Complex regional pain syndrome in children: incidence and clinical characteristics

Abu-Arafeh, Hashem; Abu‐Arafeh, Ishaq

doi:10.1136/archdischild-2015-310233

Cited by 40 publications

(45 citation statements)

References 28 publications

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“…Pediatric CRPS I occurs frequently in girls, around the age of 12 or 13 years, after minor injuries of lower limbs with a predisposition for the foot and ankle. 2 , 5 – 7 , 12 , 13 Symptoms include severe pain disproportionate to the inciting injury, allodynia, hyperpathia, edema, occasionally paralysis and occasionally involuntary movements as in the adult CRPS I. Psychological or familial backgrounds are associated with the development of pediatric CRPS I.…”

Section: Discussionmentioning

confidence: 99%

“…NSAIDs and pregabalin reduce hyperactivity of primary nociceptive fibers peripherally and centrally. NSAIDs 27 and pregabalin 7 , 30 have been administered to children with CRPS I.…”

Section: Discussionmentioning

confidence: 99%

“…4 – 6 Early and prompt diagnosis of CRPS I leads to a quicker and more favorable outcome in children. 2 , 4 , 6 However, pediatric CRPS I can be accompanied by serious disruptions to family and school life 5 , 7 , 8 and occasionally leads to subsequent psychosocial problems. 8 Pediatric CRPS I has several notable features: it is prevalent in girls around the age of 12 and occurs in the lower limbs 2 , 5 , 6 with a tendency to occur after ankle sprain.…”

Section: Introductionmentioning

confidence: 99%

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Recovery from acute pediatric complex regional pain syndrome type I after ankle sprain by early pharmacological and physical therapies in primary care: a case report

Takahashi

Tominaga

Okawa

et al. 2018

JPR

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BackgroundComplex regional pain syndrome type I (CRPS I) in children is a serious condition disrupting the family and school life of patients with the condition after it fully develops. It has been emphasized that early diagnosis is closely associated with earlier reduction of pain leading to preferable outcomes.ObjectivesTo report a case of acute CRPS I in a boy who was found to develop this condition by a routine visual analog scale (VAS) pain monitoring and who recovered from CRPS I at an early phase by prompt pharmacological, physical, and educational therapies.Study designCase report.Case reportA 12-year-old boy sprained his left ankle while playing soccer and was referred to our clinic 4 days after the injury. At the first visit, he could walk, reporting motion pain with a VAS scale of 80 mm. On day 5, pain intensity increased to 100 mm, and a diagnosis of acute CRPS I was made. On day 7, he could not move the injured ankle; therefore celecoxib and pregabalin were administered, and physical and educational therapies started. On day 35, pain intensity was 0 mm and he could walk and run normally.ConclusionRoutine monitoring of VAS for every patient in pain is useful to discover an abnormal transition of VAS, enabling the early diagnosis of CRPS I. Inflammation and peripheral or central sensitization are postulated for early development of CRPS I. The present case suggested a combination of physical therapy and pharmacological intervention with celecoxib and pregabalin reduced peripheral and central sensitization.

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Section: Discussionmentioning

confidence: 99%

“…NSAIDs and pregabalin reduce hyperactivity of primary nociceptive fibers peripherally and centrally. NSAIDs 27 and pregabalin 7 , 30 have been administered to children with CRPS I.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recovery from acute pediatric complex regional pain syndrome type I after ankle sprain by early pharmacological and physical therapies in primary care: a case report

Takahashi

Tominaga

Okawa

et al. 2018

JPR

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“…Its general incidence in children is reported to be around 1.2/100,000 children 5 to 15 years old, and it occurs much more often in females (73-85%). 2,3 The purpose of this report is to emphasize the possibility, against earlier thoughts, that well-indicated surgery in pediatric CRPS patients may lead to symptom improvement and may not be uniformly predicted to fail. We present an interesting case, which highlights not only the development of a CRPS in the presence of unrecognized skeletal damage but also most importantly its prompt resolution after surgical treatment despite the ongoing CRPS.…”

Section: Introductionmentioning

confidence: 95%

Severe Pediatric Wrist Joint Sequelae following Blunt Trauma in the Presence of Chronic Regional Pain Syndrome

Abualruz

Farr

2020

Journal of Hand and Microsurgery

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Introduction The pediatric chronic regional pain syndrome (CRPS) type I is a recognized syndrome that follows a preliminary event (e.g., trauma, fracture) with amplified spontaneous or stimuli-induced extremity pain that differs from its adult form with rather favorable outcomes. Conservative treatment is usually indicated for CRPS treatment. Case Description We present a unique case of an adolescent girl who revealed severe wrist joint sequelae following a blunt trauma, complicated by a challenging CRPS resistant to treatment. Diagnostic wrist arthroscopy eventually revealed a massive cartilage degeneration and scapholunate tear as underlying causes for the pain and CRPS. It was decided to proceed with radioscapholunate wrist fusion, which promptly led to pain relief and disappearance of the CRPS. Conclusion The relevance of this report is therefore to emphasize the possibility, against earlier thoughts, that well-indicated surgeries in pediatric CRPS patients may lead to prompt symptom improvement and may not be uniformly predicted to fail. With the clinical probability of a presence of an uncontrolled, symptomatic causative factor such as cartilage degeneration and chondrolysis, further early diagnostic and therapeutic interventions may be indicated to control the disease.

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“…59 Substantial reassuring vaccine safety data have been accumulated from pre-licensure trials as well as postlicensure monitoring and evaluations. 60 Syncope and anaphylaxis are known, 61 The biological mechanisms of CRPS and POTS are not well understood. CRPS is a rare chronic pain disorder that affects one part of the body and is disproportionate to the intensity of any injury or tissue damage.…”

Section: Hpv Vaccine and Pots And Crpsmentioning

confidence: 99%

Novel vaccine safety issues and areas that would benefit from further research

et al. 2021

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Vaccine licensure requires a very high safety standard and vaccines routinely used are very safe. Vaccine safety monitoring prelicensure and postlicensure enables continual assessment to ensure the benefits outweigh the risks and, when safety problems arise, they are quickly identified, characterised and further problems prevented when possible. We review five vaccine safety case studies: (1) dengue vaccine and enhanced dengue disease, (2) pandemic influenza vaccine and narcolepsy, (3) rotavirus vaccine and intussusception, (4) human papillomavirus vaccine and postural orthostatic tachycardia syndrome and complex regional pain syndrome, and (5) RTS,S/adjuvant system 01 malaria vaccine and meningitis, cerebral malaria, female mortality and rebound severe malaria. These case studies were selected because they are recent and varied in the vaccine safety challenges they elucidate. Bringing these case studies together, we develop lessons learned that can be useful for addressing some of the potential safety issues that will inevitably arise with new vaccines.

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Complex regional pain syndrome in children: incidence and clinical characteristics

Abstract: The estimated incidence of CRPS is 1.2/100 000 children 5-15 years old. The diagnosis of CRPS is often delayed. CRPS has a significant impact on children and their families.

Cited by 40 publications

References 28 publications

Recovery from acute pediatric complex regional pain syndrome type I after ankle sprain by early pharmacological and physical therapies in primary care: a case report

Recovery from acute pediatric complex regional pain syndrome type I after ankle sprain by early pharmacological and physical therapies in primary care: a case report

Severe Pediatric Wrist Joint Sequelae following Blunt Trauma in the Presence of Chronic Regional Pain Syndrome

Novel vaccine safety issues and areas that would benefit from further research

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