Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules − Mechanochemical Synthesis and Pharmacological Activity

Душкин, А. В.; Толстикова, Т. Г.; Хвостов, Михаил В.; Толстиков, Г. А.

doi:10.5772/48182

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Arabinogalactan (AG) is a natural branched polysaccharide with a molecular mass near 16 kDa extracted from Siberian larch [ 79 ]. AG is a highly water-soluble polymer which produces low-viscosity water solutions.…”

Section: Improvement Of Carotenoid Features By Supramolecular Deliver...mentioning

confidence: 99%

“…The solubility of carotenoids complexes with AG prepared by the mechanochemical technique [ 40 ] were 2–5 mM in aqueous solution, which is several orders of magnitude higher than the solubility of free carotenoids in pure water (~1 nM) [ 80 ]. The mechanochemical method allows the preparation of inclusion complexes of drugs with natural or synthetic polymers in a solid state in one technological step without using any organic solvents [ 79 ]. It was shown that complexation with AG prevents the H-aggregate formation of xanthophyll carotenoids in the presence of water, similarly to what was detected for GA complexes [ 17 ].…”

Section: Improvement Of Carotenoid Features By Supramolecular Deliver...mentioning

confidence: 99%

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The Endless World of Carotenoids—Structural, Chemical and Biological Aspects of Some Rare Carotenoids

Polyakov

Focsan

Gao

et al. 2023

IJMS

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Carotenoids are a large and diverse group of compounds that have been shown to have a wide range of potential health benefits. While some carotenoids have been extensively studied, many others have not received as much attention. Studying the physicochemical properties of carotenoids using electron paramagnetic resonance (EPR) and density functional theory (DFT) helped us understand their chemical structure and how they interact with other molecules in different environments. Ultimately, this can provide insights into their potential biological activity and how they might be used to promote health. In particular, some rare carotenoids, such as sioxanthin, siphonaxanthin and crocin, that are described here contain more functional groups than the conventional carotenoids, or have similar groups but with some situated outside of the rings, such as sapronaxanthin, myxol, deinoxanthin and sarcinaxanthin. By careful design or self-assembly, these rare carotenoids can form multiple H-bonds and coordination bonds in host molecules. The stability, oxidation potentials and antioxidant activity of the carotenoids can be improved in host molecules, and the photo-oxidation efficiency of the carotenoids can also be controlled. The photostability of the carotenoids can be increased if the carotenoids are embedded in a nonpolar environment when no bonds are formed. In addition, the application of nanosized supramolecular systems for carotenoid delivery can improve the stability and biological activity of rare carotenoids.

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Section: Improvement Of Carotenoid Features By Supramolecular Deliver...mentioning

confidence: 99%

Section: Improvement Of Carotenoid Features By Supramolecular Deliver...mentioning

confidence: 99%

The Endless World of Carotenoids—Structural, Chemical and Biological Aspects of Some Rare Carotenoids

Polyakov

Focsan

Gao

et al. 2023

IJMS

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“…Òåì íå ìåíåå èìåííî èõ ýêñòðàêòèâíîñòü îïðåäåëÿåò ôè-çèîëîãè÷åñêóþ àêòèâíîñòü ïðåïàðàòîâ ðàñòèòåëüíîãî ïðîèñõîaeäåíèÿ, ïðèìåíÿåìûõ ïåðîðàëüíî. Ðàíåå íà ïðèìåðå ìàëîðàñòâîðèìûõ ôàðìàöåâòè÷åñêèõ ñóáñòàíöèé (ÔÑ) ìû ïîêàçàëè âîçìîaeíîñòü ïîâûøåíèÿ èõ ðàñòâîðèìîñòè è ôàðìàêîëîãè÷åñêîé àêòèâíîñòè çà ñ÷åò îáðàçîâàíèÿ ìåaeìîëåêóëÿðíûõ/ñóïðàìîëåêóëÿðíûõ êîìïëåêñîâ ÔÑ ñ ïîëèñàõàðèäàìè è ðàñòèòåëüíûìè ãëèêîçèäàìè [16].…”

Section: àííîòàöèÿunclassified

Hypolipidemic Effect of the Phytocompositions of Gynostemma pentaphyllum and Polysaccharide Arabinogalactan Prepared by Means of Mechanochemistry

2015

KhUR

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Ãèíîñòåììà ïÿòèëèñòíàÿ (Gynostemma pentaphyllum) (ÃÏ) âèä òðàâÿíèñòûõ ðàñòåíèé èç ñåìåéñòâà òûêâåííûõ, ïðîèçðàñòàþùèõ â Âîñòî÷íîàçèàòñêî-òèõîîêåàíñêîì ðåãèîíå. Â òðàäèöèîííîé âîñòî÷íîé ìåäèöèíå ñ÷èòàåòñÿ, ÷òî íàïèòîê èç ëèñòüåâ ÃÏ ñïîñîáåí çàìåäëÿòü ñòàðåíèå, ïîâûøàòü èììóíèòåò è ðåãóëèðîâàòü êðîâÿíîå äàâëåíèå. Ðåçóëüòàòû íåäàâíèõ èññëåäîâàíèé ôàð-ìàêîëîãè÷åñêèõ ýôôåêòîâ ÃÏ ñâèäåòåëüñòâó-ÓÄÊ 615.322

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Effects of Three-time Administration of a Supramolecular Complex of Praziquantel with Disodium Glycyrrhizinate on Trematode Opisthorchis felineus in Hamsters

et al. 2021

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Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules − Mechanochemical Synthesis and Pharmacological Activity

Cited by 6 publications

References 35 publications

The Endless World of Carotenoids—Structural, Chemical and Biological Aspects of Some Rare Carotenoids

The Endless World of Carotenoids—Structural, Chemical and Biological Aspects of Some Rare Carotenoids

Hypolipidemic Effect of the Phytocompositions of Gynostemma pentaphyllum and Polysaccharide Arabinogalactan Prepared by Means of Mechanochemistry

Effects of Three-time Administration of a Supramolecular Complex of Praziquantel with Disodium Glycyrrhizinate on Trematode Opisthorchis felineus in Hamsters

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