This paper represents the design of a class-F power amplifier (PA), its artificial neural network (ANN) model and a PA linearization method. The designed PA operates at 1.8 GHz with gain of 12 dB and 1dB output compression point (P1dB) of 36 dBm. The proposed ANN model is used to predict the output power of designed class-F PA as a function of input and DC power. This model utilizes the designed class-F PA as a block, which could be used in a desired linearization circuit. In addition, the power added efficiency (PAE) and the other specifications of a PA, related to power can be predicted using the proposed model. A simple feedforward technique is used to improve the linearity of designed PA. For verification, this linearization method is compared with presented neural network model simulations.The results show the improvement of P1dB from 36 to 41 dBm, which is predicted using the proposed model. Also, the PAE of the final linearized circuit PA is predicted.