Complexation of Al(III) with reduced glutathione in acidic aqueous solutions

Wang, Xianlong; Li, Kun; Yang, Xiao Di; Wang, Ling Ling; Shen, Ren Fang

doi:10.1016/j.jinorgbio.2008.11.007

Cited by 45 publications

(25 citation statements)

References 52 publications

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“…Different experimental techniques have been devoted to investigate the metal complexes of GSH, such as electron paramagnetic resonance (EPR) [26,27], NMR [28,29], X-ray diffraction (X-ray) [30,31] and ESI-MS [32]. Nevertheless, it is difficult to explain the structures of the complexes at the atomic and electronic level.…”

Section: Introductionmentioning

confidence: 99%

Probing the coordination properties of glutathione with transition metal ions (Cr2+,Mn2+,Fe2+,Co2+, Ni2+,Cu2+,Zn2+,Cd2+,Hg2+) by density functional theory

Liu

et al. 2014

J Biol Phys

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Probing the coordination properties of glutathione with transition metal ions (Cr 2+,were larger than that of M-N and M-O; for Cr 2+ complexes, most of the WBIs of M-O in complexes were higher than that of M-S and M-N. Furthermore, the changes in the electron configuration of the metal cations before and after chelate reaction revealed that Cu 2+ , Ni 2+ , Co 2+ and Hg 2+ had obvious tendencies to be reduced to Cu + , Ni + , Co + and Hg + during the coordination process.

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Section: Introductionmentioning

confidence: 99%

Probing the coordination properties of glutathione with transition metal ions (Cr2+,Mn2+,Fe2+,Co2+, Ni2+,Cu2+,Zn2+,Cd2+,Hg2+) by density functional theory

Liu

et al. 2014

J Biol Phys

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“…Successively, to our knowledge only few papers, published from 2007 to present time, reported new protonation constant values for this ligand (Ferretti et al 2007;Leverrier et al 2007;Enyedy et al 2008;Yang et al 2008;Wang et al 2009). Most of these new data were obtained in KCl (aq) or in buffer solutions, and will not be discussed in detail here, since protonation constants in this medium were the subject of another contribution (Crea et al 2007).…”

Section: Literature Comparisonsmentioning

confidence: 96%

“…Nevertheless, it is important to underline here that all the main properties of glutathione and its derivatives are strictly dependent on their chemical behavior in aqueous solution, since biological fluids, natural and waste waters, and soil solutions are ''aqueous media''. Above all, the acid-base properties affect both (1) the binding ability of glutathione toward several metal cations and other ligands (e.g., (Noszal and Szakacs 2003;Dorcak and Krezel 2003;Wang et al 2009;Mah and Jalilehvand 2008)) and (2) its redox behavior (e.g., (Madej and Wardman 2007;Gough and Lees 2005)). This is one of the main reasons that induced us to undertake a systematic study on the dependence on medium and ionic strength of glutathione acidbase behavior.…”

Section: Introductionmentioning

confidence: 99%

Modeling the acid–base properties of glutathione in different ionic media, with particular reference to natural waters and biological fluids

et al. 2011

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The acid-base properties of γ-L-glutamyl-L-cysteinyl-glycine (glutathione, GSH) were determined by potentiometry (ISE-H(+), glass electrode) in pure NaI((aq)) and in NaCl((aq))/MgCl(2(aq)), and NaCl((aq))/CaCl(2(aq)) mixtures, at T = 298.15 K and different ionic strengths (up to I(c) ~ 5.0 mol L(-1)). In addition, the activity coefficients of glutathione were also determined by the distribution method at the same temperature in various ionic media (LiCl((aq)), NaCl((aq)), KCl((aq)), CsCl((aq)), MgCl(2(aq)), CaCl(2(aq)), NaI((aq))). The results obtained were also used to calculate the Specific ion Interaction Theory (SIT) and Pitzer coefficients for the dependence on medium and ionic strength of glutathione species, as well as the formation constants of weak Mg(j)H( i )(GSH)((i+2j-3)) and Ca(j)H(i)(GSH)((i+2j-3)) complexes. Direct calorimetric titrations were also carried out in pure NaCl((aq)) and in NaCl((aq))/CaCl(2(aq)) mixtures at different ionic strengths (0.25 ≤ I (c )/mol L(-1) ≤ 5.0) in order to determine the enthalpy changes for the protonation and complex formation equilibria in these media at T = 298.15 K. Results obtained are useful for the definition of glutathione speciation in any aqueous media containing the main cations of natural waters and biological fluids, such as Na(+), K(+), Mg(2+), and Ca(2+). Finally, this kind of systematic studies, where a series of ionic media (e.g., all alkali metal chlorides) is taken into account in the determination of various thermodynamic parameters, is useful for the definition of some trends in the thermodynamic behavior of glutathione in aqueous solution.

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“…Several studies [27][28][29] indicate a characteristic shielding at 0.000 ppm for hexa-coordinated aluminum. Therefore, peaks in the region of 0.000 ppm suggest octahedral arrangements.…”

Section: C Nmrmentioning

confidence: 99%

Multinuclear magnetic resonance study of equilibria between aluminum(III) and sulfur-containing amino acids in aqueous solutions

Tenório

2015

Journal of Sulfur Chemistry

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Aluminum(III) is generally found in small amounts in living organisms where it interacts with several biomolecules. Low mass biomolecules can form complexes associated with absorption and distribution processes of this toxic ion. However, investigating aluminum(III) complexes in solution poses singular difficulties, because it is highly hydrolyzable. Amino acids constitute possible ligands for aluminum(III). Methionine, cysteine and homocysteine are found in healthy human body. Penicillamine is a drug used in several circumstances, such as in treating metal poisoning. These four biomolecules share similar donor atoms involved in complexation reactions: a carboxylate oxygen, an amine nitrogen and sulfur. In this study, four binary complexes formed by aluminum(III) and amino acids in solution at a metalto-ligand ratio of 1:1 were analyzed through potentiometry and multinuclear magnetic resonance ( 13 C and 27 Al). Potentiometry data consistently demonstrated complexion formation. Distributions of species revealed the coexistence of several species in ample pH ranges and pointed out the preferable value to perform the NMR analyses. 13 C NMR data were used to confirm complexion formation, while 27 Al NMR data indicated the geometric arrangement adopted by the complexes. Structures were proposed for each complex.• Amino acids can form complexes related to the absorption and distribution of Al 3+ .• The techniques used were potentiometry, 13 C NMR and 27 Al NMR in solution.• The potentiometry reveals distribution of species according to pH of binary systems.• The 13 C NMR results indicate complexion formation.• The 27 Al NMR results indicate hexa-coordinated aluminum in the complex species.

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Complexation of Al(III) with reduced glutathione in acidic aqueous solutions

Cited by 45 publications

References 52 publications

Probing the coordination properties of glutathione with transition metal ions (Cr2+,Mn2+,Fe2+,Co2+, Ni2+,Cu2+,Zn2+,Cd2+,Hg2+) by density functional theory

Probing the coordination properties of glutathione with transition metal ions (Cr2+,Mn2+,Fe2+,Co2+, Ni2+,Cu2+,Zn2+,Cd2+,Hg2+) by density functional theory

Modeling the acid–base properties of glutathione in different ionic media, with particular reference to natural waters and biological fluids

Multinuclear magnetic resonance study of equilibria between aluminum(III) and sulfur-containing amino acids in aqueous solutions

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