Complicaciones del túnel y orificio de salida del catéter peritoneal

Pesquera, José Ignacio Minguela; Gauna, Ramón Ruiz de; González, Rosa Inés Muñoz

doi:10.1016/b978-84-8086-394-0.50014-9

Tratado De Diálisis Peritoneal 2009

DOI: 10.1016/b978-84-8086-394-0.50014-9

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Complicaciones del túnel y orificio de salida del catéter peritoneal

José Ignacio Minguela Pesquera¹,

Ramón Ruiz de Gauna²,

Rosa Inés Muñoz González³

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2014

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“…The common use of other antibiotics such as topical ciprofloxacin, which reduces exit-site infections caused by S. aureus and P. aeruginosa , as well as the topical use of gentamicin, seem to lead to good results, although some authors refer possible manifestations of resistances and infections caused by uncommon organisms, such as Corynebacterium spp (10), Mycobacteria , or fungus (11).…”

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Exit-Site Infection of Peritoneal Catheter is Reduced by the Use of Polyhexanide. Results of a Prospective Randomized Trial

et al. 2014

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♦ Background: One of the most common and severe complications affecting peritoneal dialysis (PD) patients is exit-site infection of the peritoneal catheter; it is therefore of vital importance to prevent it. This complication has a negative impact on the success of the technique. In spite of this, there are no clear guidelines concerning how to take care of the exit site. The objective of this study was to assess the efficacy of polyhexanide in preventing exit-site infection over a 12-month period. ♦ Methods: We designed a single-center, prospective, open-labeled, randomized controlled clinical trial with parallel groups. Requirements for participation in the study included implantation of the peritoneal catheter at least six weeks before entering the study and no infectious complications requiring either hospital admission or antibiotic treatment for at least three months before entering into the study. Patients were randomized to be daily cured as follows: Group A: traditional care with saline serum and povidone-iodine; and Group B: polyhexanide solution. Exit sites were evaluated at baseline and every four to six weeks or if any event occurred, according to the Twardowski criteria. ♦ Results: Of the 60 included patients, 46 completed the 12-month follow-up period. Six underwent transplantation, five died and three were transferred to hemodialysis (HD). The treatment was well tolerated, with no side effects nor abandonments due to such effects. Throughout the study period, six patients (20%) undergoing traditional care and only two (6,7%) receiving polyhexanide developed an exit-site infection (p = 0.032). There were a total number of 12 infections; nine occurred in patients following the traditional approach and only three in patients treated with polyhexanide (p = 0.037). The germs responsible for the infections were: S. aureus (six cases), Corynebacterium jeikeium (two cases) and P. aeruginosa (one case) in the saline serum and povidone-iodine group and P. aeruginosa (three cases) in the polyhexanide group. The mean rate of exit-site infection was 1 episode/36.6 patient-months for the traditional care group and 1 episode/102.7 patient-months for the polyhexanide group (p = 0.017). Patients following the traditional treatment required fewer days to get infected than those using polyhexanide (p = 0.033; log rank: 4.2). ♦ Conclusions: These results show that using polyhexanide is efficient for the prevention of exit-site infections. Patients treated with this product suffer from fewer infections and need more time to become infected. Polyhexanide application is painless, no allergies have been described and it is well tolerated by patients. We therefore propose that it may be used routinely from now on for the care of healthy exit site.

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“…The aim of the present study is to assess the efficacy of polyhexanide compared to the standard cure used (0.9% saline serum and povidone-iodine (2,11,17)) in preventing exit-site infections.…”

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confidence: 99%

Exit-Site Infection of Peritoneal Catheter is Reduced by the Use of Polyhexanide. Results of a Prospective Randomized Trial

et al. 2014

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Complicaciones del túnel y orificio de salida del catéter peritoneal

Cited by 1 publication

References 54 publications

Exit-Site Infection of Peritoneal Catheter is Reduced by the Use of Polyhexanide. Results of a Prospective Randomized Trial

Exit-Site Infection of Peritoneal Catheter is Reduced by the Use of Polyhexanide. Results of a Prospective Randomized Trial

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