The authors conducted a single-center clinical study of the effectiveness of endoscopic vacuum therapy for suture failure after bariatric surgery. The algorithm of actions was proposed, and the manipulations technique was described. Vacuum therapy was used in combination with a polyurethane obturator. The effectiveness of the technique was confirmed by positive results with the recovery of 8 patients. Endoscopic vacuum treatment of suture failure within the proposed algorithm is an effective method for treating the life-threatening complication of bariatric surgery.