Recently, unmanned aerial vehicles (UAVs) have witnessed immense popularity in various fields, ranging from surveillance, rescue, and fire fighting to other more sophisticated military and commercial applications. However, due to their highly nonlinear nature and dynamic operational environment, the control of UAVs is still a challenging task. Linear Quadratic-Gaussian Regulator (LQG), is an optimal control technique, which has been very popular for UAVs control. However, for robust performance, an accurate dynamic model of a system is required. In order, to overcome this limitation, the present work couples an integral sliding mode controller with the LQG controller to deal with the modelling inaccuracies. Experimental results of pitch control of the laboratory-based twin rotor MIMO system (TRMS), validate the performance of ISMC-LQG controller.