Complication of improper management of sodium hypochlorite accident during root canal treatment

Faras, Fatemah; Abo-Alhassan, Fawaz; Sadeq, Abdullah; Burezq, Hisham

doi:10.4103/2231-0762.192939

Cited by 33 publications

(31 citation statements)

References 8 publications

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“…Chlorhexidine and sodium hypochlorite proved to be active against common bacterial and fungal pathogens at lower concentrations compared to HybenX ® . Nonetheless, it has to be noted that Hybenx ® is actually administered undiluted, while chlorhexidine is usually applied in solutions ranging from 0.02% to 2% [7][8][9], and sodium hypochlorite 0.02-5.25% [10][11][12]. The activity of HybenX ® against S. aureus and E. faecalis appears to be of particular relevance due to the role of these pathogens in some periodontal infections (e.g., chronic and aggressive periodontitis) [13,14].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

et al. 2019

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The recent increase in infections mediated by drug-resistant bacterial and fungal pathogens underlines the urgent need for novel antimicrobial compounds. In this study, the antimicrobial activity (inhibitory and cidal) of HybenX ® , a novel dessicating agent, in comparison with commonly used sodium hypochlorite and chlorhexidine, against a collection of bacterial and yeast strains representative of the most common human pathogenic species was evaluated. The minimal inhibitory, bactericidal, and fungicidal concentrations (MIC, MBC, and MFC, respectively) of the three different antimicrobial agents were evaluated by broth microdilution assays, followed by subculturing of suitable dilutions. HybenX ® was active against 26 reference strains representative of staphylococci, enterococci, Enterobacterales, Gram-negative nonfermenters, and yeasts, although at higher concentrations than sodium hypochlorite and chlorhexidine. HybenX ® MICs were 0.39% for bacteria (with MBCs ranging between 0.39% and 0.78%), and 0.1-0.78% for yeasts (with MFCs ranging between 0.78% and 1.6%). HybenX ® exhibited potent inhibitory and cidal activity at low concentrations against several bacterial and yeast pathogens. These findings suggest that HybenX ® could be of interest for the treatment of parodontal and endodontic infections and also for bacterial and fungal infections of other mucous membranes and skin as an alternative to sodium hypochlorite and chlorhexidine.

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Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

et al. 2019

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“…The crystal violet coloration used in the OD value test not only showed color changes occurring in the cell but also the secang solutions color attached to the surface of the plate; therefore, it may have overestimated the number of microorganism cells attached [7,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…2.5% NaOCl can be recommended, as it has the same effectiveness as 5.25% NaOCl but is less toxic [6]. There has been a report of NaOCl extrusion into periapical tissues including acute pain, swelling, hemorrhage, numbness, and secondary infection [7].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Efficacy of Secang Heartwood (Caesalpinia Sappan L.) Solutions on Biofilms of Candida Albicans Atcc 10231

et al. 2019

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Objective: Candida albicans is a predominant fungal species found in persistent root canal infection, and its virulence depends on the ability to formbiofilms. To be able to eliminate this infection, a safe irrigation solution during root canal preparation is needed. This study is conducted to investigatethe antifungal properties of secang heartwood extract solutions on C. albicans biofilm.Methods: C. albicans biofilm was obtained from incubation of C. albicans ATCC 10231 at 96-well plates in 37°C for 24 h. These biofilms were exposedto various treatments: Secang heartwood in three different concentrations (25%, 33%, and 50%), sodium hypochlorite (NaOCl) 2.5%, and controlgroup. The results of the treatment are to see the optical density (OD) value. The higher the OD values, the lower antifungal activity of the solution.Results: The mean OD result from six samples obtained the mean value of various OD values showed in ELISA reader. Antifungal efficacy of 25%secang heartwood was lower than concentration of 33% and 50%. All concentrations of secang heartwood showed higher OD values than 2.5% NaOClbut lower than control group with p=0.01.Conclusion: Secang heartwood possesses antifungal effects against C. albicans biofilm but is lower than 2.5% NaOCl. Concentration of 25% has thestrongest effect against C. albicans among other concentrations. This was a preliminary study of the antifungal efficacy of secang heartwood extractsolutions against C. albicans biofilm. The result indicates that this solution has the potential to be used as an herbal alternative in root canal irrigations.

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“…To avoid such negligence, it is always better to do color coding for syringes and when in doubt, throw the syringe and use fresh needle, syringe, and anesthetic solution. [ 37 38 39 40 41 ]…”

Section: Ertain a Cts Are C mentioning

confidence: 99%

A review of medicolegal considerations of endodontic practice for general dental practitioners

Ramugade¹,

Sagale²

2018

J Int Soc Prevent Communit Dent

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Treating a live human being to their health has been considered as a noble profession since the ancient times. Doctors are duty bound by their professional ethics to provide the best treatment to their patients. Endodontics is the specialty branch of the dental science of saving natural teeth in the oral cavity. During endodontic procedures, a mishap can occur any time in a day-to-day practice and may be treated as negligence which in turn ends into some legal complications. To prevent and tackle such future medicolegal issues related to endodontic treatment, the knowledge of the legal aspect of such clinical situation is necessary.

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Complication of improper management of sodium hypochlorite accident during root canal treatment

Cited by 33 publications

References 8 publications

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

Antifungal Efficacy of Secang Heartwood (Caesalpinia Sappan L.) Solutions on Biofilms of Candida Albicans Atcc 10231

A review of medicolegal considerations of endodontic practice for general dental practitioners

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