Complete sequence characterization of isolates of Getah virus (genus Alphavirus, family Togaviridae) from China

Zhai, You-gang; Wang, Huanyu; Sun, Xiaohong; Fu, Shihong; Wang, Huanqin; Attoui, Houssam; Tang, Qing; Liang, Guodong

doi:10.1099/vir.0.83607-0

Cited by 65 publications

(52 citation statements)

References 39 publications

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“…It can cause disease in livestock but there are no reports indicating that GETV is associated with human diseases (17)(18)(19)(20). GETV has been isolated from mosquitoes collected in the southern, northern, southwestern, and northwestern parts of China in recent years, demonstrating that the virus is widespread in China (4,13,21,22). In 2005, GETV was isolated from An.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Mosquitoes and Mosquito-Borne Viruses along the China-Myanmar Border in Yunnan Province

Feng

Zhang

et al. 2012

Jpn J Infect Dis

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SUMMARY: A total of 54,673 mosquitoes were collected at 11 sites located near the China-Myanmar border in the western part of Yunnan Province during July and August 2007. There were 29 species in 4 genera identified from the collections, including 12 species of Culex, 12 species of Anopheles, 3 species of Aedes, and 2 species of Armigeres. Culex tritaeniorhynchus Giles (67.9z, 37,119/54,673) and Anopheles sinensis Wiedemann (25.9z,14,170/54,673) were the most abundant species in this investigation. Virus was isolated using BHK-21 and C6/36 cells from 22 of 510 mosquito pools. Isolates included Japanese encephalitis virus (JEV) and Getah virus (GETV), which were identified by serological and molecular methods. Twenty JEV strains were isolated from Cx. tritaeniorhynchus (15 isolates), An. sinensis (3 isolates), and Armigeres subalbatus Coquillett (2 isolates), and 2 GETV strains were isolated from Culex pseudovishnui Colless and Cx. tritaeniorhynchus. This study suggests that Ar. subalbatus is a potentially important local vector because of the high JEV infection ratio found in this species. Enzootic JEV transmission persists in this area and therefore, surveillance for human disease caused by JEV and GETV should be conducted in the region.

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Section: Discussionmentioning

confidence: 99%

Distribution of Mosquitoes and Mosquito-Borne Viruses along the China-Myanmar Border in Yunnan Province

Feng

Zhang

et al. 2012

Jpn J Infect Dis

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“…Previous studies have shown that the genomes of several GETV strains contain insertions or deletions in proteincoding or noncoding regions (Wen et al 2007, Zhai et al 2008). However, we found no insertions or deletions in the genome sequence of strain 12IH26.…”

Section: Analysis Of Getv Genome Sequence and Phylogenetic Characterimentioning

confidence: 99%

Complete Genome Sequencing and Phylogenetic Analysis of a Getah Virus Strain (GenusAlphavirus, FamilyTogaviridae) Isolated fromCulex tritaeniorhynchusMosquitoes in Nagasaki, Japan in 2012

Kobayashi

Isawa

Ejiri

et al. 2016

Vector-Borne and Zoonotic Diseases

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Getah virus (GETV; genus Alphavirus, family Togaviridae) is a mosquito-borne virus known to cause disease in horses and pigs. In 2014, for the first time in ∼30 years, a sudden GETV outbreak occurred among racehorses in Ibaraki, Japan. Two years before this outbreak, we obtained multiple GETV isolates from Culex tritaeniorhynchus mosquitoes collected in Nagasaki, Japan and determined the whole genome sequence of GETV isolate 12IH26. Our phylogenetic analysis of GETV strains revealed that the isolate 12IH26 forms a robust clade with the epidemic strains 14-I-605-C1 and 14-I-605-C2 isolated from horses in the 2014 outbreak in Ibaraki. Furthermore, the complete genomic sequence of the isolate 12IH26 was 99.9% identical to those of the 2014 epidemic strains in Ibaraki. Phylogenetic analysis also showed that the recent Japanese GETV strains, including the isolate 12IH26, are closely related to the Chinese and South Korean strains rather than the previous Japanese strains, suggesting that GETV strains may be transported from overseas into Japan through long-distance migration of the infected mosquitoes or migratory birds.

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“…Getah virus is transmitted mainly among horses and pigs, and it has not been linked to human illness (12)(13)(14). Also, M1 does not cause apparent disease symptoms in mice or rats, even on administration of doses up to 3 × 10 7 pfu per mouse or 3 × 10 8 pfu per rat.…”

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confidence: 99%

Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers

Lin¹,

Zhang²,

Liang³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

124

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Oncolytic virotherapy is a growing treatment modality that uses replicating viruses as selective antineoplastic agents. Safety and efficacy considerations dictate that an ideal oncolytic agent would discriminate between normal and cancer cells on the basis of common genetic abnormalities in human cancers. Here, we identify a naturally occurring alphavirus (M1) as a novel selective killer targeting zinc-finger antiviral protein (ZAP)-deficient cancer cells. In vitro, in vivo, and ex vivo studies showed potent oncolytic efficacy and high tumor tropism of M1. We showed that the selectivity depends on ZAP deficiency by systematic identification. A large-scale multicenter pathology study using tissue microarrays reveals that ZAP is commonly deficient in human cancers, suggesting extensive application prospects for M1. Additionally, M1 killed cancer cells by inducing endoplasmic reticulum stress-mediated apoptosis. Our report provides novel insights into potentially personalized cancer therapy using oncolytic viruses.

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Complete sequence characterization of isolates of Getah virus (genus Alphavirus, family Togaviridae) from China

Cited by 65 publications

References 39 publications

Distribution of Mosquitoes and Mosquito-Borne Viruses along the China-Myanmar Border in Yunnan Province

Distribution of Mosquitoes and Mosquito-Borne Viruses along the China-Myanmar Border in Yunnan Province

Complete Genome Sequencing and Phylogenetic Analysis of a Getah Virus Strain (GenusAlphavirus, FamilyTogaviridae) Isolated fromCulex tritaeniorhynchusMosquitoes in Nagasaki, Japan in 2012

Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers

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