Complexes of Zinc With Picolinic and Aspartic Acids Inactivate Free Varicella‐Zoster Virions

Shishkov, Stoyan; Varadinova, T.; Bontchev, P.R.; Nachev, C.; Michailova, Elena

doi:10.1155/mbd.1996.11

Cited by 13 publications

(14 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin C possesses a reversible concentration-dependent antiviral activity, and the continuous presence of ascorbic acid is needed to keep viruses suppressed ( 11 ) . Similarly, virus replication inhibited by Zn is concentration dependent and reversible in cell cultures ( 50 ) . In the past decade, immune cell activation by intracellular Ca signalling has been well known ( 51 ) .…”

Section: Discussionmentioning

confidence: 99%

Nutrient deficiencies as a risk factor in Taiwanese patients with postherpetic neuralgia

et al. 2011

View full text Add to dashboard Cite

Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). The aim of the present study was to compare the nutritional status of PHN patients with that of healthy controls, and then to identify risk factors for PHN using multivariate multiple logistic regressions. In the present cross-sectional study, we prospectively enrolled fifty PHN patients for at least 3 months and fifty healthy controls. We selected nine circulating nutrients including ionised Ca, Zn, retinol, folic acid, vitamin B 12 , vitamin C, a-tocopherol, g-tocopherol and lycopene associated with both immunity and the modulation of neuropathic pain, and measured their concentrations in plasma/serum. Concentrations of ionised Ca, Zn, vitamin C and vitamin B 12 were significantly lower in PHN patients than in controls after excluding those patients receiving supplements since the outbreak of HZ. The prevalence of either mild/marginal or severe deficiencies for any of the nine selected circulating nutrients in PHN patients (92 %) was much higher than that in controls (46 %) (P, 0·001). Lower concentrations of vitamin C (#45·0 mmol/l), ionised Ca (#1·05 mmol/l) and Zn (#0·91 g/l) were found to increase independently the risk of PHN using binary variable (dichotomy) analyses with both PHN patients and controls in a multivariate logistic regression analysis. No significant correlations existed between the risks of PHN and the concentrations of retinol, folic acid, vitamin B 12 , lycopene or a:g-tocopherol ratios. Thus, lower concentrations of circulating nutrients, namely vitamin C, ionised Ca or Zn, are probably a risk factor in Taiwanese patients with PHN.Key words: Nutritional status: Herpes zoster: Postherpetic neuralgia: Nutrient deficiencies: Risk factors Postherpetic neuralgia (PHN), a peripheral neuropathic pain syndrome, is the most common complication of herpes zoster (HZ) (1) . PHN can lead to long-term psychological distress, physical disability and tremendous use of health care resources (2) . Therefore, to identify risk factors for PHN and to effectively improve preventive strategies are clinically meaningful. Although old age, female sex, presence of a prodrome, greater acute pain severity, presence of severe rash (3) and immunocompromised patients (1) have been identified as independent predictors of PHN, discovering additional risk factors is still needed to prevent developing PHN with respect to HZ management (3) .An outbreak of HZ caused by a reactivation of latent varicella zoster virus (VZV) is primarily attributed to a reduction in host cellular immunity (1) . Additionally, two non-mutually exclusive theories of PHN are an alteration in the excitability of central neurons and a chronic active VZV ganglionitis caused by ongoing viral activity in patients developing PHN compared with HZ patients who do not (1,4) . Thus, reduced cellular immunity plays a critical factor in both zoster risk and the persistence of PHN (1,4) . Diminished cellular immunity has been advocated to be closely associated with def...

show abstract

Section: Discussionmentioning

confidence: 99%

Nutrient deficiencies as a risk factor in Taiwanese patients with postherpetic neuralgia

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Apart from HCMV mentioned above, the effect of zinc on other members of the Herpesviridae family remains unknown because of a lack of clinical data. Mechanistically, zinc ions have been shown to inhibit Varicella-Zoster virus by inactivating free virus in vitro ( 59 ). Both HSV and Varicella-Zoster virus belong to the Alphaherpesvirinae subfamily, reflecting their genetic relatedness, and similar mechanism of inhibition.…”

Section: Current Status Of Knowledgementioning

confidence: 99%

The Role of Zinc in Antiviral Immunity

Read

Obeid

Ahlenstiel

et al. 2019

Advances in Nutrition

633

602

View full text Add to dashboard Cite

Zinc is an essential trace element that is crucial for growth, development, and the maintenance of immune function. Its influence reaches all organs and cell types, representing an integral component of approximately 10% of the human proteome, and encompassing hundreds of key enzymes and transcription factors. Zinc deficiency is strikingly common, affecting up to a quarter of the population in developing countries, but also affecting distinct populations in the developed world as a result of lifestyle, age, and disease-mediated factors. Consequently, zinc status is a critical factor that can influence antiviral immunity, particularly as zinc-deficient populations are often most at risk of acquiring viral infections such as HIV or hepatitis C virus. This review summarizes current basic science and clinical evidence examining zinc as a direct antiviral, as well as a stimulant of antiviral immunity. An abundance of evidence has accumulated over the past 50 y to demonstrate the antiviral activity of zinc against a variety of viruses, and via numerous mechanisms. The therapeutic use of zinc for viral infections such as herpes simplex virus and the common cold has stemmed from these findings; however, there remains much to be learned regarding the antiviral mechanisms and clinical benefit of zinc supplementation as a preventative and therapeutic treatment for viral infections.

show abstract

“…Zn is known to exhibit a variety of direct and indirect antiviral properties. Previous literature has demonstrated that Zn homeostasis is interconnected with the emergence of infections related to coronaviridae [28] , picornavirus [29] , papilloma virus [30] , rhinovirus [31] , herpes simplex virus [32] , varicella-zoster virus [33] , respiratory syncytial virus (RSV) [34] , human immunodeficiency virus (HIV) [35] and hepatitis C virus (HCV) [36] . Interestingly, Zn displays antiviral properties by a number of physical processes, including virus attachment, penetration, infection, uncoating and replication [37] .…”

Section: The Molecular Basis Of Zinc (Zn) In Biological Systemsmentioning

confidence: 99%

“…Moreover, Zn may potentially inhibit direct membrane fusion of the semliki forest virus by binding to a particular histidine residue present on the viral protein E1 at low endosomal pH [40] . An in vitro study clearly demonstrated that Zn can directly inactivate the free varicella-zoster virus [33] . Zn salts facilitate viral destruction by abolishing viral entry, polyprotein processing, or viral RNA-dependent RNA polymerase (RdRP) activity in a number of other viruses, including SARS-CoV [28] , rhinovirus [31] , HSV [32] , HIV [35] and vaccinia virus [41] .…”

Section: The Molecular Basis Of Zinc (Zn) In Biological Systemsmentioning

confidence: 99%

Potential molecular mechanisms of zinc- and copper-mediated antiviral activity on COVID-19

et al. 2021

View full text Add to dashboard Cite

Novel coronavirus disease 2019 (COVID-19) has spread across the globe; and surprisingly, no potentially protective or therapeutic antiviral molecules are available to treat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, zinc (Zn) and copper (Cu) have been shown to exert protective effects due to their antioxidant, anti-inflammatory and antiviral properties. Therefore, it is hypothesized that supplementation with Zn and Cu alone or as an adjuvant may be beneficial with promising efficacy and a favorable safety profile to mitigate symptoms, as well as halt progression of the severe form of SARS-CoV-2 infection. The objective of this review is to discuss the proposed underlying molecular mechanisms and their implications for combating SARS-CoV-2 infection in response to Zn and Cu administration. Several clinical trials have also included the use of Zn as an adjuvant therapy with dietary regimens/antiviral drugs against COVID-19 infection. Overall, this review summarizes that nutritional intervention with Zn and Cu may offer an alternative treatment strategy by eliciting their virucidal effects through several fundamental molecular cascades, such as, modulation of immune responses, redox signaling, autophagy, and obstruction of viral entry and genome replication during SARS-CoV-2 infection.

show abstract

Complexes of Zinc With Picolinic and Aspartic Acids Inactivate Free Varicella‐Zoster Virions

Cited by 13 publications

References 6 publications

Nutrient deficiencies as a risk factor in Taiwanese patients with postherpetic neuralgia

Nutrient deficiencies as a risk factor in Taiwanese patients with postherpetic neuralgia

The Role of Zinc in Antiviral Immunity

Potential molecular mechanisms of zinc- and copper-mediated antiviral activity on COVID-19

Contact Info

Product

Resources

About