach in regenerative medicine. Recently, hydrogels‐based constructs, incorporated with various cellular and molecular signals, have been developed and utilized to adjust immune cell functions in various stages of wound healing. Here, the current state of knowledge on immune cell functions during skin tissue regeneration is first discussed. Recent advanced technologies used to design immunomodulatory hydrogels for controlling macrophages’ polarization are then summarized. Rational design of hydrogels for providing controlled immune stimulation via hydrogel chemistry and surface modification, as well as incorporation of cell and molecules, are also dicussed. In addition, the effects of hydrogels’ properties on immunogenic features and the wound healing process are summarized. Finally, future directions and upcoming research strategies to control immune responses during chronic wound healing are highlighted.

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