Compliance properties of a composite electrospun fibre – hydrogel blood vessel scaffold

Liu, Y.; Zahedmanesh, Houman; Lally, Caitríona; Cahill, Paul A.; McGuinness, Garrett B.

doi:10.1016/j.matlet.2016.05.050

Cited by 14 publications

(7 citation statements)

References 13 publications

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“…However, traditional hydrogels are exceedingly fragile because of their intrinsic inhomogeneous structure and lack of any energy dissipation mechanism [ 13 , 14 ]. These shortcomings severely limit the practical application of hydrogels in artificial muscles [ 15 ], cartilages [ 16 ], blood vessels [ 17 ], and tendons [ 18 ], which require toughness and load-bearing areas; therefore, it is necessary to design hydrogels with remarkable mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Tuning Physical Crosslinks in Hybrid Hydrogels for Network Structure Analysis and Mechanical Reinforcement

Liu

Shao

2019

Polymers

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Hydrogels with high mechanical strength are needed for a variety of industrial applications. Here, a series of hydrogels was prepared by introducing hybrid particles as hydrophobic association points to toughen the hydrogels. These toughened hydrogels were able to transfer an external mechanical force via the reorganization of the crosslinking networks. They exhibited an extraordinary mechanical performance, which was the result of the coordination between hydrophobic segments and hybrid particles. Herein, the connection between the dissipated energy of the inner distribution structure (on a small scale) and the mechanical properties (on a large scale) was conducted. Specifically, we inspected hydrogels of latex particles (LPs) with different chain lengths (C4, C12, C18) and studied their inner structural parameters, namely, the relationship between the density and molecular weight of crosslinking points to the mechanical strength and energy dissipation. Favorable traits of the hydrogels included compact internal structures that were basically free from defects and external structures with puncture resistance, high toughness, etc. Based on the experimental results that agreed with the theoretical results, this study provides a profound understanding of the internal structure of hydrogels, and it offers a new idea for the design of high-strength hybrid hydrogels.

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Section: Introductionmentioning

confidence: 99%

Tuning Physical Crosslinks in Hybrid Hydrogels for Network Structure Analysis and Mechanical Reinforcement

Liu

Shao

2019

Polymers

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“…Although a well‐established material engineering technique, dip‐coating has yet to be studied thoroughly as an approach to generate vascular conduit tubes. In many reports within the scientific literature, electrospinning has been presented as the technique of choice in the fabrication of vascular graft conduits 30,40,63–65. Electrospun conduits are most commonly formed by electrospinning layers of polymer fibers onto a rotating cylindrical mandrel 40,63–67.…”

Section: Discussionmentioning

confidence: 99%

“…In many reports within the scientific literature, electrospinning has been presented as the technique of choice in the fabrication of vascular graft conduits 30,40,63–65. Electrospun conduits are most commonly formed by electrospinning layers of polymer fibers onto a rotating cylindrical mandrel 40,63–67. This approach is not without its challenges; there are anecdotal reports about the difficulties in removing the fibrous tube from the mandrel without damaging the integrity of the conduit 64.…”

Section: Discussionmentioning

confidence: 99%

Matching Static and Dynamic Compliance of Small‐Diameter Arteries, with Poly(lactide‐co‐caprolactone) Copolymers: In Vitro and In Vivo Studies

Behr

Irvine

Thwin

et al. 2020

Macromolecular Bioscience

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Mechanical mismatch between vascular grafts and blood vessels is a major cause of smaller diameter vascular graft failure. To minimize this mismatch, several poly‐l‐lactide‐co‐ε‐caprolactone (PLC) copolymers are evaluated as candidate materials to fabricate a small diameter graft. Using these materials, tubular prostheses of 4 mm inner diameter are fabricated by dip‐coating. In vitro static and dynamic compliance tests are conducted, using custom‐built apparatus featuring a closed flow system with water at 37 °C. Grafts of PLC monomer ratio of 50:50 are the most compliant (1.56% ± 0.31∙mm Hg−2), close to that of porcine aortic branch arteries (1.56% ± 0.43∙mm Hg−2), but underwent high continuous dilatation (87 µm min−1). Better matching is achieved by optimizing the thickness of a tubular conduit made from 70:30 PLC grafts. In vivo implantation and function of a PLC 70:30 conduit of 150 µm wall‐thickness (WT) are tested as a rabbit aorta bypass. An implanted 150 µm WT PLC 70:30 prosthesis is observed over 3 h. The recorded angiogram shows continuous blood flow, no aneurysmal dilatation, leaks, or acute thrombosis during the in vivo test, indicating the potential for clinical applications.

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“…10,11 In the vascularization of skull scaffolds, the three-dimensional (3D) vascular network has better nutrient exchange and cell perfusion capabilities. 3,9,10 Recent research on engineered multi-scale microchannels such as vessel-on-chip models, 5,12 3D blood vessels, 10,13 and prefabricated scaffolds with vascular structures 10,[13][14][15][16][17][18][19] shows promise, but there are still challenges in the precise direct fabrication of hollow hierarchical vascular networks with biocompatible hydrogels. Direct manufacturing of complex spatial structures 12,20 is more efficient and accurate than indirect manufacturing, 10,[13][14][15][16][17][18][19] which helps to simulate the real cell growth microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Adjusting the accuracy of PEGDA-GelMA vascular network by dark pigments via digital light processing printing

Sheng

Zheng

et al. 2021

J Biomater Appl

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Vascularization is one of the most important factors greatly influencing scaffold regeneration. In this study, a precise network of hollow vessels was printed by digital light processing (DLP) with poly(ethylene glycol) diacrylate (PEGDA)/gelatin-methacryloyl (GelMA), and dark pigmentation absorbers were added to ensure printing accuracy. First, the compound bio-inks of the PEGDA-GelMA hydrogel were prepared for direct vascular printing, and a high-precision DLP system was established. Second, the printing effects of three dark absorbers, namely, nigrosin, brilliant black, and brilliant blue, on the x-, y-, and z-axes were studied. By printing models with different densities, it was determined that 0.2% nigrosin, 0.1% brilliant black, and 0.3% brilliant blue had better effects on the x- and y-axes accuracy, and the absorbance of the absorbers played a decisive role in adjusting the accuracy. Additionally, to solve the problem of uneven curing on the upper and lower surfaces caused by the addition of an absorber with high absorbance, a model of the difference in curing width between the upper and lower surfaces of a unit-layer slice based on high-absorbance absorbers was established, and the reference value for the slice thickness was calculated. Third, the biological and mechanical properties of the bio-inks were verified with scanning electron microscopy and Fourier transform infrared, and by tensile, swelling, degradation, and cytotoxicity tests on different concentrations of PEGDA-GelMA hydrogel and absorbers. The results showed that 30% PEGDA-7% GelMA/0.1% brilliant black was the optimal preparation to print a hollow vascular network. The error of the printing tube wall and cavity was between 1% and 3%, which demonstrates the high precision of the method. Human umbilical vein endothelial cells were planted in the lumen, and the survival rate achieved 107% on the seventh day, demonstrating the good biocompatibility of the composite hydrogel.

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Compliance properties of a composite electrospun fibre – hydrogel blood vessel scaffold

Cited by 14 publications

References 13 publications

Tuning Physical Crosslinks in Hybrid Hydrogels for Network Structure Analysis and Mechanical Reinforcement

Tuning Physical Crosslinks in Hybrid Hydrogels for Network Structure Analysis and Mechanical Reinforcement

Matching Static and Dynamic Compliance of Small‐Diameter Arteries, with Poly(lactide‐co‐caprolactone) Copolymers: In Vitro and In Vivo Studies

Adjusting the accuracy of PEGDA-GelMA vascular network by dark pigments via digital light processing printing

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