Complex Ions. I. The Identification of Complex Ions in Solution by Spectrophotometric Measurements

Vosburgh, W. C.; Cooper, Gerald R.

doi:10.1021/ja01847a025

Cited by 1,030 publications

(275 citation statements)

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“…The ratio of the Zr (IV) and CHPC in the complex is determined by Job's method of continues variation 10 as modified by Vosburgh and cooper 11 by taking their equimolar solution (5.5×10 -4 M) according the procedure mentioned above. The ratio of Zr(IV)and CHPC is further confirmed by mole ratio method 12 using equimolar solution of Zr(IV) and CHPC(5.5×10 -4 M).…”

Section: Stoichiometry Of the Extracted Speciesmentioning

confidence: 99%

Extractive spectrophotometric determination of Zirconium with 6-chloro-3-hydroxy-2-phenyl-4H-chromen-4-one as an analytical reagent

2017

JCBSC

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Section: Stoichiometry Of the Extracted Speciesmentioning

confidence: 99%

Extractive spectrophotometric determination of Zirconium with 6-chloro-3-hydroxy-2-phenyl-4H-chromen-4-one as an analytical reagent

2017

JCBSC

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“…In order to establish molar ratio between Ethambutol and dyestuffs used, the Job's method 28 of continuous variation has been applied. In this method, solutions of drug and dyestuff with identical molar concentrations (8 x 10 -5 M) were mixed in varying volume ratios in such a way that the total volume of each mixture was the same.…”

Section: Stoichiometrymentioning

confidence: 99%

Untitled

2016

IJPSR

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Simple and sensitive extractive spectrophotometric methods for the determination of Ethambutol in pure form and in pharmaceutical formulations using triphenyl methane dyes have been developed. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with triphenyl methane dyes viz., bromocresol green (BCG), bromocresol purple (BCP) and bromophenol blue (BPB) in acidic medium. The extracted complexes formed with BCG, BCP and BPB showed absorbance maxima at 420, 419 and 415 nm respectively. The stoichiometry of the ion-pair complex is found to be 1:1 in each case. Beer's law is obeyed in the concentration ranges 2.0-25, 3.0-30 and 4.0-40 μg/ml with BCG, BCP and BPB respectively. The effect of concentration of dye, pH, and interference of excipients have been studied for optimization. The limits of detection and quantification have been determined for all the three methods. These methods have been validated as per the guidelines of ICH. The results of analysis were validated statistically through recovery studies.

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“…The chelation abilities of 8-11 towards bio-metal cations such as Fe þ3 , Fe þ2 , Cu þ2 and Zn þ2 were investigated by Job's method 18,19 based on the changes in the UV-Vis absorption spectra due to the complex formation. The results of complexation studies are summarized in Table 2 and indicate that all compounds are able to form metal complex with Fe þ3 , Fe þ2 and Cu þ2 ( Figures S1-S12 Supplementary material).…”

Section: Chemistrymentioning

confidence: 99%

Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors

Friggeri¹,

Vita²,

Pandolfi³

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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Metal ions, especially copper, zinc and iron, play an important role in the neurodegeneration process because they can affect protein misfolding, leading to the formation of the amyloid deposits and oxidative stress leading to reactive oxygen species (ROS). Here we report the synthesis and evaluation as antioxidant and metal chelating agents of 3,4-dihydroxybenzoic acid derivatives. Synthesized compounds were tested by the 2,2-diphenyl-2-picrylhydrazyl (DPPH) method showing a radical scavenging ability (EC 50 ¼ 0.093-0.118 mM) higher than Trolox used as reference. Furthermore, these compounds were able to bind both iron and copper, especially the iron (III), by the formation of hexa-coordinated complexes. Synthesized compounds were tested to evaluate their ability to inhibit acetyl-and butyryl-cholinesterase; the obtained results have demonstrated that they are selective inhibitors of AChE (K i ¼ 1.5-18.9 mM) and result weakly active versus butyrylcholinesterase (BChE).

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Complex Ions. I. The Identification of Complex Ions in Solution by Spectrophotometric Measurements

Abstract: A method for the identification of compounds formed in solutions by reaction of two components has been described by Job.3 The method is applicable to complex ions. The formation of many complex ions can be represented by the equation A + hB AB" (I)

Cited by 1,030 publications

References 0 publications

Extractive spectrophotometric determination of Zirconium with 6-chloro-3-hydroxy-2-phenyl-4H-chromen-4-one as an analytical reagent

Extractive spectrophotometric determination of Zirconium with 6-chloro-3-hydroxy-2-phenyl-4H-chromen-4-one as an analytical reagent

Untitled

Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors

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