Complex tibial fracture outcomes following treatment with low-intensity pulsed ultrasound

Leung, Kwok‐Sui; Lee, Wing‐Sze; Tsui, Hi Yi; Liu, Paul Po-Lung; Cheung, Wing-Hoi

doi:10.1016/j.ultrasmedbio.2003.11.008

Cited by 173 publications

(133 citation statements)

References 20 publications

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“…Between the methods available to enhance musculoskeletal disorders healing, US has suggested as a safe, practical, and effective treatment. [22,28,34,35] In our opinion, extensive clinical and experimental and long-term studies investigating biophysical mechanisms of LIPUS are required.…”

Section: Resultsmentioning

confidence: 99%

“…LIPUS produces the pressure waves, which in duce biochemical and molecular events at the cellular level and whereby accelerated healing of osteoporosis. [22,[28][29][30][31][32] The results of biomechanical and histologic investigations prove that LIPUS have effects on bone mineral density and mechanical strength. They also concluded that LIPUS stimulates bone formation in distraction osteogenesis and acceleration of healing or strength.…”

Section: Lipus and Osteoporosismentioning

confidence: 92%

“…Others have shown that LIPUS treatment increases the degree of vascularity, indication that US increases blood flow. [22,23] This study reviewed the mechanism of US stimulation in osteoporosis treatment.…”

Section: Review Articlementioning

confidence: 99%

“…The finding suggested that LIPUS therapy, if scaled for whole body use, has clear clinical benefits for the treatment of osteoporosis. [22,[35][36][37] …”

Section: Lipus and Osteoporosismentioning

confidence: 99%

“…These results determined that LIPUS have a significant effect on the earlier inflammatory or accelerate to callus formation phases of healing. [22,31,[73][74][75] In a study with a rat femoral fracture model, hard callus area, bone mineral content, mechanical torsion properties were measured at 4 different periods (1-8 days, 9-16 days, 17-24 days, 1-24 days) after expose to LIPUS, along with histologic analysis. The findings reported statistically significant increases in all measured parameters in all groups when compared with the control group.…”

Section: Time-dependent Effectmentioning

confidence: 99%

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Rashidi

2017

AJP

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Ultrasound (US) waves due to their unique features can be a treatment option for osteoporosis. Initial studies have shown promising but controversial outcomes. Several preclinical and clinical studies have been conducted on osteoporosis and studies are ongoing to find optimum US parameters, mechanisms of action, and therapeutic efficacies of these techniques for osteoporosis treatment. This paper was aimed to review the recent advances of using US waves in the treatment of osteoporosis and possible mechanisms of actions. The databases of PubMed (1980PubMed ( -2016, EMBASE (1980EMBASE ( -2016, Web of Sciences (1980-2016), and Google Scholar (1980-2016 were searched using the set terms. The obtained records were reviewed, and relevant studies were selected for comprehensive review of the current literature. Low-intensity pulsed US (LIPUS) has biological effects on the bone healing process and it can accelerate bone regeneration. Current evidence is limited on the efficacy of US waves for treatment or prevention of osteoporosis; however, the initial studies are promising. The US waves can promote osteoblast and inhibit osteoclast, enhance angiogenesis, trigger expression of different genes associated with osteogenesis. No definite dose-response existed on the clinical trials of US wave applications. The current evidence shows the therapeutic efficacy of US waves particularly LIPUS for osteoporosis treatment; however, to observe therapeutic outcomes long-term US stimulation is required. No definitive dose-response is proposed for osteoporosis. Further in vitro and clinical trials should be conducted to develop US-based techniques for the treatment of osteoporosis as a clinical treatment option.

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Section: Resultsmentioning

confidence: 99%

Section: Lipus and Osteoporosismentioning

confidence: 92%

Section: Review Articlementioning

confidence: 99%

“…The finding suggested that LIPUS therapy, if scaled for whole body use, has clear clinical benefits for the treatment of osteoporosis. [22,[35][36][37] …”

Section: Lipus and Osteoporosismentioning

confidence: 99%