Patellar luxation (PL) is one of the most common orthopedic disorders in dogs and a
genetic factor is considered to play an important role in the development of PL. Genomic
analysis has attempted to identify the genetic markers associated with the development of
PL but only suggestive markers have been identified. Carefully selecting breeds with
higher incidence rates of congenital PL as well as affected dogs with more severe symptoms
are required, but such information remains limited to date. This study aimed to assess the
genetic contribution to the development of PL in puppies. Using data on PL from 2,048
puppies of the nine common breeds in Japan, the association of PL grades between the
limbs, breed, and sex as well as the concordance of PL between littermates were examined.
A significant correlation was found between right and left limbs in PL grades in all the
puppies (Spearman rank correlation coefficient (r
s
)=0.91,
P
<0.001) and for each breed (r
s
=0.81–0.93,
P
<0.001). In total, 20.3% of the puppies were affected. The
inter-breed difference in PL prevalence was 2.1–38.1%, and Toy Poodles showed the highest
prevalence rates. Littermates of the affected puppies with PL grade ≥2 had a 16.2-fold
higher risk (
P
<0.001). Thus, these results suggest that PL in puppies
is primarily influenced by genetics, especially in Toy Poodles. These data highlight the
necessity of using a breeding scheme to decrease the prevalence of PL.