Complete Unilateral vs Partial Bilateral Endoscopic Lung Volume Reduction in Patients With Bilateral Lung Emphysema

Eberhardt, Ralf; Gompelmann, Daniela; Schuhmann, Maren; Reinhardt, Hannah; Ernst, Armin; Heußel, Claus Peter; Herth, Felix J.F.

doi:10.1378/chest.11-2886

Cited by 87 publications

(71 citation statements)

References 26 publications

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“…Results showed that procedure and devices were well tolerated but treatment without complete lobar occlusion in both upper lobes was ineffective in most of the patients. After this study Eberhardt et al confirmed that unilateral intrabronchial valve placement with complete occlusion is superior to bilateral partial occlusion [15]. Finally STELVIO study showed that the lack of collateral ventilation is essential for the success of BVR with valves [16].…”

Section: Unidirectional Endobronchial and Intrabronchial Valvesmentioning

confidence: 72%

Bronchoscopic treatment options for chronic obstructive pulmonary disease

Yıldızeli¹

2016

MMJ

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Chronic obstructive pulmonary disease (COPD) is a major cause of high mortality and morbidity worldwide. Symptoms of the disease are usually related with the results of pulmonary dynamic hyperinflation. Treatment options are classified as invasivenoninvasive and mostly tend to be palliative. Lung volume reduction techniques are invasive part of the treatment and can be performed by surgical or bronchoscophic methods. Because of the low complication rates bronchoscophic methods became more popular in recent years. Patients presenting with severe air trapping and thoracic hyperinflation have the greatest potential to derive benefit from volume reduction procedures. Assessment of patients should ideally include cardiological evaluation, high resolution CT scan, ventilation and perfusion scintigraphy, full pulmonary function tests, and cardiopulmonary exercise testing.There are three main groups of bronchoscophic volume reduction, direct effect on lung parenchyma, airway bypass and blocking the airways. Indications and contraindications are different for each modality and device. Patients who have deterioration despite habitual changes and medical therapies should be evaluated for volume reduction procedures.

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Section: Unidirectional Endobronchial and Intrabronchial Valvesmentioning

confidence: 72%

Bronchoscopic treatment options for chronic obstructive pulmonary disease

Yıldızeli¹

2016

MMJ

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“…Eberhardt et al demonstrated that a unilateral procedure with the aim of a complete lobar occlusion is more effective than bilateral incomplete treatment [28]. Twenty two patients were enrolled and randomised in this study, 11 patients received unilateral IBV valve implantation and 11 patients bilateral upper-lobe implantation.…”

Section: Spiration Valvementioning

confidence: 97%

Endoscopic lung volume reduction in chronic obstructive airway disease using one-way valves

Kontogianni¹,

Eberhardt²

2017

Curr Thorac Surg

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Chronic obstructive airway disease (COPD) is a progressive, irreversible and debilitating disease causing lung hyperinflation. Apart from smoking cessation and conventional medical treatment, lung volume reduction surgery (LVRS) has been used for several years but it involves a major thoracic surgery with high incidence of postoperative complications. In the past decade, different approaches of minimally invasive endoscopic lung volume reduction (ELVR) have been developed which differ in indication, mechanism of action, reversibility and are divided into two groups: blocking and non-blocking devices. Summarizing, in comparison to LVRS, ELVR using valves is a less invasive alternative with the opportunity to improve shortness of breath, exercise capacity, and quality of life in the patients, who have reached the end of their conventional treatment options.

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“…An RCT involving 277 patients found that incomplete bilateral occlusion did not achieve a satisfactory TLVR (TLVR is only about 200 mL), and the treatment group displayed no significant improvement according to their SGRQ scores (25). Eberhardt et al compared the use of implanted IBVs in complete unilateral occlusion and incomplete bilateral occlusion (26). In 7 of 11 patients, complete occlusion resulted in collapse of the target lobe; in 11 patients with incomplete occlusion, none had atelectasis.…”

Section: Tlvrmentioning

confidence: 99%

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

Wang

et al. 2016

BST

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Complete Unilateral vs Partial Bilateral Endoscopic Lung Volume Reduction in Patients With Bilateral Lung Emphysema

Cited by 87 publications

References 26 publications

Bronchoscopic treatment options for chronic obstructive pulmonary disease

Bronchoscopic treatment options for chronic obstructive pulmonary disease

Endoscopic lung volume reduction in chronic obstructive airway disease using one-way valves

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

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