Complex Portal - A Unifying Protein Complex Database

Meldal, Birgit; Combe, Colin; Bye-A-Jee, Hema; Heimbach, Joshua; Koch, Maximilian; Sullivan, Julie; Yehudi, Yo; Micklem, Gos; Hermjakob, Henning; Millán, Pablo Porras; Orchard, Sandra

doi:10.18547/gcb.2018.vol4.iss1.e100052

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…The Complex Portal is an encyclopaedic resource of macromolecular complexes derived from molecular interaction evidences extracted from the literature [7].…”

Section: Contributed Talks and Ccb 2017 Special Issuementioning

confidence: 99%

Protein Interaction Networks and Disease: Highlights of the 3rd Challenges in Computational Biology Meeting

Alanis-Lobato

Petrakis

2017

Genomics Comput Biol

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Cellular functions are managed by a complex network of protein interactions, the malfunction of which may derive in disease phenotypes.In spite of the incompleteness and noise present in our current protein interaction maps, computational biologists are making strenuous efforts to extract knowledge from these intricate networks and, through their integration with other types of biological data, expedite the development of novel and more effective treatments against human disorders.The 3rd Challenges in Computational Biology meeting revolved around the Protein Interaction Networks and Disease subject, bringing expert network biologists to the city of Mainz, Germany to debate the current status and limitations of protein interaction data and computational resources. This editorial outlines the meeting's background and programme, putting special emphasis on the extended abstracts of contributed talks collected in the present issue of Genomics and Computational Biology.

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“…The Complex Portal is an encyclopaedic resource of macromolecular complexes derived from molecular interaction evidences extracted from the literature [7].…”

Section: Contributed Talks and Ccb 2017 Special Issuementioning

confidence: 99%

Protein Interaction Networks and Disease: Highlights of the 3rd Challenges in Computational Biology Meeting

Alanis-Lobato

Petrakis

2017

Genomics Comput Biol

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A Review of Pathway Databases and Related Methods Analysis

Ghulam

Lei

Guo

et al. 2020

CBIO

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: Pathway analysis integrates most of the computational tools for the investigation of high-level and complex human diseases. In the field of bioinformatics research, biological pathways analysis is an important part of systems biology. The molecular complexities of biological pathways are difficult to understand in human diseases, which can be explored through pathway analysis. In this review, we describe essential information related to pathway databases and their mechanisms, algorithms and methods. In the pathway database analysis, we present a brief introduction on how to gain knowledge from fundamental pathway data in regard to specific human pathways and how to use pathway databases and pathway analysis to predict diseases during an experiment. We also provide detailed information related to computational tools that are used in complex pathway data analysis, the roles of these tools in the bioinformatics field and how to store the pathway data. We illustrate various methodological difficulties that are faced during pathway analysis. The main ideas and techniques for the pathway-based examination approaches are presented. We provide the list of pathway databases and analytical tools. This review will serve as a helpful manual for pathway analysis databases.

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Complex Portal - A Unifying Protein Complex Database

Cited by 2 publications

References 3 publications

Protein Interaction Networks and Disease: Highlights of the 3rd Challenges in Computational Biology Meeting

Protein Interaction Networks and Disease: Highlights of the 3rd Challenges in Computational Biology Meeting

A Review of Pathway Databases and Related Methods Analysis

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