Complexation of Amino‐Acid‐Based Block Copolymers With Dual Thermoresponsive Properties and Water‐Soluble Silsesquioxane Nanoparticles

Abstract

Smart organic-inorganic hybrids are prepared using non-covalent interactions between watersoluble silsesquioxane nanoparticles and two amino acid-based block copolymers prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. A block copolymer displaying lower critical solution temperature (LCST) and upper critical solution temperature (UCST) is employed, in which only poly( N -acryloyl-4-trans -hydroxy-L -proline) segment could interact with the nanoparticles, whereas another poly( Nacryloyl-L -proline methyl ester) segment shows a thermoresponsive property without any interaction. The complexation of another type of dual thermosensitive block copolymer with two different LCSTs and the silsesquioxane nanoparticles is also investigated.

Amino‐Acid‐Based Block Copolymers by RAFT Polymerization

“…In addition, the size, shape, and nature of the inorganic nanoparticles and specific interactions between the organic and inorganic components act as crucial elements to provide an effective route for the controlled self‐ordering of nanoparticles with polymers and for the endowment of characteristic properties. Smart organic–inorganic hybrids were prepared using noncovalent interactions between water‐soluble silsesquioxane nanoparticles containing tertiary amine moieties and two amino‐acid‐based block copolymers prepared by RAFT polymerization (Scheme ) 203. A dual thermoresponsive block copolymer displaying LCST and UCST was employed, in which only the poly(A‐Hyp‐OH) segment could interact with the silsesquioxane nanoparticles, whereas another poly(A‐Pro‐OMe) segment showed a characteristic thermoresponsive property without any interaction with the nanoparticles.…”

pH responsive polymers with amino acids in the side chains and their potential applications

“…Straightforward mixing of aqueous solutions of P(A‐Hyp‐OH) and the silsesquioxane nanoparticles led to formation of pH responsive hybrids [Scheme (a)]. Furthermore, thermoresponsive properties and transition temperatures of the hybrids were manipulated by the selective complexation via non‐covalent interactions between water‐soluble silsesquioxane nanoparticles and amino acid‐based block copolymers [Scheme (b)] …”

Design and Synthesis of Functional Silsesquioxane-Based Hybrids by Hydrolytic Condensation of Bulky Triethoxysilanes

“…Additionally, the size, shape, and nature of the inorganic nanoparticles and specific interactions between the organic and inorganic components act as crucial elements to provide an effective route for the controlled self-ordering of nanoparticles with polymers and for the endowment of characteristic properties. Smart organic-inorganic hybrids were prepared using noncovalent interactions between watersoluble silsesquioxane nanoparticles containing tertiary amine moieties and two amino acid-based block copolymers prepared by RAFT polymerization (Figure 11(b)) [121]. A dual thermoresponsive block copolymer displaying LCST and UCST was employed, in which only the poly(A-Hyp-OH) segment could interact with the silsesquioxane nanoparticles, whereas another poly(A-Pro-OMe) segment showed a characteristic thermoresponsive property without any interaction with the nanoparticles.…”