Complexity in Differential Peptide–Receptor Signaling: Response to Segonzac et al. and Mueller et al. Commentaries

Lee, Horim; Khatri, Ashok; Plotnikov, Julia M.; Zhang, Xuecheng; Sheen, Jen

doi:10.1105/tpc.112.099259

Cited by 14 publications

(27 citation statements)

References 32 publications

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“…The interaction with RPK2 is not well characterized: single rpk2 and clv1 clv2 rpk2 triple mutant lines display phenotypes highly similar to clv3 mutants, suggesting a functional role for RPK2 in CLV3 perception and repressing WUS expression in the meristem (Kinoshita et al, 2010). Finally, CLV3 was reported to interact with the FLS2 receptor (Lee et al, 2011;H. Lee et al, 2012), which is known to recognize the unrelated bacterial flagellinderived peptide flg22 and activate plant innate immune responses (Gómez-Gómez and Boller, 2000).…”

Section: Sammentioning

confidence: 99%

“…Identifying peptide ligand-receptor (kinase) pairs will furthermore provide insight in the (distinct) roles of the numerous peptides in overlapping expression domains. However, the debate on the CLV3-FLS2 pair (Lee et al, 2011;H. Lee et al, 2012;Mueller et al, 2012aMueller et al, , 2012bSegonzac et al, 2012) illustrates the complexities of peptide signaling and the difficulties of working with these small peptides.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Small Signaling Peptides in Arabidopsis Development: How Cells Communicate Over a Short Distance

2012

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To sustain plants' postembryonic growth and development in a structure of cells fixed in cell walls, a tightly controlled short distance cell-cell communication is required. The focus on phytohormones, such as auxin, has historically overshadowed the importance of small peptide signals, but it is becoming clear that secreted peptide signals are important in cell-cell communication to coordinate and integrate cellular functions. However, of the more than 1000 potential secreted peptides, so far only very few have been functionally characterized or matched to a receptor. Here, we will describe our current knowledge on how small peptide signals can be identified, how they are modified and processed, which roles they play in Arabidopsis thaliana development, and through which receptors they act.

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Section: Sammentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Small Signaling Peptides in Arabidopsis Development: How Cells Communicate Over a Short Distance

2012

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“…Another key question is how CLV-WUS pathways integrate with abiotic or biotic stresses. Evidence for CLE crosstalk with defense receptor signaling is controversial, but it remains clear that stress leads to a general reduction in plant growth, and it will be interesting to see mechanistically how this affects CLV-WUS feedback (Lee et al, 2011(Lee et al, , 2012Mueller et al, 2012;Segonzac et al, 2012).…”

Section: Conclusion and Unsolved Problemsmentioning

confidence: 99%

CLAVATA-WUSCHEL signaling in the shoot meristem

2016

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Shoot meristems are maintained by pluripotent stem cells that are controlled by CLAVATA-WUSCHEL feedback signaling. This pathway, which coordinates stem cell proliferation with differentiation, was first identified in Arabidopsis, but appears to be conserved in diverse higher plant species. In this Review, we highlight the commonalities and differences between CLAVATA-WUSCHEL pathways in different species, with an emphasis on Arabidopsis, maize, rice and tomato. We focus on stem cell control in shoot meristems, but also briefly discuss the role of these signaling components in root meristems.

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“…Binding affinity of the arabinosylated 13-aa CLV3p to its receptor CLV1 (K d = 1 nM) is about 100-fold higher than the 13-aa CLV3p without glycosylation (K d = 280 nM) and 10-fold higher than the 12-aa CLV3p (K d = 24 nM) (Ohyama et al 2009). Notably, the 12-aa CLV3p has been recently reported to provide the immune protection in the SAM through the FLS2 receptor (Lee et al 2011) and the 12-aa and the 13-aa CLV3 peptides showed different activities in immune responses (Lee et al 2012b). Recent studies of molecular modeling for the arabinosylated 13-aa CLV3p displayed that arabinosylation causes the conformational distortion of the peptide, and gradually added arabinose residues from one to three proportionally increased biological activities of peptides (Shinohara and Matsubayashi 2012).…”

Section: Introductionmentioning

confidence: 99%

Molecular signaling networks in the shoot apical meristem

Lee

2014

J. Plant Biol.

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Developmental growth and organ formation of all aerial parts of mature plants are thoroughly generated from stem cells in the shoot apical meristem (SAM). More interestingly, the SAM development is mainly established by multiple receptor-mediated signaling pathways induced by stem-cell-triggered peptides. For past few decades, various genetic and biochemical approaches have been employed to investigate the regulation of stem-cell functions through isolating peptide ligands, receptor complexes and early transcription factors that regulate stem-cell homeostasis. However, because signaling molecules have highly redundant properties, the receptor-mediated signaling cascade still remains unclear. Therefore, to better understand important aspects of intracellular signaling networks, this review is mainly focused on recently achieved findings involved in the molecular mechanisms of the SAM.

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Complexity in Differential Peptide–Receptor Signaling: Response to Segonzac et al. and Mueller et al. Commentaries

Cited by 14 publications

References 32 publications

Small Signaling Peptides in Arabidopsis Development: How Cells Communicate Over a Short Distance

Small Signaling Peptides in Arabidopsis Development: How Cells Communicate Over a Short Distance

CLAVATA-WUSCHEL signaling in the shoot meristem

Molecular signaling networks in the shoot apical meristem

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