Complexes of Zn(II) and Сu(II) with the Amino Derivatives of Deoxycholic Acid: Syntheses, Structures, and Properties

Abstract

Complexes [Zn(L)Cl 2 ] (I), Cu(L)Cl 2 • H 2 O (II), Zn(L 1 )Cl 2 • 0.5H 2 O (III), and Cu(L 1 )Cl 2 • 0.5H 2 O (IV) (where L and L 1 are the diaminopropylene and diaminoethylene derivatives of deoxycholic acid, respectively) are synthesized. The structure of mononuclear complex I is determined by X-ray structure analysis (CIF file CCDC no. 1875305). The coordination polyhedron of the Zn atom (Cl 2 N 2 ) is a distorted tetrahedron. According to the X-ray diffraction data, the crystals of compounds III and IV are isostructural. It is shown by IR spectroscopy that the structures of complexes II-IV are similar to that of complex I. In the solid phase, compounds L and L 1 possess photoluminescence in the visible spectral range (λ max = 440 and 415 nm, respectively). Complex formation with Zn 2+ ions does not change the photoluminescence properties of L and L 1 .

A link between zinc uptake, bile salts, and a capsule required for virulence of a mastitis-associated extraintestinal pathogenicEscherichia colistrain

“…To our knowledge, there are no reports of bile salts specifically conferring zinc stress in other bacteria. However, the secondary bile acid deoxycholic acid can form organometallic complexes with zinc and other heavy metals which may make them unavailable for import, potentially affecting gene expression in many enteric bacteria [40–43]. E. coli O157:H7 is reported to increase expression of iron acquisition genes when exposed to bile, but repress key virulence genes including shiga toxin and the locus of enterocyte effacement [44].…”