“…Complexity science has several key concepts that distinguish it from the mechanistic approach: adaptation, lack of hierarchies, self-organization, and emergence. 10,11 Adaptation allows the system to modify its structures (ie, self-organization) and cope with forces or influences from the environment. Since these systems are not passive and adapt by a process of reorganization, they are known as complex adaptive systems (CASs) and defined as "a collection of individual agents with freedom to act in ways that are not always totally predictable, and whose actions are interconnected so that one agent's action changes the context for other agents."…”