Complexation behavior of gelatin with amphiphilic drug imipramine hydrochloride as studied by conductimetry, surface tensiometry and circular dichroism studies

Carbon Nanotube Reinforced Hybrid Microgels as Scaffold Materials for Cell Encapsulation

“…Moreover, the spectrum of the signal obtained from the GelMA coated CNTs had lower peak amplitude observed at 198nm. In a previous study, a random coil peptide upon interacting with nanoparticles had a change in the secondary structure which was observed by the decrease in the negative peak at 198nm 29 , which is similar to our observations. It was reported that proteins have the ability to strongly bind onto CNT surface due to the hydrophobic interaction.…”

“…To characterize the structure of GelMA on the surface of CNTs, circular dichroism (CD) was conducted to analyze the polypeptide backbone conformations. The strong negative peak at 198 nm shown in Figure e indicates that GelMA adopted a typical gelatin conformation similar to a random coil structure . As gelatin is derived by breaking the triple-helix structure of collagen, the amplitude of the positive peak at 220 nm, characteristic of the triple-helix, had almost disappeared.…”

“…The strong negative peak at 198 nm shown in Figure 1(e) indicates that GelMA adopted a typical gelatin conformation similar to a random coil structure. 29 As gelatin is derived by breaking the triple-helix structure of collagen, the amplitude of the positive peak at 220 nm, characteristic of the triple-helix, had almost disappeared. However, GelMA showed a decrease in the amplitude of the negative peak at 198nm when compared to gelatin, which may be caused by the methacrylated pendant groups on its polypeptide backbone (degree of methacrylation: 75%).…”

Effect of hydroxychloroquine sulfate on the gelation behavior, water mobility and structure of gelatin

“…The physical and chemical properties of gelatin, especially its crosslinking density, degradation kinetics, and gel properties, provide many possibilities for designing drug delivery carriers. Therefore, their (either alone or in support of any other polymer) application in the field of medicine is attracting increasing attention [9] , [10] , [11] . At present, research on the use of gelatin in the field of medicine is primarily focused on the encapsulation and targeted delivery of compounds, such as anticancer and miscellaneous drugs, proteins, and vaccines to improve the in vivo degradation kinetic parameters, improve therapeutic effects, and reduce toxicity and side effects [12] , [13] , [14] , [15] , [16] .…”

Polymer-Amphiphile Interactions: An Overview

“…A variety of drug molecules, such as antihistamines, antidepressants, tranquilizers, local anesthetics, and nonsteroidal anti-inflammatory drugs (NSAIDs) are known to be amphiphilic in nature and form ordinary micelles or micelle-like associations above the cmc [43][44][45][46][47]. These drugs may interact with polymers in surfactant-like manner, i.e., there may exist cac, cmc or psp (polymer saturation point) [48]. The cac, the start of aggregation, is either near or well below the cmc of pure amphiphile [49] while the cmc is assigned to saturation of polymer domains by the monomers and/or micelle-like aggregates [24,[50][51][52][53].…”