Complexes of glutathione with heavy metals as catalysts for oxidation

Abstract

Research was carried out to determine the activity of complexes of tripeptideglutathione with heavy metals in the oxidation of cyclohexene with tert-butylhydroperoxide in toluene at 80°C. All the complexes were prepared by the interaction of metal ions and glutathione at room temperature in aqueous solutions. Only the complexes of Mo were obtained from acidic aqueous solution. The characteristics of these complexes were determined by means of FTIR and Mössbauer spectroscopies and EPR analysis. The products of the epoxidation and hydroxylation reactions were identified using GC analysis. The complexes of molybdenum and vanadium showed higher activity in the epoxidation reaction of cyclohexene compared to the other complexes, namely of Mn, Co, Cu, Cr, Fe, Cd and Th. The possible structures of the complexes are offered. The possible use of glutathione complexes as catalysts in the model reaction of oxidation is newly demonstrated.

Water-Soluble Iron Oxide Nanoparticles with High Stability and Selective Surface Functionality

“…The IR band of −SH group at 2521 cm –1 disappeared for GSH-coated NPs due to the disulfide bond formation. Unfortunately, the IR band of the disulfide bonds (470 cm –1 ) is below the detection limit of our instrument. Along with the zeta-potential study, the FTIR spectrum further confirmed our hypothesis of the −NH 2 groups attached onto NP surfaces.…”

Impact of Glutathione on Wines Oxidative Stability: A Combined Sensory and Metabolomic Study

“…Glutathione (reduced form of glutathione, GSH) is an essential metabolite with multiple functions in plants, foods and beverages (Vermeulen et al, 2005 , 2006 ). Its roles include working as a source of reductant in many oxidation reactions, protecting against heavy metals toxicity, or lipids and polyphenols oxidation as ROS-scavenger (Dimitrova et al, 2010 ; Kreitman et al, 2013 ; Nimse and Pal, 2015 ). GSH is also reported being an important antioxidant, reacting as nucleophile substance that conjugates straightforwardly with reactive electrophiles resulting in foods and beverages chemical oxidative stability (Cilliers and Singleton, 1990 ; Nikolantonaki and Waterhouse, 2012 ; de Almeida et al, 2013 ; Nikolantonaki et al, 2014 ; Webber et al, 2014 ).…”

New Variations on the Theme of Gold(III) C∧N∧N Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization

“…This notwithstanding, well defined GSH metal complexes are still rare. [32][33][34] Thus, the new compounds were studied for spectroscopic properties, as well as for their antiproliferative effects in a small panel of human cancer cell lines and against nontumorigenic cells from embryonic kidney (HEK-293) in vitro. In order to characterize the compounds with biological nucleophiles, some of the most cytotoxic derivatives were studied for their reactivity with the model protein cytochrome c (cyt c) and mixtures of amino acids by Electrospray Ionization Mass Spectrometry (ESI MS).…”

“…However, studies also postulated the role of GSH adduct formation in the mechanisms of toxicity of cisplatin; thus, the design of metal–GSH complexes could be exploited as a strategy to increase the anticancer effects of experimental metallodrugs. This notwithstanding, well-defined GSH metal complexes are still rare. − …”