Complex repetitive behavior: Punding after bilateral subthalamic nucleus stimulation in Parkinson's disease

Pallanti, Stefano; Bernardi, Silvia; Raglione, Laura Maria; Marini, P.; Ammannati, Franco; Sorbi, Sandro; Ramat, Silvia

doi:10.1016/j.parkreldis.2010.02.011

Cited by 19 publications

(12 citation statements)

References 24 publications

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“…In addition, following DERM-SAP treatment, roughly 30% of mu opioid receptor-labeled patches remained intact, which could explain why there was not a complete abolishment of stereotypy following repeated COC treatment and challenge. It is also possible that extrastriatal regions such as the pedunculopontine nucleus or subthalamic nucleus may also contribute to psychostimulant-induced stereotypic behavior (Aliane et al, 2012; Barwick et al, 2000; Inglis et al, 1994; Mathur et al, 1997; Pallanti et al, 2010). Nevertheless, despite these potential limitations, these are among the data first to specifically examine the role of the patch compartment in the development of stereotypic behaviors following repeated COC treatment and challenge.…”

Section: Discussionmentioning

confidence: 99%

Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration

2015

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Stereotypy can be characterized as inflexible, repetitive behaviors that occur following repeated exposure to psychostimulants, such as cocaine (COC). Stereotypy may be related to preferential activation of the patch (striosome) compartment of striatum, as enhanced relative activation of the patch compartment has been shown to positively correlate with the emergence of stereotypy following repeated psychostimulant treatment. However, the specific contribution of the patch compartment to COC-induced stereotypy following repeated exposure is unknown. To elucidate the involvement of the patch compartment to the development of stereotypy following repeated COC exposure, we determined if destruction of this sub-region altered COC-induced behaviors. The neurons of the patch compartment were ablated by bilateral infusion of the neurotoxin dermorphin-saporin (DERM-SAP; 17 ng/μl) into the striatum. Animals were allowed to recover for eight days following the infusion, and then were given daily injections of COC (25 mg/kg) or saline for one week, followed by a weeklong drug-free period. Animals were then given a challenge dose of saline or COC, observed for 2h in activity chambers and sacrificed. The number of mu-labeled patches in the striatum were reduced by DERM-SAP pretreatment. In COC-treated animals DERM-SAP pretreatment significantly reduced the immobilization and intensity of stereotypy but increased locomotor activity. DERM-SAP pretreatment attenuated COC-induced c-Fos expression in the patch compartment, while enhancing COC-induced c-Fos expression in the matrix compartment. These data indicate that the patch compartment contributes to repetitive behavior and suggests that alterations in activity in the patch vs matrix compartments may underlie to this phenomenon.

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Section: Discussionmentioning

confidence: 99%

Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration

2015

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“…It is also important to keep in mind that following DERM-SAP treatment, roughly 30% of mu opioid receptor-labeled patches remained intact, which could explain why we failed to see a complete abolishment of METH-induced stereotypy. Furthermore, the fact that a certain degree of METH-induced stereotypy remained following perturbation of the patch compartment points to a potential contribution of extrastriatal regions such as the pedunculopontine nucleus or subthalamic nucleus to psychostimulant-induced stereotypic behavior (Aliane et al ., 2012, Barwick et al ., 2000, Inglis et al ., 1994, Mathur et al ., 1997, Pallanti et al ., 2010). In addition, since our techniques involved one-dimensional analyses of patch density and utilized mean density of mu opioid receptor immunohistochemical staining rather than quantifying cell counts to determine the degree of patch destruction, it is possible that we were not able to fully detect the effects of DERM-SAP treatment on the patch compartment.…”

Section: Discussionmentioning

confidence: 99%

Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex

et al. 2013

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Methamphetamine (METH) induces stereotypy, which is characterized as inflexible, repetitive behavior. Enhanced activation of the patch compartment of the striatum has been correlated with stereotypy, suggesting that stereotypy may be related to preferential activation of this region. However, the specific contribution of the patch compartment to METH-induced stereotypy is not clear. In order to elucidate the involvement of the patch compartment to the development of METH-induced stereotypy, we determined if destruction of this sub-region altered METH-induced behaviors. Animals were bilaterally infused in the striatum with the neurotoxin dermorphinsaporin (DERM-SAP; 17 ng/μl) to specifically ablate the neurons of the patch compartment. Eight days later, animals were treated with METH (7.5 mg/kg), placed in activity chambers, observed for 2h and sacrificed. DERM-SAP pretreatment significantly reduced the number and total area of mu-labeled patches in the striatum. DERM-SAP pretreatment significantly reduced the intensity of METH-induced stereotypy and the spatial immobility typically observed with METH-induced stereotypy. In support of this observation, DERM-SAP pretreatment also significantly increased locomotor activity in METH-treated animals. In the striatum, DERM-SAP pretreatment attenuated METH-induced c-Fos expression in the patch compartment, while enhancing METH-induced cFos expression in the matrix compartment. DERM-SAP pretreatment followed by METH administration augmented c-Fos expression in the SNpc and reduced METH-induced c-Fos expression in the SNpr. In the medial prefrontal, but not sensorimotor cortex, c-Fos and zif/268 expression was increased following METH treatment in animals pre-treated with DERM-SAP. These data indicate that the patch compartment is necessary for the expression of repetitive behaviors and suggests that alterations in activity in the basal ganglia may contribute to this phenomenon.

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“…Several studies found a high prevalence of OCS and OCD also in Parkinson’s disease, but some others did not (Maia et al, 2003; Harbishettara et al, 2005). Furthermore, Pallanti et al (2010) described the onset of a complex repetitive behavior (defined as “pounding”) after bilateral subthalamic nucleus stimulation in Parkinson’s patients. Pounding has been interpreted as a compulsive behavior and is defined as a stereotypic motor behavior characterized by an intense fascination with repetitive purposeless movements, such as taking a part mechanical objects, handling common objects as if they were new and entertaining and continuously picking at oneself, etc.…”

Section: Methodsmentioning

confidence: 99%

Obsessive–Compulsive Disorder Comorbidity: Clinical Assessment and Therapeutic Implications

Pallanti¹,

Grassi²,

Sarrecchia³

et al. 2011

Front. Psychiatry

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112

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Obsessive–compulsive disorder (OCD) is a neuropsychiatric disorder affecting approximately 1–3% of the population. OCD is probably an etiologically heterogeneous condition. Individuals with OCD frequently have additional psychiatric disorders concomitantly or at some time during their lifetime. Recently, some authors proposed an OCD sub-classification based on comorbidity. An important issue in assessing comorbidity is the fact that the non-response to treatment often involves the presence of comorbid conditions. Non-responsive patients are more likely to meet criteria for comorbid axis I or axis II disorders and the presence of a specific comorbid condition could be a distinguishing feature in OCD, with influence on the treatment adequacy and outcome.

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Complex repetitive behavior: Punding after bilateral subthalamic nucleus stimulation in Parkinson's disease

Cited by 19 publications

References 24 publications

Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration

Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration

Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex

Obsessive–Compulsive Disorder Comorbidity: Clinical Assessment and Therapeutic Implications

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