Complication of post-infectious bronchiolitis obliterans (Swyer-James syndrome)

Vieira, Gabriel de Deus; Yamagishi, Alessandra Yukari; Vieira, Natália Nogueira; Fogaça, Rebeka Mayara Miranda Dias; Alves, Thaianne da Cunha; Amaral, Gisele Megale Brandão Gurgel; Sousa, Carlos Antônio Ferreira de

doi:10.1590/1806-9282.61.05.404

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…Obliteration of the pulmonary capillary network decreases the flow of blood into the pulmonary artery segments and triggers arterial hypoplasia. 28,29…”

Section: Pulmonary Function Tests (Pft)mentioning

confidence: 99%

Postinfectious Bronchiolitis Obliterans

Yılmaz

Pekcan

2021

J. Pediatr. Acad.

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Childhood bronchiolitis obliterans (BO) is an uncommon complication that is characterized clinically by persistent and continuous obstructive respiratory symptoms, and has been described secondary to various etiologic factors, including drugs, exposure to toxic fumes, allergic reactions, collagen vascular disease or infections. BO occurs most commonly in children after an episode of acute bronchiolitis and is considered a long-term sequela of viral infection.Postinfectious Bronchiolitis Obliterans (PIBO) is characterized by persistent airway obstruction with functional and radiological evidence of small airway involvement that is in general unresponsive to bronchodilator treatment.Although the condition is relatively rare, and its exact incidence is unknown, it is important to keep it in mind. PIBO is complication of lower respiratory tract epithelial injury, and is often misdiagnosed, delaying recognition and potential treatment. A PIBO diagnosis is usually based on a few factors, including a good medical history, positive clinical findings, and lung function test and imaging results, although biopsy and histopathology remain as the optimum diagnostic approach. There have to date been few studies proposing treatments for the condition, and no accepted protocol exists in literature. There is usually a fixed airway obstruction in PIBO. Various treatment approaches have been extrapolated from studies of post bone marrow transplantations and lung transplant BO. The clinical course is variable, and good supportive therapy is essential, with anti-inflammatory therapy often being employed.

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“…Obliteration of the pulmonary capillary network decreases the flow of blood into the pulmonary artery segments and triggers arterial hypoplasia. 28,29…”

Section: Pulmonary Function Tests (Pft)mentioning

confidence: 99%

Postinfectious Bronchiolitis Obliterans

Yılmaz

Pekcan

2021

J. Pediatr. Acad.

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“…Inflammation and fibrosis of terminal bronchioles causes narrowing and/or complete obliteration of the airway lumen, leading to chronic airflow obstruction. 1 , 2 , 3 , 4 , 5 , 6 , 7 These anatomofunctional changes can result in progressive loss of strength/endurance of ventilatory muscles, directly contributing to the reduction in activities of daily living (ADLs), with a consequent negative impact on exercise tolerance. 8 …”

Section: Introductionmentioning

confidence: 99%

Exercise Capacity in Children and Adolescents With Post-Infectious Bronchiolitis Obliterans: A Systematic Review

Rodrigues

Schiwe

Campos

et al. 2019

Rev. paul. pediatr.

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Objective: To evaluate exercise capacity in children and adolescents with post-infectious bronchiolitis obliterans. Data source: This is a systematic review based on data from PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), and Physiotherapy Evidence Database (PEDro). We used the following search strategy: “Exercise capacity OR Exercise Test OR Physical fitness OR Functional capacity OR Six-minute walk test OR Shuttle walk test OR Cardiopulmonary exercise test AND Bronchiolitis obliterans.” We selected studies that evaluated exercise capacity through maximal/submaximal testing in children and adolescents with post-infectious bronchiolitis obliterans, and no other associated disease. We searched articles in English, Portuguese, and Spanish, without restrictions regarding the period of publication. The methodological quality was assessed by the Agency for Healthcare Research and Quality (AHRQ) protocol. Data synthesis: Out of the 81 articles found, only 4 were included in this review. The studies totaled 135 participants (121 with post-infectious bronchiolitis obliterans and 14 healthy), with sample sizes between 14 and 58 subjects. All patients underwent spirometry to evaluate pulmonary function, indicating an obstructive ventilatory pattern. Among them, 3/4 had their physical performance assessed by the six-minute walk test and 2/4 by the cardiopulmonary exercise testing. These test results were compared to those of a control group (1/4) and presented as percentage of predicted and/or in meters (3/4). Lastly, 3/4 of the studies showed reduced exercise capacity in this population. The studies included were classified as having high methodological quality. Conclusions: Findings of the study demonstrate that children and adolescents with post-infectious bronchiolitis obliterans have reduced exercise capacity.

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Swyer-James-Macleod Syndrome in a Geriatric Patient: a Case Report

Panchal,

Shah,

Bhowmik

et al. 2023

SN Compr. Clin. Med.

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Hyper-lucent lung syndrome or Swyer-James-Macleod syndrome is a rare, often an incidental nding, primarily showing unilateral hyper-lucency as a consequence of bronchiolitis obliterans. Often diagnosed in early childhood; though in some cases it may only be discovered in adulthood or on account of recurrent chest infections. Case Presentation:A patient presented to our outpatient center with complaints of shortness of breath with mild to moderate exertional dyspnea & exacerbations of symptoms classically associated with chronic obstructive pulmonary disease. Complaints have persisted for several years with waxing & waning intensity. There is a history of migraine, atrial brillation, hypothyroidism, and colon & breast cancer without recurrence.Computed tomography of the chest with intravenous contrast showed asymmetric emphysematous changes with marked hyperin ation & attenuated vasculatures con ned to the middle lobe of the right lung.The patient was started on a combination of inhaled long-acting beta-agonists, corticosteroids & longacting muscarinic antagonists and is almost asymptomatic. Conclusion:Geriatric patients are at increased risk of various age-related diseases, respiratory disorders being among them. Knowledge of this rare condition allows for its appropriate management as it often coexists with bronchiectasis & results in frequent respiratory infections, which may be preventable.

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Complication of post-infectious bronchiolitis obliterans (Swyer-James syndrome)

Cited by 6 publications

References 10 publications

Postinfectious Bronchiolitis Obliterans

Postinfectious Bronchiolitis Obliterans

Exercise Capacity in Children and Adolescents With Post-Infectious Bronchiolitis Obliterans: A Systematic Review

Swyer-James-Macleod Syndrome in a Geriatric Patient: a Case Report

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