Complex transposition with interrupted right aortic arch and partial Di George syndrome: Successful palliation with combined medical and surgical therapy

Duncan, W. Jack; Tyrrell, Michael J.; Bharadwaj, B; Rosenberg, Alan; Schroêder, M.; Bingham, William

doi:10.1007/bf02427049

Cited by 5 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As it is known that some immunologic disorders are associated with congenital heart diseases and a lack of thymic shadow on X-ray examination (Asherson and Webster 1980;Bockman and Kirby 1984;Duncan et al 1984), clinical and immunologic examinations were undertaken in this group of children.…”

Section: Introductionmentioning

confidence: 99%

Immunologic defects as possible causes of therapeutic failures in children with transposition of the great arteries

Marek-Szydłowska¹,

Szydłowski

Uracz³

et al. 1987

Z Rechtsmed

View full text Add to dashboard Cite

Recurrent and severe infections and absence of thymic shadow in X-ray examination were observed in children with the transposition of the great arteries (TGA). Among 45 children (29 boys and 16 girls) with TGA whose age ranged from 3 days to 16 years and who were hospitalized during 1 year, infectious diarrhea was observed in 77.7% cases, urinary tract infections in 44.5%, respiratory tract infections in 42.2%, sepsis in 17.5%, and meningitis in 8.8%. Nine of the children died, sepsis was a cause of death in seven children, and there were postsurgical complications in two children. Immunologic abnormalities in children with TGA included a decreased level of T-lymphocytes and T29 degrees subpopulation, impaired mitogen-induced lymphoproliferation in vitro, and increased nitro blue tetrazolium (NBT) reduction activity of monocytes. Impaired parameters of cellular immunity correlated with worst clinical status. No disorders of humoral immunity were observed. These observations may be important for forming opinion about proper therapy and the cause of death in children with TGA.

show abstract

Section: Introductionmentioning

confidence: 99%