Complications after breast augmentation with dermal fillers containing copolyamide: A systematic review

Hedström, Karin; Falk-Delgado, Alberto; Sackey, Helena

doi:10.1016/j.jpra.2024.01.009

JPRAS Open

2024

DOI: 10.1016/j.jpra.2024.01.009

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Complications after breast augmentation with dermal fillers containing copolyamide: A systematic review

Karin Hedström,

Alberto Falk-Delgado,

Helena Sackey

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2024

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Cited by 4 publications

References 22 publications

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The first experience of using a biodegradable collagen matrix for the prevention of contour deformation of the breast after sectoral resection for a benign formation

Naidina,

Zikiryakhodzhaev,

Davydov

et al. 2024

Plas. Surg. Aest. Med.

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The first experience of using a biodegradable collagen matrix for the prevention of contour deformation of the breast after sectoral resection for a benign formation

Naidina,

Zikiryakhodzhaev,

Davydov

et al. 2024

Plas. Surg. Aest. Med.

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Long-Term Complications of Aquafilling Injection after Male Breast Augmentation: A Case Report

Fast,

Radtke

2024

Life

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(1) Background: Aquafilling, a filler initially designed for contouring the face, was developed in 2005 by the company Biomedica, Czech Republic. It is composed of 98% hydrophilic gel and 2% copolyamide. Since 2008 the use was expanded for augmentation of the breast and gluteal region. It is suitable as a nonsurgical method for patients who want discreet augmentation and would like to avoid undergoing an operation. This method promises long-term results lasting up to 10 years. However, according to the literature Aquafilling gel can cause long-term complications; (2) Methods: This case report presents a male patient who experienced severe complications following Aquafilling injections for breast augmentation after ten years of treatment; (3) Results: A 51-year-old male patient presented to our emergency room with complaints of pain, firmness, major pre-pectoral swelling and asymmetry in his breasts. Due to the severity of the clinical appearance and the patient’s discomfort, surgical intervention was deemed necessary. After undergoing three operations the patient was treated successfully and could be discharged for outpatient controls. The patient still did not show any signs of complications, three months after the event; (4) Conclusions: Although the patient has made a rapid recovery, as a result of the surgical procedure, we would recommend treating the breast region with small incisions and drainage in the future. This would have a better aesthetic result. Still there is no antidote available for the treatment of Aquafilling gel. It can only be removed by surgical debridement or irrigation and drainage.

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Long-Term Biodegradation of Polyacrylamide Gel Residues in Mammary Glands: Physico-Chemical Analysis, Chromatographic Detection, and Implications for Chronic Inflammation

Legonkova,

Sultanova,

Stafford

et al. 2024

Molecules

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In the past, polyacrylamide hydrogel was a popular choice for breast augmentation filler, and many women underwent mammoplasty with this gel. However, due to frequent complications, the use of polyacrylamide hydrogel in mammoplasty has been banned. Despite this ban, patients experiencing complications still seek medical treatment. The aim of this study was to investigate the fate of the polymer over a defined implantation period. Biopsies of breast implants were obtained from patients with 23 and 27 years of post-mammoplasty. These biopsies were meticulously purified from biological impurities and subjected to analysis using IR spectrometry, liquid chromatography—mass spectrometry, gas chromatography, and differential scanning calorimetry. The findings revealed the presence of polyacrylamide hydrogel residues, along with degradation products, within the infected material. Notably, the low-molecular-weight degradation products revealed via gas chromatography are aggressive and toxic substances capable of inducing chronic inflammation. This study sheds light on the long-term consequences of polyacrylamide hydrogel implantation, highlighting the persistence of harmful degradation products and their role in exacerbating patient complications.

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Complications after breast augmentation with dermal fillers containing copolyamide: A systematic review

Cited by 4 publications

References 22 publications

The first experience of using a biodegradable collagen matrix for the prevention of contour deformation of the breast after sectoral resection for a benign formation

The first experience of using a biodegradable collagen matrix for the prevention of contour deformation of the breast after sectoral resection for a benign formation

Long-Term Complications of Aquafilling Injection after Male Breast Augmentation: A Case Report

Long-Term Biodegradation of Polyacrylamide Gel Residues in Mammary Glands: Physico-Chemical Analysis, Chromatographic Detection, and Implications for Chronic Inflammation

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