Complexation of iron by siderophores a review of their solution and structural chemistry and biological function

Raymond, Kenneth N.; Ga, Müller; Matzanke, Berthold F.

doi:10.1007/3-540-13099-3_2

Cited by 393 publications

(280 citation statements)

References 182 publications

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“…6.3, Table 1). The dissociation of ferrichrome was faster than that of ferrioxamine E under both conditions, which is consistent with the higher affinity of ferrioxamine E for iron [Raymond et al, 1984]. The k d values obtained in seawater are in good agreement with previously published values from Witter et al, 2000 (shown in Table 1), which used electrochemical methods to monitor the competitive ligand exchange rate between 1-nitroso-2-naphthol (1N2N) and iron bound to individual siderophores in seawater.…”

Section: Fe Exchange For Model Compounds Under Marine Conditionssupporting

confidence: 90%

Molecular determination of marine iron ligands by mass spectrometry

Boiteau¹

2016

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Abstract:Marine microbes produce a wide variety of metal binding organic ligands that regulate the solubility and availability of biologically important metals such as iron, copper, cobalt, and zinc.In marine environments where the availability of iron limits microbial growth and carbon fixation rates, the ability to access organically bound iron confers a competitive advantage. Thus, the compounds that microbes produced to acquire iron play an important role in biogeochemical carbon and metal cycling. However, the source, abundance, and identity of these compounds are poorly understood. To investigate these processes, sensitive methodologies were developed to gain a compound-specific window into marine iron speciation by combining trace metal clean sample collection and chromatography with inductively coupled plasma mass spectrometry (LC-ICPMS) and electrospray ionization mass spectrometry (LC-ESIMS). Coupled with isotope pattern assisted search algorithms, these tools provide a means to quantify and isolate specific iron binding ligands from seawater and marine cultures, identify them based on their mass and fragmentation spectra, and investigate their metal binding kinetics.Using these techniques, we investigated the distribution and diversity of marine iron binding ligands. In cultures, LC-ICPMS-ESIMS was used to identify new members of siderophore classes produced by marine cyanobacteria and heterotrophic bacteria, including synechobactins and marinobactins. Applications to natural seawater samples from the Pacific Ocean revealed a wide diversity of both known and novel metal compounds that are linked to specific nutrient regimes. Ferrioxamines B, E, and G were identified in productive coastal waters near California and Peru, in oligotrophic waters of the North and South Pacific Gyre, and in association with zooplankton grazers. Siderophore concentrations were up to five-fold higher in iron-deficient offshore waters (9pM) and were dominated by amphibactins, amphiphilic siderophores that partition into cell membranes. Furthermore, synechobactins were detected within nepheloid layers along the continental shelf. These siderophores reflect adaptations that impact dissolved iron bioavailability and thus have important consequences for marine ecosystem community structures and primary productivity. The ability to map and characterize these compounds has opened new opportunities to better understand mechanisms that link metals with the microbes that use them. 4Acknowledgements:

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Section: Fe Exchange For Model Compounds Under Marine Conditionssupporting

confidence: 90%

Molecular determination of marine iron ligands by mass spectrometry

Boiteau¹

2016

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“…[38] Microbial siderophores usually exhibit high stability constants and their Fe complexes are reduced at low potentials. [39] Because of these properties, some results concluded that microbial siderophores are unlikely to be reduced by the reductase system on plant roots. [40] Plants and microorganisms can compete for iron under certain conditions, although the extent to which this influences plant ecology in nature can be questioned.…”

Section: Role Of Bacteria In the Rhizosphere Of Peanut Intercropped Wmentioning

confidence: 99%

Iron Nutrition of Peanut Enhanced by Mixed Cropping with Maize: Possible Role of Root Morphology and Rhizosphere Microflora

Zuo

Liao

Cao

et al. 2003

Journal of Plant Nutrition

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“…The externally-formed Fe^^ chelates may subsequently be taken up into the cell (Raymond, Muller & Matzanke, 1984;Adjimani & Fmery, 1987). In several fungi, the excretion of such iron-binding molecules is markedly stimulated by Fe deficiency and such compounds may also bind Ga (Adjimani & Fmergy, 1987).…”

Section: Extracellular Precipitation and Complexationmentioning

confidence: 99%

Interactions of fungi with toxic metals

1993

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SUMMARY This review details the major interactions of fungi with toxic metal species. Physico‐chemical and biological aspects are discussed including definitions and classification of metals in biological contexts, mechanisms of metal fungitoxicity, resistance and tolerance, environmental influences and the occurrence of fungi in metal‐polluted habitats. Cellular interactions include extracellular precipitation and complexation, binding to cell walls, transport of monovalent and divalent metal cations, intracellular fates of toxic metal species (including metal‐binding proteins and peptides, and vacuolar compartmentation), and metal transformations including organometal(loid) synthesis. Significant interactions between metals and mycorrhizal fungi and macrofungi are summarized with reference to the amelioration of plant phytotoxicity and metal accumulation respectively. Biotechnological aspects of metal‐fungal interactions relate to the biological treatment of metal‐contaminated effluents and waste streams for metal removal/recovery and environmental protection.

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Complexation of iron by siderophores a review of their solution and structural chemistry and biological function

Cited by 393 publications

References 182 publications

Molecular determination of marine iron ligands by mass spectrometry

Molecular determination of marine iron ligands by mass spectrometry

Iron Nutrition of Peanut Enhanced by Mixed Cropping with Maize: Possible Role of Root Morphology and Rhizosphere Microflora

Interactions of fungi with toxic metals

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