Complex of (−)-Morphine with β-Phenylhydracrylic Acid

Codeine dihydrogen phosphate hemihydrate

“…They adopt the characteristic T conformation, which is known from related compounds of the opiate family, e.g. morphine monohydrate (Bye, 1976) and morphine derivatives, such as morphine monohydrate (Bye, 1976), salts (Mackay & Hodgkin, 1955;Gylbert, 1973;Wongweichintana et al, 1984;Lutz & Spek, 1998) and derivatives (e.g. Canfield et al, 1979;Deschamps et al, 1996;Gathergood et al, 2003;Balchin et al, 2004) of morphine, the free base form of codeine (Canfield et al, 1987), codeine monohydrate (Bel'skii et al, 1988), codeine hydrobromide dihydrate (Kartha et al, 1962) and codeine derivatives (Grant et al, 1993;Kolev et al, 2006;Liebman et al, 1978).…”

Morphine hydrochloride anhydrate

“…For related structures, see: Guguta et al (2008); Gylbert (1973); Mackay & Hodgkin (1955); Bye (1976); Wongweichintana et al (1984); Lutz & Spek (1998); Scheins et al (2005). For hysdrogen-bond motifs, see: Bernstein et al (1995); Etter et al (1990).…”

“…Morphine is the principal alkaloid of opium. Several crystal forms of the free base as well as salts have been investigated in previous studies: a monohydrate (Bye, 1976), a hydrochloride trihydrate (Gylbert, 1973), a hydroiodide dihydrate (Mackay & Hodgkin, 1955), a complex with β-phenylhydracrylic acid (Lutz & Spek, 1998) and a bis(morphininium) dihydrogensulfate pentahydrate (Wongweichintana et al, 1984). The crystal structure of the title salt was previously solved from powder data by Guguta et al (2008).…”

“…The Clion is additionally N-H•••Cl bonded to the protonation site of a second cation, which is related to the first cation by a 2 1 screw operation parallel to the b-axis. An infinite hydrogen-bonded chain is formed as a result of these interactions, and the chain structure propagates parallel to the b-axis (Figure 2a The program XPac (Gelbrich & Hursthouse, 2005) was used to compare the packing of the morphinium ions with that of the analogous moieties in the five related structures mentioned above (Bye, 1976;Gylbert, 1973;Mackay & Hodgkin, 1955;Lutz & Spek, 1998;Wongweichintana et al, 1984). In this group, the closest similarity relationship involving the title structure is based on a single stack of molecules ('one-dimensional supramolecular construct′, Figure 3) that is also present in the monohydrate (Bye, 1976).…”

Stable polymorph of morphine

“…For related structures, see: Guguta et al (2008); Gylbert (1973); Mackay & Hodgkin (1955); Bye (1976); Wongweichintana et al (1984); Lutz & Spek (1998); Scheins et al (2005); Gelbrich et al (2012). For decriptions of morphine polymorphs, see: Kofler (1933); Kuhnert-Brandstä tter et al (1975).…”