Complex Formation Between Ferric(III), Chromium(III), and Cupric(II) Metal Ions and (O,N) and (O,O) Donor Ligands with Biological Relevance in Aqueous Solution

Metal complexes of salicylhydroxamic acid and 1,10-phen-anthroline; equilibrium and antimicrobial activity studies

“…To determine the protonation and stability constants of SHAM, PHEN and their metal complexes, Hyperquad2008 was used to make nonlinear least square curve fitting based on experimental pH-potentiometric titration data as described in our previous work [17,[7][8][9][10][11][12][13][14]. Various models with possible compositions of complex species and estimation of its stability constants were proposed to the program.…”

“…These materials have been used as drugs and they are reported to possess a wide range of biological activities against bacteria, fungi and certain types of tumors. In a continuation of our research work oriented towards studying the acid-base and complexation equilibria of many biological oxygen and nitrogen donor drugs with different chelating property [7][8][9][10][11][12][13][14], the present work concerns the equilibrium studies and synthesis of some binary and mixed ligand complexes involving salicylhydroxamic acid, 1,10-phenanthroline.Most interest in the design of binary and ternary complexes as drugs has been centered on the area of antimicrobial and anticancer agents. Hereby, in this paper, we report the results of the equilibrium studies and synthesis of binary and ternary complexes of salicylhydroxamic acid (SHAM) and 1,10-phenanthroline (PHEN) (Scheme 1) as well as investigated their antibacterial and antifungal activities in order to orient future investigations towards the finding of new potent and safe antimicrobial drugs.…”

Complex formation constant of ferric ion with Gly, Pro-Hyp and Gly-Pro-Hyp

“…This result was similar to the results reported by Angkawijaya et al and Fazary et al, which stated that the [MA 3 ] complex of Fe(III) with a ligand, namely, ferulic acid, L-norleucine or gallic acid had the highest stability constant value and thus, it was a stable species. 25,26 However, an exception was observed for the log b value of [MA 3 ] with Gly-Pro-Hyp as the ligand, especially at the temperatures of 37 C and 40 C; [MA 2 H 2 ] was found to be more stable than [MA 3 ]. This might be due to the steric hindrance effect of Gly-Pro-Hyp, which was larger than those of Gly and Pro-Hyp; this inhibited the formation of the [MA 3 ] complex, especially at higher temperatures.…”

Complexes of 2,6-dihydroxybenzoic acid with divalent metal ions: Synthesis, crystal structure, spectral studies, and biological activity enhancement

“…The synthesis of organic ligand and metal ion is an interesting research field since the product complex may enhance the biological properties of the ligand [8][9][10][11][12]. To the best of our knowledge there is no study utilize combination of DHBA and metal ions in order to enhance the biological properties of DHBA.…”