We describe photonic crystal microcavities with very strong light-matter interaction to realize roomtemperature, equilibrium, exciton-polariton Bose-Einstein condensation (BEC). This goal is achieved through a careful balance between strong light trapping in a photonic band gap (PBG) and large exciton density enabled by a multiple quantum-well (QW) structure with a moderate dielectric constant. This approach enables the formation of a long-lived, dense 10 − μm − 1 − cm-scale cloud of exciton polaritons with vacuum Rabi splitting that is roughly 7% of the bare exciton-recombination energy. We introduce a woodpile photonic crystal made of Cd 0.6 Mg 0.4 Te with a 3D PBG of 9.2% (gap-to-central-frequency ratio) that strongly focuses a planar guided optical field on CdTe QWs in the cavity. For 3-nm QWs with 5-nm barrier width, the exciton-photon coupling can be as large as ℏΩ ¼ 55 meV (i.e., a vacuum Rabi splitting of 2ℏΩ ¼ 110 meV). The exciton-recombination energy of 1.65 eV corresponds to an optical wavelength of 750 nm. For N ¼ 106 QWs embedded in the cavity, the collective exciton-photon coupling per QW (ℏΩ= ffiffiffiffi N p ¼ 5.4 meV) is much larger than the state-of-the-art value of 3.3 meV, for the CdTe Fabry-Pérot microcavity. The maximum BEC temperature is limited by the depth of the dispersion minimum for the lower polariton branch, over which the polariton has a small effective mass of approximately 10 −5 m 0 , where m 0 is the electron mass in vacuum. By detuning the bare exciton-recombination energy above the planar guided optical mode, a larger dispersion depth is achieved, enabling room-temperature BEC. The BEC transition temperature ranges as high as 500 K when the polariton density per QW is increased to ð11a B Þ −2 , where a B ≃ 3.5 nm is the exciton Bohr radius and the exciton-cavity detuning is increased to 30 meV. A high-quality PBG can suppress exciton radiative decay and enhance the polariton lifetime to beyond 150 ps at room temperature, sufficient for thermal equilibrium BEC.