Complexes of Aluminum, Gallium and Indium With Pyrone Derivatives

Oxido- and mixed-ligand peroxido complexes of niobium(v) as potent phosphatase inhibitors and efficient catalysts for eco-friendly styrene epoxidation

“…67,78 Such downfield shifts are common in the case of many of the reported maltolato complexes. 51,67,[78][79][80] Similar downfield shifts of the H-5 and H-6 proton signals were also observed in the 1 H NMR spectrum of the deferiprone bonded pNb complex as anticipated…”

“…With an inherent ability to form both σ and π bonds with metal ions, these hydroxypyrone and hydroxypyridone ligands with nearly similar chelating abilities have been known to form stable metal complexes with significant biorelevant characteristics like charge neutrality, hydrolytic stability, lipophilicity and water solubility. [50][51][52][53] In addition to being widely known as a clinically important Fe chelator, deferiprone acts as an effective ligand to a range of metals, including Ga, Al, Zn, Cu, and especially Fe. 54,55 Maltol and deferiprone complexes of V(III) such as V(malt) 3 and V(def ) 3 •12H 2 O were reported to display significant anti-proliferation activity towards different cancer cells as well as insulin enhancing ability.…”

Lanthanide containing compounds for therapeutic care in bone resorption disorders

“…Caco-2 cells, originally derived from a human colorectal carcinoma line, differentiate at confluency into highly functional epithelial barriers with morphological and biochemical similarities to the smallintestinal columnar epithelium. 42-44, 49 These cells have been used to evaluate the relative bioavailability and transport mechanisms of diverse drugs in vitro. [64][65][66][67][68] When grown as a monolayer on a semipermeable membrane, the passage of drugs across the Caco-2 cell barrier can be monitored by analyzing the concentration of the desired compounds transported to either the basolateral (B, bottom) side through the mimicked intestinal environment, or to the apical (A, top) side through secretory transport.…”