Complex geometry and integrated macro-porosity: Clinical applications of electron beam melting to fabricate bespoke bone-anchored implants

Palmquist, Anders; Jolic, Martina; Hryha, Eduard; Shah, Furqan A.

doi:10.1016/j.actbio.2022.06.002

Cited by 43 publications

(17 citation statements)

References 149 publications

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“…Commercially, EBM is frequently utilized to fabricate highly porous metal implants, typically Ti6Al4V, for a broad range of orthopedic applications to allow for osseous ingrowth [ 140 ]. Hou et al combined an EBM-generated porous titanium prosthesis with an intramedullary nail in five patients with irregular segmental femoral defects.…”

Section: Future Directions For Addressing Bone Lossmentioning

confidence: 99%

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

et al. 2022

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The management and definitive treatment of segmental bone defects in the setting of acute trauma, fracture non-union, revision joint arthroplasty, and tumor surgery are challenging clinical problems with no consistently satisfactory solution. Orthopaedic surgeons are developing novel strategies to treat these problems, including three-dimensional (3D) printing combined with growth factors and/or cells. This article reviews the current strategies for management of segmental bone loss in orthopaedic surgery, including graft selection, bone graft substitutes, and operative techniques. Furthermore, we highlight 3D printing as a technology that may serve a major role in the management of segmental defects. The optimization of a 3D-printed scaffold design through printing technique, material selection, and scaffold geometry, as well as biologic additives to enhance bone regeneration and incorporation could change the treatment paradigm for these difficult bone repair problems.

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Section: Future Directions For Addressing Bone Lossmentioning

confidence: 99%

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

et al. 2022

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“…With the progress of early diagnosis, surgical techniques and design and manufacture of femoral prosthesis, limb salvage surgery has become the best choice for the treatment of femoral malignant tumor [ 1 ]. 3D-printed porous titanium alloy bone scaffolds have been applied more and more clinically due to their good mechanical and biological properties [ 2 ]. Porous titanium alloy can avoid the stress shielding effect caused by the mismatch between the stiffness of the scaffold and the bone tissue, and allow the bone tissue to grow into the inner part of the scaffold to form long-term biological fixation, which is a good bone defect repair material [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Design and performance analysis of 3D-printed stiffness gradient femoral scaffold

Liu

Deng

et al. 2023

J Orthop Surg Res

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Studies on 3D-printed porous bone scaffolds mostly focus on materials or structural parameters, while the repair of large femoral defects needs to select appropriate structural parameters according to the needs of different parts. In this paper, a kind of stiffness gradient scaffold design idea is proposed. Different structures are selected according to the different functions of different parts of the scaffold. At the same time, an integrated fixation device is designed to fix the scaffold. Finite element method was used to analyze the stress and strain of homogeneous scaffolds and the stiffness gradient scaffolds, and the relative displacement and stress between stiffness gradient scaffolds and bone in the case of integrated fixation and steel plate fixation. The results showed that the stress distribution of the stiffness gradient scaffolds was more uniform, and the strain of host bone tissue was changed greatly, which was beneficial to the growth of bone tissue. The integrated fixation method is more stable, less stress and evenly distributed. Therefore, the integrated fixation device combined with the design of stiffness gradient can repair the large femoral bone defect well.

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“…Metal additive manufacturing (AM), as a disruptive technology, has a huge potential to revolutionize the aerospace, biomedical, automotive, railway and defense industries with higher productivity and flexibility [1,2]. However, the lower fatigue strength and larger scatter in fatigue life induced by unpredictable manufacturing defects (e.g.…”

Section: Introductionmentioning

confidence: 99%

High-cycle fatigue life prediction of L-PBF AlSi10Mg alloys: a domain knowledge-guided symbolic regression approach

Yu,

Hu,

Kang

et al. 2023

Phil. Trans. R. Soc. A.

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The large scatter in high-cycle fatigue (HCF) life poses significant challenges to safe and reliable in-service assessment of additively manufactured metal components. Previous investigations have indicated that inherent manufacturing defects are a critical factor affecting the fatigue performance of the components, and the HCF life is significantly influenced by the geometric parameters of the critical defects inducing crack nucleation. Therefore, it is highly important to elucidate the correlation of the HCF life with the geometric parameters of critical defects. This study proposes a new fatigue life prediction model for laser additively manufactured AlSi10Mg alloys by including the combined effects of loading stress and defect geometries (size, location and morphology) in terms of domain knowledge-guided symbolic regression (SR). Domain knowledge is extracted from the semi-empirical Murakami, Z -parameter and X -parameter fatigue life models to establish the variable subtrees. The results show that compared with these semi-empirical models, the domain knowledge integration-based SR model has higher prediction accuracy and generalization ability. Moreover, compared with traditional ‘black box’ machine learning models, SR excels at balancing prediction accuracy and model interpretability, which provides useful insights into the relationship between fatigue life and defect geometries. This article is part of the theme issue 'Physics-informed machine learning and its structural integrity applications (Part 2)'.

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Complex geometry and integrated macro-porosity: Clinical applications of electron beam melting to fabricate bespoke bone-anchored implants

Cited by 43 publications

References 149 publications

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

Design and performance analysis of 3D-printed stiffness gradient femoral scaffold

High-cycle fatigue life prediction of L-PBF AlSi10Mg alloys: a domain knowledge-guided symbolic regression approach

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