Complex interplay of gut microbiota between obesity and asthma in children

Hu, Mingge; Zhao, Xiaoman; Liu, Yazun; Zhou, Huan; You, Yannan; Xue, Zheng

doi:10.3389/fmicb.2023.1264356

Cited by 2 publications

(2 citation statements)

References 182 publications

(175 reference statements)

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“…Recent research suggests that the gut microbiota may play a mediating role in the association between obesity and asthma [ 136 ]. Dysbiosis of the gut microbiota, which has been observed in both obesity and asthma, negatively affects lipid metabolism and immune response and induces chronic low-grade inflammation.…”

Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

“…Dysbiosis of the gut microbiota, which has been observed in both obesity and asthma, negatively affects lipid metabolism and immune response and induces chronic low-grade inflammation. This may indicate that it is a contributing factor in the pathogenesis of obesity-associated asthma, although the underlying mechanisms have not yet been fully investigated [ 136 ]. Figure 1 summarises the previously mentioned factors involved in the development of asthma or deterioration of control of pre-existing disease in children affected by obesity.…”

Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

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Not Only Metabolic Complications of Childhood Obesity

Ciężki,

Odyjewska,

Bossowski

et al. 2024

Nutrients

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The increasing incidence of obesity in the pediatric population requires attention to its serious complications. It turns out that in addition to typical, well-known metabolic complications, obesity as a systemic disease carries the risk of equally serious, although less obvious, non-metabolic complications, such as cardiovascular diseases, polycystic ovary syndrome, chronic kidney disease, asthma, thyroid dysfunction, immunologic and dermatologic conditions, and mental health problems. They can affect almost all systems of the young body and also leave their mark in adulthood. In addition, obesity also contributes to the exacerbation of existing childhood diseases. As a result, children suffering from obesity may have a reduced quality of life, both physically and mentally, and their life expectancy may be shortened. It also turns out that, in the case of obese pregnant girls, the complications of obesity may also affect their unborn children. Therefore, it is extremely important to take all necessary actions to prevent the growing epidemic of obesity in the pediatric population, as well as to treat existing complications of obesity and detect them at an early stage. In summary, physicians treating a child with a systemic disease such as obesity must adopt a holistic approach to treatment.

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Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

Not Only Metabolic Complications of Childhood Obesity

Ciężki,

Odyjewska,

Bossowski

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

Obesity and Asthma: Implementing a Treatable Trait Care Model

Mendes,

Garcia‐Larsen,

Moreira

2024

Clin Experimental Allergy

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Recognition of obesity as a treatable trait of asthma, impacting its development, clinical presentation and management, is gaining widespread acceptance. Obesity is a significant risk factor and disease modifier for asthma, complicating treatment. Epidemiological evidence highlights that obese asthma correlates with poorer disease control, increased severity and persistence, compromised lung function and reduced quality of life. Various mechanisms contribute to the physiological and clinical complexities observed in individuals with obesity and asthma. These encompass different immune responses, including Type IVb, where T helper 2 cells are pivotal and driven by cytokines like interleukins 4, 5, 9 and 13, and Type IVc, characterised by T helper 17 cells and Type 3 innate lymphoid cells producing interleukin 17, which recruits neutrophils. Additionally, Type V involves immune response dysregulation with significant activation of T helper 1, 2 and 17 responses. Finally, Type VI is recognised as metabolic‐induced immune dysregulation associated with obesity. Body mass index (BMI) stands out as a biomarker of a treatable trait in asthma, readily identifiable and targetable, with significant implications for disease management. There exists a notable gap in treatment options for individuals with obese asthma, where asthma management guidelines lack specificity. For example, there is currently no evidence supporting the use of incretin mimetics to improve asthma outcomes in asthmatic individuals without Type 2 diabetes mellitus (T2DM). In this review, we advocate for integrating BMI into asthma care models by establishing clear target BMI goals, promoting sustainable weight loss via healthy dietary choices and physical activity and implementing regular reassessment and referral as necessary.

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Complex interplay of gut microbiota between obesity and asthma in children

Cited by 2 publications

References 182 publications

Not Only Metabolic Complications of Childhood Obesity

Not Only Metabolic Complications of Childhood Obesity

Obesity and Asthma: Implementing a Treatable Trait Care Model

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