Compliance mismatch may promote graft–artery intimal hyperplasia by altering suture-line stresses

Ballyk, Peter D.; Walsh, Colin; Butany, Jagadish; Ojha, Matadial

doi:10.1016/s0197-3975(97)00111-5

Cited by 240 publications

(185 citation statements)

References 34 publications

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“…Because they are designed for different implantation environments, grafts in the 3-6 mm diameter range and those of *1 mm diameter require different design criteria. Most prominently, compliance matching between the arterial wall and graft is absolutely crucial in ensuring long-term patency in the larger grafts made for coronary bypass, 8 but is less relevant at the microsurgical scale, where collaterals will promptly develop and only short-term patency is absolutely required. [9][10][11] The requirement for anastomotic strength and burst pressure will likely differ for the two diameter scales as well.…”

Section: Introductionmentioning

confidence: 99%

Generation, Endothelialization, and Microsurgical Suture Anastomosis of Strong 1-mm-Diameter Collagen Tubes

Nicolescu

et al. 2017

Tissue Engineering Part A

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Tissue-engineered vascular grafts that are based on reconstituted extracellular matrices have been plagued by weak mechanical strength that prevents handling or anastomosis to native vessels. In this study, we devise a method for making dense, suturable collagen tubular constructs of diameter £1 mm for potential microsurgical applications, by dehydrating tubes of native rat tail type I collagen and crosslinking them with 20 mM genipin. Crosslinked dense collagen tubes with 1 mm inner diameter yielded ultimate tensile strength of 342 -15 gF and burst pressure of 1313 -156 mm Hg, comparable to the strength of a rat femoral artery, and supported endothelial cell adhesion and growth. End-to-end anastomosis of 0.5-mm-diameter tubes to explanted arteries displayed anastomotic strength of 82 -21 gF, which is sufficient for surgical applications. In vivo implantation of cell-free tubes as interpositional grafts in the rat femoral circulation yielded stable anastomosis with blood flow for 20 min. Seeded dense collagen tubes represent a promising alternative to venous graft that can potentially be used to bridge between short artery stubs in replantation surgeries.

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Section: Introductionmentioning

confidence: 99%

Generation, Endothelialization, and Microsurgical Suture Anastomosis of Strong 1-mm-Diameter Collagen Tubes

Nicolescu

et al. 2017

Tissue Engineering Part A

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“…[2][3][4] This problem appears to be due to the lack of endothelial cells, thrombus formation by foreign bodies, and intimal hyperplasia at the graft-vein anastomotic site due to compliance mismatch with the native vessels. 3,[5][6][7][8] Silk fibroin (SF) is a natural polymer that is biocompatible, biodegradable and has various processing abilities, which makes it an ideal material for small diameter artificial vascular grafts. [9][10][11][12][13] Silk fibers are primarily composed of 2 types of proteins, sericin and SF.…”

Section: Introductionmentioning

confidence: 99%

Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

et al. 2015

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ABSTRACT. Vascular grafts under 5 mm or less in diameter are not developed due to a problem caused by early thrombus formation, neointimal hyperplasia, etc. Bombyx mori silk fibroin (SF) which has biodegradability and tissue infiltration is focused as tube and coating material of vascular grafts. Coating is an important factor to maintain the strength of the anastomotic region of vascular grafts, and to prevent the blood leak from the vascular grafts after implantation. Therefore, in this research, we focused on the SF concentration of the coating solution, and tissue infiltration and remodeling were compared among each SF concentration. Silk poly (-ethylene) glycol diglycidyl ether (PGDE) coating with concentrations of 1.0%, 2.5%, 5.0%, and 7.5% SF were applied for the double-raschel knitted small-sized vessel with 1.5 mm diameter and 1cm in length. The grafts were implanted in the rat abdominal aorta and removed after 3 weeks or 3 months. Vascular grafts patency was monitored by ultrasound, and morphological evaluation was performed by histopathological examination. SF concentration had no significant effects on the patency rate. However, tissue infiltration was significantly higher in the sample of 2.5% SF in 3 weeks, and 1.0% and 2.5% SF in 3 months. Also, in comparison of length inside of the graft, stenosis were not found in 3 weeks, however, found with 5.0% and 7.5% in 3 months. From these results, it is clear that 2.5% SF coating is the most suitable concentration, based on the characteristics of less stenosis, early tissue infiltration, and less neointimal hyperplasia.

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“…28 This will lead to the formation of intimal hyperplasia (IH). [29][30][31] Thrombosis and IH are different processes; however few studies reported the existence of a relationship between thrombosis and the occurrence of IH, particularly after bypass surgery or angioplasty. 32,33 Thrombin is one of the vital proteins involved in the coagulation pathway: it converts fibrinogen …”

Section: Cardiovascular Graftsmentioning

confidence: 99%

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Vellayappan¹,

Balaji²,

Subramanian³

et al. 2015

IJN

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Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease.

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Compliance mismatch may promote graft–artery intimal hyperplasia by altering suture-line stresses

Cited by 240 publications

References 34 publications

Generation, Endothelialization, and Microsurgical Suture Anastomosis of Strong 1-mm-Diameter Collagen Tubes

Generation, Endothelialization, and Microsurgical Suture Anastomosis of Strong 1-mm-Diameter Collagen Tubes

Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

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