Abstract:Acute Promyelocytic leukemia (APL) is characterized by t(15;17) translocation. A subset of APL patients may have additional chromosomal abnormalities, the clinical significance of which remains controversial. Here we present a case of APL with complex karyotype including t(1;9)(q12;q12) for the first time who died during treatment because of coagulopathy and we emphasize the need of large multicenter collaborative trials to establish prognostic significance of additional cytogenetic abnormalities (ACA) in APL … Show more
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