Complex Mixture-Associated Hormesis and Toxicity: The Case of Leather Tanning Industry

Pagano, Giovanni; Castello, Giuseppe; Gallo, M.; Borriello, I.; Guida, Marco

doi:10.2203/dose-response.08-013.pagano

Cited by 8 publications

(5 citation statements)

References 41 publications

(64 reference statements)

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“…3 However, most of these reports have focused on individual chemicals, and mixtures represent the prevailing form of environmentally occurring contaminants such as in wastewaters, combustion exhausts, and industrial sludge. 4 Only a few studies have been devoted to hormetic effects of mixtures of municipal solid waste landfill leachates, 5 polychlorinated biphenyls (PCBs), 6 four metals (As, Cd, Cr, and Pb), 7 and persistent organic pollutants (POPs). 8 Important questions are (i) Can the size and concentration range of the hormetic stimulation be predicted in mixtures of compounds?…”

Section: ' Introductionmentioning

confidence: 99%

“…In recent decades, a growing body of evidence has accumulated on hormetic effects of several chemicals for a number of biological end points of cellular systems and organisms . However, most of these reports have focused on individual chemicals, and mixtures represent the prevailing form of environmentally occurring contaminants such as in wastewaters, combustion exhausts, and industrial sludge . Only a few studies have been devoted to hormetic effects of mixtures of municipal solid waste landfill leachates, polychlorinated biphenyls (PCBs), four metals (As, Cd, Cr, and Pb), and persistent organic pollutants (POPs) …”

Section: Introductionmentioning

confidence: 99%

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Predicting Hormetic Effects of Ionic Liquid Mixtures on Luciferase Activity Using the Concentration Addition Model

Liu

Zhu

et al. 2010

Environ. Sci. Technol.

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The concept of hormesis has generated considerable interest within the environmental and toxicological communities over the past decades. However, toxicological evaluation and prediction of hormesis in mixtures are challenging and only just unfolding. The hormetic effects of ten ionic liquids (ILs), singly and in mixtures in the ratios of their individual EC50, EC10, EC0, and ECm (maximal stimulatory effect concentration), on luciferase luminescence were determined by using microplate toxicity analysis. There was good agreement between the effects observed and predicted by concentration addition (CA) for all four mixtures. This evidence supports the use of CA model as a default approach for assessing the combined effect of chemicals at the molecular level. Focusing on the selected points of the concentration-response curves (CRCs) of mixtures, the mixtures of IL chemicals mixed at concentrations that individually showed stimulatory effects could produce inhibitory or no effects, and the mixture of IL chemicals mixed at concentrations that individually showed no effects could produce significant inhibitory effect. The three interesting phenomena in mixture hormesis may have important implications for current risk assessment practices.

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Section: ' Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predicting Hormetic Effects of Ionic Liquid Mixtures on Luciferase Activity Using the Concentration Addition Model

Liu

Zhu

et al. 2010

Environ. Sci. Technol.

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“…In the more specific fields of agriculture and zootechny, and in the use of REEs as ingredients for fertilizers and feed additives, a persuasive body of evidence reports advantages to using REEs for increasing crop yield and livestock performance. Indeed, as well-theorized by Edward Calabrese and his group [11][12][13]38], REEs display hormetic dose-response trends, just as with a number of other chemical and physical agents, which are being underpinned with increasingly sophisticated theoretical frameworks [71][72][73][74]. However, it should be noted that REEs are rarely present individually but usually more likely as a mixture of REEs.…”

Section: Toward Production Of Ree Mixtures As Hormetic Agentsmentioning

confidence: 97%

Evaluation of Rare Earth Element-Associated Hormetic Effects in Candidate Fertilizers and Livestock Feed Additives

Tommasi

Thomas

Lyons

et al. 2022

Biol Trace Elem Res

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Rare earth elements (REEs) are recognized as emerging contaminants with implications in human and environmental health. Apart from their adverse effects, REEs have been reported as having positive effects when amended to fertilizers and livestock feed additives, thus suggesting a hormetic trend, implying a concentration-related shift from stimulation to inhibition and toxicity, with analogous trends that have been assessed for a number of xenobiotics. In view of optimizing the success of REE mixtures in stimulating crop yield and/or livestock growth or egg production, one should foresee the comparative concentration-related effects of individual REEs (e.g., Ce and La) vs. their mixtures, which may display distinct trends. The results might prompt further explorations on the use of REE mixtures vs. single REEs aimed at optimizing the preparation of fertilizers and feed additives, in view of the potential recognition of their use in agronomy and zootechny.

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“…A lthough tannin exerts hormetic effects at low concentration (0.1-0.3 mg L -1 ) on sea urchin embryo, at higher concentration it has embryoto xic effects (De Nico la et al, 2004 and lowers the mitotic activity of the embryonic cells (Pagano, Castello, Gallo, Borriello, & Guida, 2008). Moreover, the egg envelope (chorion o r zona radiata) proteins are members of a unique group of structural proteins (Hyllner, Westerlund, Olsson, & Schopen, 2001;Arukwe & Goksøyr, 2003), which can be decomposed during the last stage of hatching by the hatching protease (chorionase) (Yamagami, 1973;Hagenmaier, 1974a,b;Luczynski, Strzczek, & Brzu zan, 1987) o r chorio lysins (Kawaguchi et al, 2013).…”

Section: +mentioning

confidence: 99%

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Ljubobratović¹,

Csengeri²,

Kucska³

et al. 2017

Turk. J. Fish. Aquat. Sci.

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The methods for removal of adhesiveness in pikeperch eggs were compared in this study . Following the hormonal induction with carp pituitary, eggs of three females were used in each of two trials. Firstly, three common methods were tested: tannic acid, enzyme and milk. Tannic acid treatment led to poor hatching (2.5±0.5%), significantly lower than the other treatments (75.5±19.3% and 72.3±28.8%, enzyme and milk, respectively). In order to find the source of negative outcome, in the second trial the influence of water hardness on the tannic acid bath was tested through three treatments with varying concentrations of disodium ethylenediaminetetraacetic acid salt (NA 2 EDTA). Softening of the tannic acid bath did not lead to improved hatching rates (5.5±1.3%, 3.5±1.5% and 2.7±1.3% for 0, 400 and 800 ppm of EDTA, respectively). Evaluation of the effects of tannin and EDTA on water chemistry revealed that the use of tannin can alter the embryonic development and hatching process. While de-adhesion procedure with milk appeared to be impractical, the application of tannic acid bath leads to variable and lower hatching outcomes. Thus, usage of enzymes was found to be the most promising method which should be further described for straightforward implementation in practice.

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Complex Mixture-Associated Hormesis and Toxicity: The Case of Leather Tanning Industry

Cited by 8 publications

References 41 publications

Predicting Hormetic Effects of Ionic Liquid Mixtures on Luciferase Activity Using the Concentration Addition Model

Predicting Hormetic Effects of Ionic Liquid Mixtures on Luciferase Activity Using the Concentration Addition Model

Evaluation of Rare Earth Element-Associated Hormetic Effects in Candidate Fertilizers and Livestock Feed Additives

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