Complex poly(lactic acid)-based biomaterial for urinary catheters: II. Biocompatibility

Abstract

The present paper is focused on the surface and bulk characterization of poly(lactic acid) (PLA)-based composites that contain hydrolyzed collagen as a biological polymer, silver nanoparticles and vitamin E and epoxidized soybean oil as a plasticizer. The bionanocomposites were obtained by melt processing and evaluated for structural and surface characteristics, biocompatibility, functional properties such as antimicrobial and antioxidant activity and hydrolytic degradation behavior. It has been established that the optimal composition to impart functional properties to the PLA matrix is a formulation containing 15% epoxidized soybean oil, 15% hydrolyzed collagen, 5% Pluronic, 5% vitamin E and 0·3% silver nanoparticles. This bionanocomposite inhibits the growth of both Gram-positive bacteria, Escherichia coli and Salmonella typhimurium, and Gram-negative bacteria, Listeria monocytogenes, and reaches 100% radical-scavenging activity. The PLA-based biomaterials obtained in this study are stable in biological media in the short and medium terms and therefore are recommended as multifunctional biomaterials for the manufacture of medical devices, such as urinary catheters.

Complex poly(lactic acid)-based biomaterial for urinary catheters: I. Influence of AgNP on properties

“…60 The average surface composition of two samples given in Table 6 is close to the experimental one. 60 determined from DSC and differential thermal analysis (DTA) curves ( Figure 9 and Table 7).…”

“…The multifunctionality and biocompatibility characteristics are evidenced by the results given in the second part of this research work. 60 Your contribution will be forwarded to the author(s) for a reply and, if considered appropriate by the editorin-chief, will be published as a discussion in a future issue of the journal.…”

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials

“…[ 83 ] have shown that cell (fibroblast) spreading appeared to be dependent on the polar surface free energy. Cell spreading is low when the SFE’s polar part of the material is lower than 5 mN/m, and marked spreading occurs when is higher than 15 mN/m [ 43 ]. Based on the values of the SFE polar part determined for the PLA/R composites, it can be assumed that the sample incorporating all the components (PLA/PEG/0.5R) will give better spreading and division of the fibroblasts because their takes an intermediary value.…”

“…For more details on the method see references [ 38 , 39 ]. To determine the surface free energy (SFE) components, the CA at equilibrium between the film surface and three pure liquids (in addition to water, methylene iodide, and formamide were used, as-purchased at maximum obtainable purity) were measured by fitting the drop profile using the Young-Laplace equation [ 40 , 41 , 42 , 43 ]. The acid/base (LW/AB) approach of van Oss and Good, see Equation (4) [ 44 , 45 ], was used to calculate the total SFE and its components, namely the dispersive component, also named the Lifshitz–van der Waals interaction, ( ) and polar Lewis acid-base interactions ( ), respectively, see Equation (5).…”

Biocompatible Materials Based on Plasticized Poly(lactic acid), Chitosan and Rosemary Ethanolic Extract I. Effect of Chitosan on the Properties of Plasticized Poly(lactic acid) Materials

“…For more details on the method, see references [81,82]. To obtain the components of the surface free energy (SFE) and the total SFE of the polymer films, the CA at equilibrium between the film surface and three pure liquid, twice-distilled water, formamide and methylene iodide (as purchased at maximum obtainable purity), was measured by fitting the drop profile using the Young-Laplace equation [82,83,84,85]. The total and the components of SFE were calculated by using the Lifshitz-van der Waals acid/base approach of van Oss and Good [86], which divides the total SFE into dispersive Lifshitz-van der Waals interactions (γsvLW) and polar Lewis acid-base interactions (γsvAB) (Equation (8)).…”