Complex Association of Sex Hormones on Left Ventricular Systolic Function: Insight into Sexual Dimorphism

Salem, Joe‐Elie; Nguyen, Lee S.; Hammoudi, Nadjib; G, Preudhomme; Hulot, Jean‐Sébastien; Leban, Monique; Funck‐Brentano, Christian; Touraine, Philippe; Isnard, R.; Bachelot, Anne; Chanson, Philippe; Salenave, Sylvie; Maitre, S. Christin; Bourcigaux, Nathalie; Jérôme, D.; Dahmoune, Nora; Polak, Michel; Léger, Juliane

doi:10.1016/j.echo.2017.10.017

Cited by 15 publications

(13 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In solid organ transplantation, preclinical studies showed an increased lactate production in female rat liver transplant due to sexual hormones, specifically 17 beta-estradiol and progesterone. [20][21][22] We acknowledge several limitations. [17][18][19] Other hormones have yet to be explored, but several studies suggest a potential complex role of sex hormones in cardiac physiology.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of recipient gender and donor-specific antibodies on antibody-mediated rejection after heart transplantation

Nguyen

Coutance

Salem

et al. 2019

American Journal of Transplantation

Self Cite

View full text Add to dashboard Cite

Gender‐difference regarding antibody‐mediated rejection (AMR) after heart transplantation has been described. However, no study accounted for the presence of preformed donor‐specific antibodies (pfDSA), a known risk factor of AMR, more common among women than men. In a single‐institution 6‐year cohort (2010‐2015), time to AMR was assessed, comparing men with women by survival analysis with a 1‐year death‐censored follow‐up. All AMRs were biopsy proven. Confounding variables that were accounted for included mean intensity fluorescence (MFI) of pfDSA, recipient age, HLA‐, size‐ and sex‐mismatch. 463 patients were included. Overall incidence of AMR was 10.3% at 1 year. After adjusting for confounding variables, independent risk factors of AMR were female recipient gender (adjusted hazard‐ratio [adj. HR] = 1.78 [1.06‐2.99]), P = .03) and the presence of pfDSA (adj. HR = 3.20 [1.80‐5.70], P < .001). This association remained significant when considering pfDSA by their MFI; female recipient gender had an adj. HR = 2.2 (P = .026) and MFI of pfDSA (per 1 MFI‐increase) adj. HR = 1.0002 (P < .0001). In this cohort, women were at higher risk of AMR than men and this risk increase was additive to that of pfDSA. These findings may suggest a gender‐related difference in the severity of pfDSA.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[17][18][19] Other hormones have yet to be explored, but several studies suggest a potential complex role of sex hormones in cardiac physiology. [20][21][22] We acknowledge several limitations. First, because of the single-center nature of the study, results may not be generalized easily.…”

Section: Discussionmentioning

confidence: 99%

Effect of recipient gender and donor-specific antibodies on antibody-mediated rejection after heart transplantation

Nguyen

Coutance

Salem

et al. 2019

American Journal of Transplantation

Self Cite

View full text Add to dashboard Cite

show abstract

“…For every patient with CAH, a healthy control matched for sex, age, and smoking status was prospectively included in the CARDIOHCS study (NCT01807364) between May 2011 and August 2015 (8,9,10). Patients with CAH and healthy controls were all assessed at the Clinical Investigation Center Paris-Est (CIC-1421, Pitie-Salpetriere University Hospital, Paris, France).…”

Section: Study Population and Settingmentioning

confidence: 99%

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

Nguyen

Rouas‐Freiss

Funck‐Brentano

et al. 2019

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Background HLA-G is an immune checkpoint molecule, naturally expressed during pregnancy, playing a critical role in the tolerance of the fetal semi-allograft from the maternal immune system. While HLA-G expression levels are associated with progesterone, the influence of other hormones is still unclear. Congenital adrenal hyperplasia (CAH) represents an adequate model to study the hormonal influence on biomarkers as it leads to impaired cortisol biosynthesis and increased progesterone and androgens production due to 21-hydroxylase enzyme deficiency. Methods In a cross-sectional study of CAH patients matched on sex and age with healthy control, the association between circulating levels of soluble HLA-G and hormones was assessed by use of non-parametric analyses tests. Multivariable linear regressions were performed on normalized data. Results Overall, 83 CAH patients and 69 healthy controls were included. Among CAH patients, all were under glucocorticoid and 52 (62.6%) were under mineralocorticoid supplementation. Compared to controls, CAH patients had increased HLA-G levels (15 vs 8 ng/mL, P = 0.02). In controls, HLA-G level was independently associated with progesterone and estradiol (β = 0.44 (0.35–1.27) and −0.44 (−0.94, −0.26) respectively, both P values = 0.001). In CAH patients, HLA-G level was independently associated with mineralocorticoid supplementation dosage (β = 0.25 (0.04–0.41), P = 0.001) and estradiol (β = −0.22 (−0.57, −0.02), P < 0.001). Conclusion CAH patients had higher HLA-G levels than healthy controls. HLA-G level was positively associated with progesterone and corticosteroid supplementation, and negatively with estradiol. The association between mineralocorticoid, renin and HLA-G levels may suggest a role of the renin-angiotensin system in the expression of soluble HLA-G.

show abstract

“…On the other hand, investigation showed that female patients had significantly higher aldosterone levels than male patients, and investigators found a positive correlation between aldosterone levels and RV dilatation only in female but not in male patients . A recently published study revealed the association between sex hormones and left ventricular longitudinal strain …”

Section: Introductionmentioning

confidence: 99%

Does gender affect the association between right ventricular strain and arterial hypertension?

Tadić

Cuspidi

Ivanović

et al. 2018

J of Clinical Hypertension

View full text Add to dashboard Cite

The importance of right ventricular (RV) structure and function in cardiovascular and total morbidity and mortality has been confirmed previously. The purpose of this study was to evaluate the influence of gender on RV structure and function in untreated hypertensive patients. This cross-sectional study included 243 subjects who underwent 24-hour ambulatory blood pressure (BP) monitoring and comprehensive echocardiographic examination including strain evaluation. There was no difference in RV diameter between hypertensive and normotensive women and men. RV wall thickness, right atrial volume index (RAVI), and tricuspid E/e' ratio were significantly higher in hypertensive women and men than in their normotensive counterparts. RV global longitudinal and RV free wall longitudinal strains were significantly lower in hypertensive women and men than in their normotensive counterparts. Arterial hypertension affected RV wall thickness, RAVI, tricuspid E/e', and RV longitudinal strain. Gender affected RV diameter, RAVI, tricuspid E/e', and RV longitudinal strain, whereas hypertension-gender interaction affected RAVI, E/e', and RV longitudinal strain. The 24-hour systolic BP and LV mass index were independently associated with RV free wall longitudinal strain. RV wall thickness was independently associated with RV free wall longitudinal strain only in women, and tricuspid E/e' was independently associated only in men. In conclusion, RV longitudinal strain was significantly decreased in hypertensive patients in both sexes. Hypertensive men suffered more evident RV mechanical changes than hypertensive women. Gender, arterial hypertension, and their interaction had the important role in RV structural and mechanical remodeling.

show abstract

Complex Association of Sex Hormones on Left Ventricular Systolic Function: Insight into Sexual Dimorphism

Abstract: These data support that the existence of sex dimorphism concerning left ventricular systolic cardiac function is significantly associated with testosterone levels.

Cited by 15 publications

References 48 publications

Effect of recipient gender and donor-specific antibodies on antibody-mediated rejection after heart transplantation

Effect of recipient gender and donor-specific antibodies on antibody-mediated rejection after heart transplantation

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

Does gender affect the association between right ventricular strain and arterial hypertension?

Contact Info

Product

Resources

About