Complexes of lanthanide(III) nitrates with 10-(2-dimethylamino-1-methyl) phenothiazine

Keshavan, B.; Chandrashekara, P. G.

doi:10.1007/bf02872579

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Characteristic C=N stretching vibration for typical pyrazole compounds have been reported to absorb within this range. 24,27 Absorption of nitrate (NO3) group in the complexes appeared within 1185-1183 cm -1 which is in agreement with values obtained for coordinated nitrate group in a typical lanthanoid(III) complex. 28 The band at 1239 cm -1 is attributed to N-N of the pyrazole moiety which appeared less than the value (1391 cm -1 ) reported in literature.…”

Section: Infrared Spectral Data Of 5-((2-phenylacetoxy) Carbonyl)-1h-...supporting

confidence: 86%

Synthesis, Characterization, Antimicrobial and Antimalarial Activities of 5-((2- phenylacetoxy) carbonyl)-1H-pyrazole-3-carboxylic Acid and its Ce(III), Pr(III) and Nd(III) Complexes

2023

TJNPR

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In the current study, we report new 3,5-disubtitutedpyrazole derivativeswhich are nitrogen and oxygen containing compounds with antiplasmodial activity. Evidence from existing literature shows potential antiplasmodial activity of new compounds containing nitrogen and sulphur. 10 The compounds were synthesized and evaluated for their antiplasmodial activity. They were also screened for their in vitro antimalarial activity against chloroquine-resistant strain of P.falciparum. The compounds shows more potentactivity thanpositivecontroland exhibited reasonable in silico drug-likeness and pharmacokinetic properties. 12 Materials and Methods ReagentsAll reagents used were of analytical grade, only few were of reagent grade and they were all used without further purification.Phenylacetylchloride (98%), 3,5pyrazoledicarboxylic acid mono hydrate (97%), and the metal salts were products of Sigma Aldrich.Other reagents like chloroform (98%), ethanol (98%), and tetrahydro furan (THF) were obtained from Fluka. General Procedure for the Synthesis of 5-((2phenylacetoxy) carbonyl)-1H-pyrazole-3-carboxylic acid The ligand, 5-((2-phenylacetoxy) carbonyl)-1H-pyrazole-3-carboxylic acid was prepared by adopting methods reported in literature. 13,14 To equal mixture of chloroform and ethanol (50 mL), 2.612 g (5 mmol) of 3,5-Pyrazole dicarboxylic acid was added followed by 2.0 mL of phenylacetyl chloride under reflux for 2 h. The solution was left to stand for 2 weeks. A white crystal was obtained by filtration (Scheme 1). Synthesis of the ComplexesThe Ce(III), Pr(III) and Nd(III) complexes of the ligand were prepared according to the method described by Heinosuke (1967). 15 Generally, the ligand was reacted separately with the metal salts using mole ratio 2:1 under reflux for 2 h and the products formed were filtered and stored in the desiccator for further use.

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Section: Infrared Spectral Data Of 5-((2-phenylacetoxy) Carbonyl)-1h-...supporting

confidence: 86%

Synthesis, Characterization, Antimicrobial and Antimalarial Activities of 5-((2- phenylacetoxy) carbonyl)-1H-pyrazole-3-carboxylic Acid and its Ce(III), Pr(III) and Nd(III) Complexes

2023

TJNPR

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“…The absorption peaks at 517–518 and 427–453 cm −1 could be attributed to the stretching frequencies of ν (Bi–O) and ν (Bi–N), respectively 53–56 . Two complexes displayed four bands at 1492–1466, 1,353–1,333, 1,173–1,021, and 847–824 cm −1 , which could be attributed to the vibrational patterns of coordinated nitrate groups, further suggesting that the nitrate groups are attached to bismuth (III) ions in bidentate fashion 57–60 …”

Section: Resultsmentioning

confidence: 95%

“…[53][54][55][56] Two complexes displayed four bands at 1492-1466, 1,353-1,333, 1,173-1,021, and 847-824 cm À1 , which could be attributed to the vibrational patterns of coordinated nitrate groups, further suggesting that the nitrate groups are attached to bismuth (III) ions in bidentate fashion. [57][58][59][60]…”

Section: Ft-ir Analysismentioning

confidence: 99%

Synthesis, crystal structure, and in vitro biological evaluation of bismuth (III) complexes incorporating pyrazinohydrazide‐derived Schiff bases

Li,

Qiu,

et al. 2024

Applied Organom Chemis

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Two new Schiff‐base bismuth (III) complexes were prepared by an equivalent reaction between Schiff‐base ligand and Bi (NO3)3•5H2O with the assistance of Mannitol. The chemical structures of the two complexes were characterized by spectroscopic studies (FT‐IR, NMR, and MS), elemental analysis, and single‐crystal X‐ray diffraction. The ligand‐to‐metal ion ratio was found to be 1:1 in the complexes. During the formation of the complexes, Schiff bases changed from the amidic forms to the iminol forms, and the resulting tautomers could coordinate with bismuth (III) ions to produce dinuclear BiIII complexes(1a and 2a). Structural analyses showed that each Bi (III) ion held a distorted capped octahedron geometry with a seven‐coordinate mode in two complexes. Screening in vitro biological activities revealed that two bismuth (III) complexes exhibited much higher antimicrobial and cytotoxic activity than their parent ligands. The cytotoxic activity of the complex(1a) was close to that of the known anticancer drug (Doxorubicin) by evaluating against SGC7901 cells, with the IC50 value 0.59 μM. The complex(1a) could effectively induce SGC7901 cell apoptosis and its oral acute toxicity for LD50 value was found to be 576 mg kg−1. The content of bismuth (III) in mitochondria was higher than that in the nucleus.

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Synthesis, structure, preliminary antimicrobial and antimalarial studies of 1,1′-(piperazine-1,4-diyl)bis(2-phenylethan-1-one) and its lanthanide, Ce(III), Pr(III), and Nd(III) complexes

Adejoh,

Ukoha,

Hosten

et al. 2024

Journal of Molecular Structure

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Complexes of lanthanide(III) nitrates with 10-(2-dimethylamino-1-methyl) phenothiazine

Abstract: A new series of lanthanide(III) nitrate complexes with 10-(2dimethylamino-1-methyl) phenothiazine (isopromethazine) having the general formula [Ln(IP)2(NO3)2]NO3, where Ln

Cited by 3 publications

References 12 publications

Synthesis, Characterization, Antimicrobial and Antimalarial Activities of 5-((2- phenylacetoxy) carbonyl)-1H-pyrazole-3-carboxylic Acid and its Ce(III), Pr(III) and Nd(III) Complexes

Synthesis, Characterization, Antimicrobial and Antimalarial Activities of 5-((2- phenylacetoxy) carbonyl)-1H-pyrazole-3-carboxylic Acid and its Ce(III), Pr(III) and Nd(III) Complexes

Synthesis, crystal structure, and in vitro biological evaluation of bismuth (III) complexes incorporating pyrazinohydrazide‐derived Schiff bases

Synthesis, structure, preliminary antimicrobial and antimalarial studies of 1,1′-(piperazine-1,4-diyl)bis(2-phenylethan-1-one) and its lanthanide, Ce(III), Pr(III), and Nd(III) complexes

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