Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications

Amara, Suneetha; Yang, Li V.; Tiriveedhi, Venkataswarup; Muzaffar, Mahvish

doi:10.3390/cells11121900

Cited by 4 publications

(1 citation statement)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous human research studies reported a possible link between the oral microbiota and carcinogenesis in different organs, including the gastrointestinal tract, the head and neck, the oral cavity, and the pancreas [7][8][9][10][11]. In line with these findings, a positive association of a higher diversity of microbiota with Haemophilus, Porphyromonas, Leptotrichia, and Fusobacteria compared to healthy adults with pancreatic cancer has been observed in large cohort human studies [12,13]. Additionally, investigations into Lactobacillus and Streptococcus genera (oral bacteria) have shown that they generate volatile sulfur compounds, short-chain fatty acids (SCFAs), reactive oxygen species, reactive nitrogen species, hydrogen peroxide, and lactic acid, all of which are implicated in carcinogenesis, chronic inflammation, genomic instability, tumor angiogenesis, and GC progression [14].…”

Section: Introductionsupporting

confidence: 68%

Exploring Connections between Oral Microbiota, Short-Chain Fatty Acids, and Specific Cancer Types: A Study of Oral Cancer, Head and Neck Cancer, Pancreatic Cancer, and Gastric Cancer

Nouri,

Choi,

Choi

et al. 2023

Cancers

View full text Add to dashboard Cite

The association between oral microbiota and cancer development has been a topic of intense research in recent years, with compelling evidence suggesting that the oral microbiome may play a significant role in cancer initiation and progression. However, the causal connections between the two remain a subject of debate, and the underlying mechanisms are not fully understood. In this case–control study, we aimed to identify common oral microbiota associated with several cancer types and investigate the potential mechanisms that may trigger immune responses and initiate cancer upon cytokine secretion. Saliva and blood samples were collected from 309 adult cancer patients and 745 healthy controls to analyze the oral microbiome and the mechanisms involved in cancer initiation. Machine learning techniques revealed that six bacterial genera were associated with cancer. The abundance of Leuconostoc, Streptococcus, Abiotrophia, and Prevotella was reduced in the cancer group, while abundance of Haemophilus and Neisseria enhanced. G protein-coupled receptor kinase, H+-transporting ATPase, and futalosine hydrolase were found significantly enriched in the cancer group. Total short-chain fatty acid (SCFAs) concentrations and free fatty acid receptor 2 (FFAR2) expression levels were greater in the control group when compared with the cancer group, while serum tumor necrosis factor alpha induced protein 8 (TNFAIP8), interleukin-6 (IL6), and signal transducer and activator of transcription 3 (STAT3) levels were higher in the cancer group when compared with the control group. These results suggested that the alterations in the composition of oral microbiota can contribute to a reduction in SCFAs and FFAR2 expression that may initiate an inflammatory response through the upregulation of TNFAIP8 and the IL-6/STAT3 pathway, which could ultimately increase the risk of cancer onset.

show abstract

Section: Introductionsupporting

confidence: 68%

Exploring Connections between Oral Microbiota, Short-Chain Fatty Acids, and Specific Cancer Types: A Study of Oral Cancer, Head and Neck Cancer, Pancreatic Cancer, and Gastric Cancer

Nouri,

Choi,

Choi

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer

Bi,

Wang,

Liu

2024

Biomolecules

View full text Add to dashboard Cite

Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores the interplay between intratumoral microbiota, tumor metabolism, and major types of GI cancers (including esophageal, gastric, liver, pancreatic, and colorectal cancers), summarizing recent studies and elucidating their clinical implications and future directions. Recent research revealed altered microbial signatures within GI tumors, impacting tumor progression, immune responses, and treatment outcomes. Dysbiosis-induced alterations in tumor metabolism, including glycolysis, fatty acid metabolism, and amino acid metabolism, play critical roles in cancer progression and therapeutic resistance. The integration of molecular mechanisms and potential biomarkers into this understanding further enhances the prognostic significance of intratumoral microbiota composition and therapeutic opportunities targeting microbiota-mediated tumor metabolism. Despite advancements, challenges remain in understanding the dynamic interactions within the tumor microenvironment (TME). Future research directions, including advanced omics technologies and prospective clinical studies, offer promising avenues for precision oncology and personalized treatment interventions in GI cancer. Overall, integrating microbiota-based approaches and molecular biomarkers into GI cancer management holds promise for improving patient outcomes and survival.

show abstract

Pancreatic Cancer Resistance to Treatment: The Role of Microbiota

et al. 2023

View full text Add to dashboard Cite

Pancreatic cancer (PC) is an aggressive malignancy and the fourth leading cause of cancer death in the United States and Europe. It is estimated that PC will be the second leading cause of cancer death by 2030. In addition to late diagnosis, treatment resistance is a major cause of shortened survival in pancreatic cancer. In this context, there is growing evidence that microbes play a regulatory role, particularly in therapy resistance and in creating a microenvironment in the tumor, that favors cancer progression. The presence of certain bacteria belonging to the gamma-proteobacteria or mycoplasmas appears to be associated with both pharmacokinetic and pharmacodynamic changes. Recent evidence suggests that the microbiota may also play a role in resistance mechanisms to immunotherapy and radiotherapy. However, the interactions between microbiota and therapy are bilateral and modulate therapy tolerance. Future perspectives are increasingly focused on elucidating the role of the microbiota in tumorigenesis and processes of therapy resistance, and a better understanding of these mechanisms may provide important opportunities to improve survival in these patients.

show abstract

Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications

Cited by 4 publications

References 109 publications

Exploring Connections between Oral Microbiota, Short-Chain Fatty Acids, and Specific Cancer Types: A Study of Oral Cancer, Head and Neck Cancer, Pancreatic Cancer, and Gastric Cancer

Exploring Connections between Oral Microbiota, Short-Chain Fatty Acids, and Specific Cancer Types: A Study of Oral Cancer, Head and Neck Cancer, Pancreatic Cancer, and Gastric Cancer

Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer

Pancreatic Cancer Resistance to Treatment: The Role of Microbiota

Contact Info

Product

Resources

About