“…These events are characterized by vasodilatation, increase permeability, leucocyte migration and swelling tissue (Schmid-Schönbein 2006, Ahmed 2011 with generation of mediators known as histamine, bradykinin, serotonin, prostaglandins, derivatives molecules from the GLAUCIEMAR DEL- VECHIO-VIEIRA et al complement system, and lymphokines (Ahmed 2011). In addition, pathologic disorders, as cardiovascular and metabolic complications, peptic ulcer, cancer and others, are related to the oxidative processes, pain and inflammation (Alie et al 2014, Klöting and Blüher 2014, Ganty and Chawla 2014, Sen et al 2010. However, the nonsteroidal antiinflammatory drugs, for example, promote adverse effects, such as irritation of gastric mucosa and ulcer, water retention and nephrotoxicity, compromising the use of these therapeutic agents (Teslim et al 2014, Slater et al 2010.…”