Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats

Yamamoto, Hideo; Schmidt‐Kastner, Rainald; Hamasaki, D.I.; Yamamoto, Hiroko; Parel, Jean Marie

doi:10.1016/j.exer.2005.09.019

Cited by 65 publications

(59 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Permanent bilateral middle cerebral artery ligation in adult rats produced only subtle retinal changes (20). Bilateral common carotid occlusion induced damage in the GCL and INL at 1 wk and 2 mo, respectively, after injury in adult Wistar rats (13). Transient middle cerebral artery occlusion resulted in pyknotic cells in the GCL and INL 2 h after reperfusion.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the early microglial activation, we did not found prominent GFAP immuoreactivity until P21. However, very intense GFAP labeling was seen by 1 wk after retinal ischemia in adult rats (13). During retinal injury, Műller cells are well known to undergo reactive gliosis characterized by the upregulation of GFAP (19).…”

Section: Hypoxic-ischemic Retinal Injurymentioning

confidence: 99%

“…Several retinal ischemia models, including high intraocular pressure, vascular occlusion, and intravitreal injection of NMDA (N-methyl-D-aspartate), have been well established in adult rodents. A common hallmark for these conditions is the progressive degeneration and the final neuronal loss in the ganglion cell layer (GCL) (8)(9)(10)(11)(12)(13). However, it remains to be determined whether the developing eyes are vulnerable to HI damage at both pathological and functional levels.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Hypoxic–ischemic retinal injury in rat pups

Huang

Hung

et al. 2012

Pediatr Res

View full text Add to dashboard Cite

Background: Visual loss associated with brain damage, especially hypoxic-ischemic (hI) encephalopathy, is the most common cause of visual impairment in children in developed countries. We hypothesized that hI insults can cause long-term damage in immature eyes. Methods: In postnatal day 7 rat pups, hI was induced by unilateral common carotid artery ligation followed by hypoxia. Retina damage was assessed by electroretinography (eRG) and cell counting. Neuronal injury and astrogliosis were evaluated by terminal deoxynucleotidyl transferase nick-end labeling, cleaved caspase 3, eD1, and glial fibrillary acidic protein immunostaining. results: We observed rapid and persistently extensive injuries in the ganglia cell layer (GcL), inner plexiform layer, and inner nuclear layer (INL) in ipsilateral retinas after hI injury, corresponding to the marked alteration in eRG. hI insult caused prominent microglial and Műller cell activation in ipsilateral inner retinas. Neuronal death in the GcL and INL after hI injury was mainly apoptotic, involving caspase-dependent pathways. conclusion: Our study demonstrated the first evidence of hI retinal damage at both the pathological and functional level using the Vannucci model in neonatal rats. Because retinal damage is often associated with hI injury, it is important to demonstrate that a particular neuroprotective strategy effectively preserves the retina in addition to the brain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Hypoxic-ischemic Retinal Injurymentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Hypoxic–ischemic retinal injury in rat pups

Huang

Hung

et al. 2012

Pediatr Res

View full text Add to dashboard Cite

show abstract

“…This model reduces the cortical/hippocampal blood flow to 25-50% of the normal levels in 2.5 hours post occlusion (Yamamoto et al, 2006). The blood flow in the retina may be more severely reduced than in the brain.…”

Section: Chronic Carotid Ligationmentioning

confidence: 99%

Animal Models of Retinal Ischemia

Minhas¹,

Anand²

2011

Brain Injury - Pathogenesis, Monitoring, Recovery and Management

View full text Add to dashboard Cite

“…It also affects the retina and optic nerve, thus providing a useful model for investigating the mechanisms of neuron losses and therapy for degeneration associated with vascular defects 1,2 .…”

Section: Introductionmentioning

confidence: 99%

Learning and survival memory undergoing a permanent bilateral carotid ligation in rats

Melo¹,

Gadelha²,

Mascena³

et al. 2013

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL). METHODS:Twenty-four survivors of PBCL were evaluated after 30 days with regard to memory and learning using a water survival maze. Twenty-three healthy rats were used as control group. The results were expressed by their means and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee for animal investigation. RESULTS:The mortality rate for the surgery was 44.4%. The latency time to find the survival platform was higher in rats that underwent PBCL (Normal: 10.24 ± 1.85s -Study: 25.30 ± 4.69s -Mann-Whitney p=0.0388). Additionally, the type of swimming and the spatial stability of the studied rats on the survival platform were compromised in these animals. CONCLUSION:The permanent bilateral carotid ligation induces change in the learning and survival memory.

show abstract

Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats

Cited by 65 publications

References 37 publications

Hypoxic–ischemic retinal injury in rat pups

Hypoxic–ischemic retinal injury in rat pups

Animal Models of Retinal Ischemia

Learning and survival memory undergoing a permanent bilateral carotid ligation in rats

Contact Info

Product

Resources

About