Compliance of asthmatic families with a primary prevention programme of asthma and effectiveness of measures to reduce inhalant allergens – a randomized trial

Schönberger, H. J. A. M.; Maas, Tanja; Dompeling, Edward; Knottnerus, J. A.; Weel, Chris van; Schayck, C.P. van

doi:10.1111/j.1365-2222.2004.01991.x

Cited by 33 publications

(16 citation statements)

References 32 publications

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“…Measurement of environmental exposure to HDM, cat and dog allergens was performed during pregnancy (baseline) and exactly 1 yr later. One year after baseline measurements the concentration of HDM, cat and dog allergens, measured at the living room floor (except for dog allergens), the mattress of the parents and the mattress of the baby, were statistically significant decreased in the intervention group, but not in the control group (29).…”

Section: Preliminary Results Of the Rcptmentioning

confidence: 97%

The primary prevention of asthma in children study: Design of a multifaceted prevention program

Kuiper

Maas

Schayck

et al. 2005

Pediatric Allergy Immunology

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The PREVASC study addresses the primary prevention of asthma in infants and small children. The objective of this study is to investigate whether a multifaceted prenatally started intervention strategy in high-risk infants leads to a decrease in the occurrence of (severe) asthma and whether a refinement of the prevention strategy leads to an increase in the adherence to the prevention program. The primary prevention program includes house dust mite impermeable bed coverings, education on breast feeding, hypoallergenic feeding, timing of introduction of solid food and smoking cessation. A total of 888 infants were prenatally included. By the time of inclusion the mothers were 3-7 months pregnant. About 27 infants were excluded from the study and 18 dropped out. Of the remaining 843 infants 535 had a first-degree familial predisposition of asthma (high-risk group), whereas a reference group of 308 (162 boys) infants was not predisposed for asthma in the first-degree (low-risk group). To evaluate the (cost-)effectiveness of the preventive intervention, 222 (118 boys) infants of the high-risk group allocated to the intervention group and 221 (112 boys) allocated to a control group are followed up. The low-risk infants served as controls to evaluate the predictive value of high risk (first-degree familial predisposition of asthma). The infants are followed from the prenatal stage until they reach the age of 6 yr. The remaining 92 high-risk infants were included in an optimized randomized-clinical adherence trial (RCAT). Of these 92 infants, 45 (20 boys) were allocated to an intervention group and 47 (24 boys) to a control group. Until now all infants have been followed for at least 1 yr.

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Section: Preliminary Results Of the Rcptmentioning

confidence: 97%

The primary prevention of asthma in children study: Design of a multifaceted prevention program

Kuiper

Maas

Schayck

et al. 2005

Pediatric Allergy Immunology

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“…Trials ultimately selected for review can be divided into those utilizing a monofaceted, dust avoidance, approach: Prevention and Incidence of Asthma and Mite Allergy (PIAMA) (12,(17)(18)(19)(20)(21)(22), Childhood Asthma Prevention Study (CAPS) (14,(23)(24)(25)(26)(27), and the National Asthma Campaign Manchester Asthma and Allergy Study ( NAC MASS) (15,(28)(29)(30)(31), and those using a multifaceted allergen avoidance approach: Isle of Wight prevention study (10,(32)(33)(34)(35)(36)(37), Canadian Asthma Primary Prevention Study (CAPPS) (11,(38)(39)(40)(41), Study of Prevention of Allergy in Children of Europe (SPACE) (13,42,43), and the Prevention of Asthma in Children (PREVASC) (16,(44)(45)(46)(47). Studies using a monofaceted dust avoidance approach were combined in a meta-analysis, while studies using a multifaceted approach were deemed too heterogeneous to be combined.…”

Section: Resultsmentioning

confidence: 99%

Dust mite avoidance for the primary prevention of atopic dermatitis: A systematic review and meta‐analysis

Bremmer

Simpson

2015

Pediatric Allergy Immunology

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Dust mite avoidance strategies alone or in combination with additional allergen avoidance modalities do not decrease the risk of developing atopic dermatitis and, given the current state of the evidence, should not be recommended for this purpose. The utility of dust mite avoidance for the treatment of atopic dermatitis or for the prevention and treatment of asthma or seasonal rhinoconjunctivitis are outside the scope of this review.

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“…This led to reduced exposure to mite, cat, and dog allergens on the mattresses and in the living room. 127 …”

Section: Executive Summary: Furry Animalsmentioning

confidence: 99%

Environmental assessment and exposure control: a practice parameter—furry animals

Portnoy¹,

Kennedy²,

Sublett³

et al. 2012

Annals of Allergy, Asthma & Immunology

106

128

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Compliance of asthmatic families with a primary prevention programme of asthma and effectiveness of measures to reduce inhalant allergens – a randomized trial

Cited by 33 publications

References 32 publications

The primary prevention of asthma in children study: Design of a multifaceted prevention program

The primary prevention of asthma in children study: Design of a multifaceted prevention program

Dust mite avoidance for the primary prevention of atopic dermatitis: A systematic review and meta‐analysis

Environmental assessment and exposure control: a practice parameter—furry animals

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